145 related articles for article (PubMed ID: 15566096)
1. Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.
Duringer JM; Buhler DR; Craig AM
Am J Vet Res; 2004 Nov; 65(11):1563-72. PubMed ID: 15566096
[TBL] [Abstract][Full Text] [Related]
2. Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
Huan JY; Miranda CL; Buhler DR; Cheeke PR
Toxicol Lett; 1998 Oct; 99(2):127-37. PubMed ID: 9817084
[TBL] [Abstract][Full Text] [Related]
3. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
Wang YP; Yan J; Fu PP; Chou MW
Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625
[TBL] [Abstract][Full Text] [Related]
4. The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs.
Chung WG; Buhler DR
Toxicol Appl Pharmacol; 1994 Aug; 127(2):314-9. PubMed ID: 8048076
[TBL] [Abstract][Full Text] [Related]
5. The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters.
Huan JY; Miranda CL; Buhler DR; Cheeke PR
Toxicol Appl Pharmacol; 1998 Aug; 151(2):229-35. PubMed ID: 9707499
[TBL] [Abstract][Full Text] [Related]
6. Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.
Miranda CL; Reed RL; Guengerich FP; Buhler DR
Carcinogenesis; 1991 Mar; 12(3):515-9. PubMed ID: 2009596
[TBL] [Abstract][Full Text] [Related]
7. Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine.
Winter CK; Segall HJ; Jones AD
Comp Biochem Physiol C Comp Pharmacol Toxicol; 1988; 90(2):429-33. PubMed ID: 2903002
[TBL] [Abstract][Full Text] [Related]
8. Microsomal formation of a pyrrolic alcohol glutathione conjugate of the pyrrolizidine alkaloid senecionine.
Reed RL; Miranda CL; Kedzierski B; Henderson MC; Buhler DR
Xenobiotica; 1992 Nov; 22(11):1321-7. PubMed ID: 1492424
[TBL] [Abstract][Full Text] [Related]
9. Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.
Xia Q; Yan J; Chou MW; Fu PP
Toxicol Lett; 2008 May; 178(2):77-82. PubMed ID: 18395999
[TBL] [Abstract][Full Text] [Related]
10. New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro.
Muluneh F; Häkkinen MR; El-Dairi R; Pasanen M; Juvonen RO
Rapid Commun Mass Spectrom; 2018 Aug; 32(16):1344-1352. PubMed ID: 29788543
[TBL] [Abstract][Full Text] [Related]
11. Differential metabolism of the pyrrolizidine alkaloid, senecionine, in Fischer 344 and Sprague-Dawley rats.
Chung WG; Buhler DR
Arch Pharm Res; 2004 May; 27(5):547-53. PubMed ID: 15202562
[TBL] [Abstract][Full Text] [Related]
12. Flavin-containing monooxygenase: a major detoxifying enzyme for the pyrrolizidine alkaloid senecionine in guinea pig tissues.
Miranda CL; Chung W; Reed RE; Zhao X; Henderson MC; Wang JL; Williams DE; Buhler DR
Biochem Biophys Res Commun; 1991 Jul; 178(2):546-52. PubMed ID: 1907134
[TBL] [Abstract][Full Text] [Related]
13. Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine.
Chou MW; Wang YP; Yan J; Yang YC; Beger RD; Williams LD; Doerge DR; Fu PP
Toxicol Lett; 2003 Dec; 145(3):239-47. PubMed ID: 14580895
[TBL] [Abstract][Full Text] [Related]
14. Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts.
Yan J; Xia Q; Chou MW; Fu PP
Toxicol Ind Health; 2008 Apr; 24(3):181-8. PubMed ID: 18842697
[TBL] [Abstract][Full Text] [Related]
15. Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
Williams DE; Reed RL; Kedzierski B; Dannan GA; Guengerich FP; Buhler DR
Drug Metab Dispos; 1989; 17(4):387-92. PubMed ID: 2571477
[TBL] [Abstract][Full Text] [Related]
16. 7-cysteine-pyrrole conjugate: A new potential DNA reactive metabolite of pyrrolizidine alkaloids.
He X; Xia Q; Ma L; Fu PP
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev; 2016; 34(1):57-76. PubMed ID: 26761716
[TBL] [Abstract][Full Text] [Related]
17. 9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.
Chen M; Li L; Zhong D; Shen S; Zheng J; Chen X
Chem Res Toxicol; 2016 Feb; 29(2):180-9. PubMed ID: 26761523
[TBL] [Abstract][Full Text] [Related]
18. A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig.
Chung WG; Miranda CL; Buhler DR
Xenobiotica; 1995 Sep; 25(9):929-39. PubMed ID: 8553686
[TBL] [Abstract][Full Text] [Related]
19. Pyrrolizidine Alkaloid Secondary Pyrrolic Metabolites Construct Multiple Activation Pathways Leading to DNA Adduct Formation and Potential Liver Tumor Initiation.
Xia Q; He X; Ma L; Chen S; Fu PP
Chem Res Toxicol; 2018 Jul; 31(7):619-628. PubMed ID: 29855181
[TBL] [Abstract][Full Text] [Related]
20. The formation of 6,7-dihydro-7-hydroxy-1-hydroxy-methyl-5H-pyrrolizine, a metabolite of pyrrolizidine alkaloids.
Kedzierski B; Buhler DR
Chem Biol Interact; 1986 Feb; 57(2):217-22. PubMed ID: 3955792
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
