BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

99 related articles for article (PubMed ID: 15516756)

  • 41. Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate.
    Di Fabio R; Alvaro G; Griffante C; Pizzi DA; Donati D; Mattioli M; Cimarosti Z; Guercio G; Marchioro C; Provera S; Zonzini L; Montanari D; Melotto S; Gerrard PA; Trist DG; Ratti E; Corsi M
    J Med Chem; 2011 Feb; 54(4):1071-9. PubMed ID: 21229983
    [TBL] [Abstract][Full Text] [Related]  

  • 42. Novel piperazines: potent melanocortin-4 receptor antagonists with anxiolytic-like activity.
    Nozawa D; Okubo T; Ishii T; Takamori K; Chaki S; Okuyama S; Nakazato A
    Bioorg Med Chem; 2007 Mar; 15(6):2375-85. PubMed ID: 17267226
    [TBL] [Abstract][Full Text] [Related]  

  • 43. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells.
    Johnston PA; Nguyen MM; Dar JA; Ai J; Wang Y; Masoodi KZ; Shun T; Shinde S; Camarco DP; Hua Y; Huryn DM; Wilson GM; Lazo JS; Nelson JB; Wipf P; Wang Z
    Assay Drug Dev Technol; 2016 May; 14(4):226-39. PubMed ID: 27187604
    [TBL] [Abstract][Full Text] [Related]  

  • 44. Synthesis and biological evaluation of (phenylpiperazinyl-propyl)arylsulfonamides as selective 5-HT(2A) receptor antagonists.
    Yoo E; Yoon J; Pae AN; Rhim H; Park WK; Kong JY; Park Choo HY
    Bioorg Med Chem; 2010 Feb; 18(4):1665-75. PubMed ID: 20096593
    [TBL] [Abstract][Full Text] [Related]  

  • 45. Synthesis and characterization of environment-sensitive fluorescent ligands for human 5-HT1A receptors with 1-arylpiperazine structure.
    Lacivita E; Leopoldo M; Masotti AC; Inglese C; Berardi F; Perrone R; Ganguly S; Jafurulla M; Chattopadhyay A
    J Med Chem; 2009 Dec; 52(23):7892-6. PubMed ID: 19705871
    [TBL] [Abstract][Full Text] [Related]  

  • 46. Design, synthesis, crystal structure, biological evaluation and molecular docking studies of carbazole-arylpiperazine derivatives.
    Xu W; Huang J; Shao B; Xu X; Jiang R; Yuan M
    Bioorg Med Chem; 2016 Nov; 24(21):5565-5572. PubMed ID: 27663545
    [TBL] [Abstract][Full Text] [Related]  

  • 47. Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.
    Brown DG; Bernstein PR; Griffin A; Wesolowski S; Labrecque D; Tremblay MC; Sylvester M; Mauger R; Edwards PD; Throner SR; Folmer JJ; Cacciola J; Scott C; Lazor LA; Pourashraf M; Santhakumar V; Potts WM; Sydserff S; Giguère P; Lévesque C; Dasser M; Groblewski T
    J Med Chem; 2014 Feb; 57(3):733-58. PubMed ID: 24410637
    [TBL] [Abstract][Full Text] [Related]  

  • 48. Effect of essential oils, such as raspberry ketone and its derivatives, on antiandrogenic activity based on in vitro reporter gene assay.
    Ogawa Y; Akamatsu M; Hotta Y; Hosoda A; Tamura H
    Bioorg Med Chem Lett; 2010 Apr; 20(7):2111-4. PubMed ID: 20226658
    [TBL] [Abstract][Full Text] [Related]  

  • 49. Screening of synthetic and natural product databases: Identification of novel androgens and antiandrogens.
    Bobach C; Tennstedt S; Palberg K; Denkert A; Brandt W; de Meijere A; Seliger B; Wessjohann LA
    Eur J Med Chem; 2015 Jan; 90():267-79. PubMed ID: 25461327
    [TBL] [Abstract][Full Text] [Related]  

