BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1028 related articles for article (PubMed ID: 15519281)

  • 1. Nrf2-Keap1 defines a physiologically important stress response mechanism.
    Motohashi H; Yamamoto M
    Trends Mol Med; 2004 Nov; 10(11):549-57. PubMed ID: 15519281
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism.
    Velichkova M; Hasson T
    Mol Cell Biol; 2005 Jun; 25(11):4501-13. PubMed ID: 15899855
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
    Wakabayashi N; Itoh K; Wakabayashi J; Motohashi H; Noda S; Takahashi S; Imakado S; Kotsuji T; Otsuka F; Roop DR; Harada T; Engel JD; Yamamoto M
    Nat Genet; 2003 Nov; 35(3):238-45. PubMed ID: 14517554
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Unique function of the Nrf2-Keap1 pathway in the inducible expression of antioxidant and detoxifying enzymes.
    Kobayashi A; Ohta T; Yamamoto M
    Methods Enzymol; 2004; 378():273-86. PubMed ID: 15038975
    [No Abstract]   [Full Text] [Related]  

  • 5. The Keap1-Nrf2 system as an in vivo sensor for electrophiles.
    Uruno A; Motohashi H
    Nitric Oxide; 2011 Aug; 25(2):153-60. PubMed ID: 21385624
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
    Wakabayashi N; Dinkova-Kostova AT; Holtzclaw WD; Kang MI; Kobayashi A; Yamamoto M; Kensler TW; Talalay P
    Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2040-5. PubMed ID: 14764894
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles.
    Itoh K; Tong KI; Yamamoto M
    Free Radic Biol Med; 2004 May; 36(10):1208-13. PubMed ID: 15110385
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
    Ohkoshi A; Suzuki T; Ono M; Kobayashi T; Yamamoto M
    Cancer Prev Res (Phila); 2013 Feb; 6(2):149-59. PubMed ID: 23250896
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of different exercise durations on Keap1-Nrf2-ARE pathway activation in mouse skeletal muscle.
    Li T; He S; Liu S; Kong Z; Wang J; Zhang Y
    Free Radic Res; 2015 Oct; 49(10):1269-74. PubMed ID: 26118597
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.
    Karapetian RN; Evstafieva AG; Abaeva IS; Chichkova NV; Filonov GS; Rubtsov YP; Sukhacheva EA; Melnikov SV; Schneider U; Wanker EE; Vartapetian AB
    Mol Cell Biol; 2005 Feb; 25(3):1089-99. PubMed ID: 15657435
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Small Maf proteins serve as transcriptional cofactors for keratinocyte differentiation in the Keap1-Nrf2 regulatory pathway.
    Motohashi H; Katsuoka F; Engel JD; Yamamoto M
    Proc Natl Acad Sci U S A; 2004 Apr; 101(17):6379-84. PubMed ID: 15087497
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum.
    Zhang Y; Crouch DH; Yamamoto M; Hayes JD
    Biochem J; 2006 Nov; 399(3):373-85. PubMed ID: 16872277
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association.
    He X; Lin GX; Chen MG; Zhang JX; Ma Q
    Toxicol Sci; 2007 Jul; 98(1):298-309. PubMed ID: 17420218
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Nrf2-Keap1 defence pathway: role in protection against drug-induced toxicity.
    Copple IM; Goldring CE; Kitteringham NR; Park BK
    Toxicology; 2008 Apr; 246(1):24-33. PubMed ID: 18083283
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway.
    Kensler TW; Wakabayashi N; Biswal S
    Annu Rev Pharmacol Toxicol; 2007; 47():89-116. PubMed ID: 16968214
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes.
    Kang MI; Kobayashi A; Wakabayashi N; Kim SG; Yamamoto M
    Proc Natl Acad Sci U S A; 2004 Feb; 101(7):2046-51. PubMed ID: 14764898
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Increased Nrf2 activation in livers from Keap1-knockdown mice increases expression of cytoprotective genes that detoxify electrophiles more than those that detoxify reactive oxygen species.
    Reisman SA; Yeager RL; Yamamoto M; Klaassen CD
    Toxicol Sci; 2009 Mar; 108(1):35-47. PubMed ID: 19129213
    [TBL] [Abstract][Full Text] [Related]  

  • 18. [Oxidative/electrophilic stress sensor Keap1 regulates the rapid turnover of transcripition factor Nrf2].
    Kobayashi A; Tong KI
    Tanpakushitsu Kakusan Koso; 2006 Aug; 51(10 Suppl):1304-8. PubMed ID: 16922392
    [No Abstract]   [Full Text] [Related]  

  • 19. Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation.
    Keleku-Lukwete N; Suzuki M; Otsuki A; Tsuchida K; Katayama S; Hayashi M; Naganuma E; Moriguchi T; Tanabe O; Engel JD; Imaizumi M; Yamamoto M
    Proc Natl Acad Sci U S A; 2015 Sep; 112(39):12169-74. PubMed ID: 26371321
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nrf2 protects against furosemide-induced hepatotoxicity.
    Qu Q; Liu J; Zhou HH; Klaassen CD
    Toxicology; 2014 Oct; 324():35-42. PubMed ID: 24813929
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 52.