253 related articles for article (PubMed ID: 15522264)
21. Metabolism of three pharmacologically active drugs in isolated human and rat hepatocytes: analysis of interspecies variability and comparison with metabolism in vivo.
Sandker GW; Vos RM; Delbressine LP; Slooff MJ; Meijer DK; Groothuis GM
Xenobiotica; 1994 Feb; 24(2):143-55. PubMed ID: 8017089
[TBL] [Abstract][Full Text] [Related]
22. Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells.
Aninat C; Piton A; Glaise D; Le Charpentier T; Langouët S; Morel F; Guguen-Guillouzo C; Guillouzo A
Drug Metab Dispos; 2006 Jan; 34(1):75-83. PubMed ID: 16204462
[TBL] [Abstract][Full Text] [Related]
23. [The human hepatocyte: I. A model for studying metabolism and toxicity of xenobiotics].
Kosina P; Dvorák Z; Walterová D
Ceska Slov Farm; 1999 Mar; 48(2):65-71. PubMed ID: 10376418
[TBL] [Abstract][Full Text] [Related]
24. Metabolism Comparative Cytotoxicity Assay (MCCA) and Cytotoxic Metabolic Pathway Identification Assay (CMPIA) with cryopreserved human hepatocytes for the evaluation of metabolism-based cytotoxicity in vitro: proof-of-concept study with aflatoxin B1.
Li AP
Chem Biol Interact; 2009 Apr; 179(1):4-8. PubMed ID: 18950609
[TBL] [Abstract][Full Text] [Related]
25. Biotransformation enzymes as determinants of xenobiotic toxicity in domestic animals.
Nebbia C
Vet J; 2001 May; 161(3):238-52. PubMed ID: 11352482
[TBL] [Abstract][Full Text] [Related]
26. Modeling xenobiotic susceptibility to hepatotoxicity using an in vitro oxidative stress inflammation model.
MacAllister SL; Maruf AA; Wan L; Chung E; O'Brien P
Can J Physiol Pharmacol; 2013 Mar; 91(3):236-40. PubMed ID: 23537437
[TBL] [Abstract][Full Text] [Related]
27. Aroclor 1254 induced cytotoxicity and mitochondrial dysfunction in isolated rat hepatocytes.
Aly HA; Domènech O
Toxicology; 2009 Aug; 262(3):175-83. PubMed ID: 19486918
[TBL] [Abstract][Full Text] [Related]
28. A microfluidic 3D hepatocyte chip for drug toxicity testing.
Toh YC; Lim TC; Tai D; Xiao G; van Noort D; Yu H
Lab Chip; 2009 Jul; 9(14):2026-35. PubMed ID: 19568671
[TBL] [Abstract][Full Text] [Related]
29. General review on in vitro hepatocyte models and their applications.
Guguen-Guillouzo C; Guillouzo A
Methods Mol Biol; 2010; 640():1-40. PubMed ID: 20645044
[TBL] [Abstract][Full Text] [Related]
30. From known knowns to known unknowns: predicting in vivo drug metabolites.
Pelkonen O; Tolonen A; Korjamo T; Turpeinen M; Raunio H
Bioanalysis; 2009 May; 1(2):393-414. PubMed ID: 21083174
[TBL] [Abstract][Full Text] [Related]
31. Modeling inflammation-drug interactions in vitro: a rat Kupffer cell-hepatocyte coculture system.
Tukov FF; Maddox JF; Amacher DE; Bobrowski WF; Roth RA; Ganey PE
Toxicol In Vitro; 2006 Dec; 20(8):1488-99. PubMed ID: 16782301
[TBL] [Abstract][Full Text] [Related]
32. Accelerated cytotoxicity mechanism screening using drug metabolising enzyme modulators.
O'Brien PJ; Siraki AG
Curr Drug Metab; 2005 Apr; 6(2):101-9. PubMed ID: 15853762
[TBL] [Abstract][Full Text] [Related]
33. Blood monocyte-derived neohepatocytes as in vitro test system for drug metabolism.
Ehnert S; Nussler AK; Lehmann A; Dooley S
Drug Metab Dispos; 2008 Sep; 36(9):1922-9. PubMed ID: 18559486
[TBL] [Abstract][Full Text] [Related]
34. Use of hepatocytes to assess the contribution of hepatic uptake to clearance in vivo.
Soars MG; Grime K; Sproston JL; Webborn PJ; Riley RJ
Drug Metab Dispos; 2007 Jun; 35(6):859-65. PubMed ID: 17344337
[TBL] [Abstract][Full Text] [Related]
35. Human hepatocytes: isolation, cryopreservation and applications in drug development.
Li AP
Chem Biol Interact; 2007 May; 168(1):16-29. PubMed ID: 17270162
[TBL] [Abstract][Full Text] [Related]
36. A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo.
Kienhuis AS; van de Poll MC; Dejong CH; Gottschalk R; van Herwijnen M; Boorsma A; Kleinjans JC; Stierum RH; van Delft JH
Toxicol In Vitro; 2009 Sep; 23(6):1163-9. PubMed ID: 19527782
[TBL] [Abstract][Full Text] [Related]
37. Effect of chronic ethanol exposure on the hepatotoxicity of ecstasy in mice: an ex vivo study.
Pontes H; Santos-Marques MJ; Fernandes E; Duarte JA; Remião F; Carvalho F; Bastos ML
Toxicol In Vitro; 2008 Jun; 22(4):910-20. PubMed ID: 18325728
[TBL] [Abstract][Full Text] [Related]
38. Application of a generic physiologically based pharmacokinetic model to the estimation of xenobiotic levels in human plasma.
Brightman FA; Leahy DE; Searle GE; Thomas S
Drug Metab Dispos; 2006 Jan; 34(1):94-101. PubMed ID: 16221756
[TBL] [Abstract][Full Text] [Related]
39. Enhanced Metabolizing Activity of Human ES Cell-Derived Hepatocytes Using a 3D Culture System with Repeated Exposures to Xenobiotics.
Kim JH; Jang YJ; An SY; Son J; Lee J; Lee G; Park JY; Park HJ; Hwang DY; Kim JH; Han J
Toxicol Sci; 2015 Sep; 147(1):190-206. PubMed ID: 26089346
[TBL] [Abstract][Full Text] [Related]
40. Comparison of coumarin-induced toxicity between sandwich-cultured primary rat hepatocytes and rats in vivo: a toxicogenomics approach.
Kienhuis AS; Wortelboer HM; Hoflack JC; Moonen EJ; Kleinjans JC; van Ommen B; van Delft JH; Stierum RH
Drug Metab Dispos; 2006 Dec; 34(12):2083-90. PubMed ID: 16963487
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]