  • 50. Design and synthesis of imidazoline derivatives active on glucose homeostasis in a rat model of type II diabetes. 2. Syntheses and biological activities of 1,4-dialkyl-, 1,4-dibenzyl, and 1-benzyl-4-alkyl-2-(4',5'-dihydro-1'H-imidazol-2'-yl)piperazines and isosteric analogues of imidazoline.
    Le Bihan G; Rondu F; Pelé-Tounian A; Wang X; Lidy S; Touboul E; Lamouri A; Dive G; Huet J; Pfeiffer B; Renard P; Guardiola-Lemaître B; Manéchez D; Pénicaud L; Ktorza A; Godfroid JJ
    J Med Chem; 1999 May; 42(9):1587-603. PubMed ID: 10229628
    [TBL] [Abstract][Full Text] [Related]  

  • 51. Modeling androgen receptor flexibility: a binding mode hypothesis of CYP17 inhibitors/antiandrogens for prostate cancer therapy.
    Gianti E; Zauhar RJ
    J Chem Inf Model; 2012 Oct; 52(10):2670-83. PubMed ID: 22924551
    [TBL] [Abstract][Full Text] [Related]  

  • 52. Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.
    Marcinkowska M; Kotańska M; Zagórska A; Śniecikowska J; Kubacka M; Siwek A; Bucki A; Pawłowski M; Bednarski M; Sapa J; Starek M; Dąbrowska M; Kołaczkowski M
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):536-545. PubMed ID: 29482394
    [TBL] [Abstract][Full Text] [Related]  

  • 53. Discovery and biological evaluation of novel androgen receptor antagonist for castration-resistant prostate cancer.
    Yu J; Zhang L; Yan G; Zhou P; Cao C; Zhou F; Li X; Chen Y
    Eur J Med Chem; 2019 Jun; 171():265-281. PubMed ID: 30925341
    [TBL] [Abstract][Full Text] [Related]  

  • 54. Piperazine analogs of naphthyridine-3-carboxamides and indole-2-carboxamides: novel 5-HT3 receptor antagonists with antidepressant-like activity.
    Dhar AK; Mahesh R; Jindal A; Bhatt S
    Arch Pharm (Weinheim); 2015 Jan; 348(1):34-45. PubMed ID: 25581677
    [TBL] [Abstract][Full Text] [Related]  

  • 55. Further optimization of novel pyrrole 3-carboxamides for targeting serotonin 5-HT(2A), 5-HT(2C), and the serotonin transporter as a potential antidepressant.
    Kang SY; Park EJ; Park WK; Kim HJ; Choi G; Jung ME; Seo HJ; Kim MJ; Pae AN; Kim J; Lee J
    Bioorg Med Chem; 2010 Aug; 18(16):6156-69. PubMed ID: 20637635
    [TBL] [Abstract][Full Text] [Related]  

  • 56. Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS).
    Asagarasu A; Matsui T; Hayashi H; Tamaoki S; Yamauchi Y; Sato M
    Chem Pharm Bull (Tokyo); 2009 Jan; 57(1):34-42. PubMed ID: 19122313
    [TBL] [Abstract][Full Text] [Related]  

  • 57. Trisubstituted pyrimidines as transient receptor potential vanilloid 1 (TRPV1) antagonists with improved solubility.
    Wang X; Chakrabarti PP; Ognyanov VI; Pettus LH; Tamir R; Tan H; Tang P; Treanor JJ; Gavva NR; Norman MH
    Bioorg Med Chem Lett; 2007 Dec; 17(23):6539-45. PubMed ID: 17937985
    [TBL] [Abstract][Full Text] [Related]  

  • 58. Deoxyribonucleic acid-binding ability of androgen receptors in whole cells: implications for the actions of androgens and antiandrogens.
    Kuil CW; Mulder E
    Endocrinology; 1996 May; 137(5):1870-7. PubMed ID: 8612526
    [TBL] [Abstract][Full Text] [Related]  

  • 59. The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.
    Perrone MG; Bleve L; Santandrea E; Vitale P; Niso M; Scilimati A
    ChemMedChem; 2009 Dec; 4(12):2080-97. PubMed ID: 19882697
    [TBL] [Abstract][Full Text] [Related]  

  • 60. Novel potent and selective central 5-HT3 receptor ligands provided with different intrinsic efficacy. 1. Mapping the central 5-HT3 receptor binding site by arylpiperazine derivatives.
    Cappelli A; Anzini M; Vomero S; Mennuni L; Makovec F; Doucet E; Hamon M; Bruni G; Romeo MR; Menziani MC; De Benedetti PG; Langer T
    J Med Chem; 1998 Feb; 41(5):728-41. PubMed ID: 9513601
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.