113 related articles for article (PubMed ID: 15542063)
1. The iSH2 domain of PI 3-kinase is a rigid tether for p110 and not a conformational switch.
Fu Z; Aronoff-Spencer E; Wu H; Gerfen GJ; Backer JM
Arch Biochem Biophys; 2004 Dec; 432(2):244-51. PubMed ID: 15542063
[TBL] [Abstract][Full Text] [Related]
2. Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit.
Shekar SC; Wu H; Fu Z; Yip SC; Nagajyothi ; Cahill SM; Girvin ME; Backer JM
J Biol Chem; 2005 Jul; 280(30):27850-5. PubMed ID: 15932879
[TBL] [Abstract][Full Text] [Related]
3. The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling.
Fu Z; Aronoff-Spencer E; Backer JM; Gerfen GJ
Proc Natl Acad Sci U S A; 2003 Mar; 100(6):3275-80. PubMed ID: 12629217
[TBL] [Abstract][Full Text] [Related]
4. The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder.
Sen KI; Wu H; Backer JM; Gerfen GJ
Biochemistry; 2010 Mar; 49(10):2159-66. PubMed ID: 20131869
[TBL] [Abstract][Full Text] [Related]
5. Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants.
Wu H; Shekar SC; Flinn RJ; El-Sibai M; Jaiswal BS; Sen KI; Janakiraman V; Seshagiri S; Gerfen GJ; Girvin ME; Backer JM
Proc Natl Acad Sci U S A; 2009 Dec; 106(48):20258-63. PubMed ID: 19915146
[TBL] [Abstract][Full Text] [Related]
6. Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains.
Yu J; Wjasow C; Backer JM
J Biol Chem; 1998 Nov; 273(46):30199-203. PubMed ID: 9804776
[TBL] [Abstract][Full Text] [Related]
7. Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits.
Holt KH; Olson L; Moye-Rowley WS; Pessin JE
Mol Cell Biol; 1994 Jan; 14(1):42-9. PubMed ID: 8264609
[TBL] [Abstract][Full Text] [Related]
8. Solution structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase.
Siegal G; Davis B; Kristensen SM; Sankar A; Linacre J; Stein RC; Panayotou G; Waterfield MD; Driscoll PC
J Mol Biol; 1998 Feb; 276(2):461-78. PubMed ID: 9512716
[TBL] [Abstract][Full Text] [Related]
9. Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).
Burke JE; Williams RL
Adv Biol Regul; 2013 Jan; 53(1):97-110. PubMed ID: 23194976
[TBL] [Abstract][Full Text] [Related]
10. Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.
Hu P; Schlessinger J
Mol Cell Biol; 1994 Apr; 14(4):2577-83. PubMed ID: 8139559
[TBL] [Abstract][Full Text] [Related]
11. Structure of the iSH2 domain of human phosphatidylinositol 3-kinase p85β subunit reveals conformational plasticity in the interhelical turn region.
Schauder C; Ma LC; Krug RM; Montelione GT; Guan R
Acta Crystallogr Sect F Struct Biol Cryst Commun; 2010 Dec; 66(Pt 12):1567-71. PubMed ID: 21139197
[TBL] [Abstract][Full Text] [Related]
12. Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Zhang X; Vadas O; Perisic O; Anderson KE; Clark J; Hawkins PT; Stephens LR; Williams RL
Mol Cell; 2011 Mar; 41(5):567-78. PubMed ID: 21362552
[TBL] [Abstract][Full Text] [Related]
13. Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation.
Hale BG; Batty IH; Downes CP; Randall RE
J Biol Chem; 2008 Jan; 283(3):1372-1380. PubMed ID: 18029356
[TBL] [Abstract][Full Text] [Related]
14. A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.
Dbouk HA; Pang H; Fiser A; Backer JM
Proc Natl Acad Sci U S A; 2010 Nov; 107(46):19897-902. PubMed ID: 21030680
[TBL] [Abstract][Full Text] [Related]
15. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.
Klippel A; Escobedo JA; Hirano M; Williams LT
Mol Cell Biol; 1994 Apr; 14(4):2675-85. PubMed ID: 8139567
[TBL] [Abstract][Full Text] [Related]
16. N-terminal domains of the class ia phosphoinositide 3-kinase regulatory subunit play a role in cytoskeletal but not mitogenic signaling.
Hill KM; Huang Y; Yip SC; Yu J; Segall JE; Backer JM
J Biol Chem; 2001 May; 276(19):16374-8. PubMed ID: 11278326
[TBL] [Abstract][Full Text] [Related]
17. Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein.
Hale BG; Kerry PS; Jackson D; Precious BL; Gray A; Killip MJ; Randall RE; Russell RJ
Proc Natl Acad Sci U S A; 2010 Feb; 107(5):1954-9. PubMed ID: 20133840
[TBL] [Abstract][Full Text] [Related]
18. Structural basis of the nic96 subcomplex organization in the nuclear pore channel.
Schrader N; Stelter P; Flemming D; Kunze R; Hurt E; Vetter IR
Mol Cell; 2008 Jan; 29(1):46-55. PubMed ID: 18206968
[TBL] [Abstract][Full Text] [Related]
19. The Nsp1p carboxy-terminal domain is organized into functionally distinct coiled-coil regions required for assembly of nucleoporin subcomplexes and nucleocytoplasmic transport.
Bailer SM; Balduf C; Hurt E
Mol Cell Biol; 2001 Dec; 21(23):7944-55. PubMed ID: 11689687
[TBL] [Abstract][Full Text] [Related]
20. Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions.
Peng H; Begg GE; Schultz DC; Friedman JR; Jensen DE; Speicher DW; Rauscher FJ
J Mol Biol; 2000 Feb; 295(5):1139-62. PubMed ID: 10653693
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
