1548 related articles for article (PubMed ID: 15574182)
21. Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
Lu HR; Hermans AN; Gallacher DJ
Br J Pharmacol; 2012 Jun; 166(4):1490-502. PubMed ID: 22300168
[TBL] [Abstract][Full Text] [Related]
22. Inhibition of human ether-a-go-go-related gene K+ channel and IKr of guinea pig cardiomyocytes by antipsychotic drug trifluoperazine.
Choi SY; Koh YS; Jo SH
J Pharmacol Exp Ther; 2005 May; 313(2):888-95. PubMed ID: 15722405
[TBL] [Abstract][Full Text] [Related]
23. A new biomarker--index of cardiac electrophysiological balance (iCEB)--plays an important role in drug-induced cardiac arrhythmias: beyond QT-prolongation and Torsades de Pointes (TdPs).
Lu HR; Yan GX; Gallacher DJ
J Pharmacol Toxicol Methods; 2013; 68(2):250-259. PubMed ID: 23337247
[TBL] [Abstract][Full Text] [Related]
24. The [3H]dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+]o.
Diaz GJ; Daniell K; Leitza ST; Martin RL; Su Z; McDermott JS; Cox BF; Gintant GA
J Pharmacol Toxicol Methods; 2004; 50(3):187-99. PubMed ID: 15519905
[TBL] [Abstract][Full Text] [Related]
25. Evaluation of Possible Proarrhythmic Potency: Comparison of the Effect of Dofetilide, Cisapride, Sotalol, Terfenadine, and Verapamil on hERG and Native IKr Currents and on Cardiac Action Potential.
Orvos P; Kohajda Z; Szlovák J; Gazdag P; Árpádffy-Lovas T; Tóth D; Geramipour A; Tálosi L; Jost N; Varró A; Virág L
Toxicol Sci; 2019 Apr; 168(2):365-380. PubMed ID: 30561737
[TBL] [Abstract][Full Text] [Related]
26. High affinity open channel block by dofetilide of HERG expressed in a human cell line.
Snyders DJ; Chaudhary A
Mol Pharmacol; 1996 Jun; 49(6):949-55. PubMed ID: 8649354
[TBL] [Abstract][Full Text] [Related]
27. QT interval prolongation and cardiac risk assessment for novel drugs.
Picard S; Lacroix P
Curr Opin Investig Drugs; 2003 Mar; 4(3):303-8. PubMed ID: 12735231
[TBL] [Abstract][Full Text] [Related]
28. L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation.
Guo D; Zhao X; Wu Y; Liu T; Kowey PR; Yan GX
J Cardiovasc Electrophysiol; 2007 Feb; 18(2):196-203. PubMed ID: 17212595
[TBL] [Abstract][Full Text] [Related]
29. Effect of azelastine on cardiac repolarization of guinea-pig cardiomyocytes, hERG K⁺ channel, and human L-type and T-type Ca²⁺ channel.
Park MH; Lee SH; Chu DH; Won KH; Choi BH; Choe H; Jo SH
J Pharmacol Sci; 2013 Sep; 123(1):67-77. PubMed ID: 24005046
[TBL] [Abstract][Full Text] [Related]
30. Human embryonic stem cell derived cardiac myocytes detect hERG-mediated repolarization effects, but not Nav1.5 induced depolarization delay.
Qu Y; Gao B; Fang M; Vargas HM
J Pharmacol Toxicol Methods; 2013; 68(1):74-81. PubMed ID: 23518063
[TBL] [Abstract][Full Text] [Related]
31. Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval.
Drolet B; Khalifa M; Daleau P; Hamelin BA; Turgeon J
Circulation; 1998 Jan; 97(2):204-10. PubMed ID: 9445174
[TBL] [Abstract][Full Text] [Related]
32. Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
Fossa AA; Wisialowski T; Wolfgang E; Wang E; Avery M; Raunig DL; Fermini B
Eur J Pharmacol; 2004 Feb; 486(2):209-21. PubMed ID: 14975710
[TBL] [Abstract][Full Text] [Related]
33. Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential.
Hancox JC; Levi AJ; Witchel HJ
Pflugers Arch; 1998 Nov; 436(6):843-53. PubMed ID: 9799397
[TBL] [Abstract][Full Text] [Related]
34. Role of a KCNH2 polymorphism (R1047 L) in dofetilide-induced Torsades de Pointes.
Sun Z; Milos PM; Thompson JF; Lloyd DB; Mank-Seymour A; Richmond J; Cordes JS; Zhou J
J Mol Cell Cardiol; 2004 Nov; 37(5):1031-9. PubMed ID: 15522280
[TBL] [Abstract][Full Text] [Related]
35. A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.
Jonker DM; Kenna LA; Leishman D; Wallis R; Milligan PA; Jonsson EN
Clin Pharmacol Ther; 2005 Jun; 77(6):572-82. PubMed ID: 15961988
[TBL] [Abstract][Full Text] [Related]
36. Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines.
Lu HR; Vlaminckx E; Hermans AN; Rohrbacher J; Van Ammel K; Towart R; Pugsley M; Gallacher DJ
Br J Pharmacol; 2008 Aug; 154(7):1427-38. PubMed ID: 18493243
[TBL] [Abstract][Full Text] [Related]
37. Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity.
Zhou J; Augelli-Szafran CE; Bradley JA; Chen X; Koci BJ; Volberg WA; Sun Z; Cordes JS
Mol Pharmacol; 2005 Sep; 68(3):876-84. PubMed ID: 15976038
[TBL] [Abstract][Full Text] [Related]
38. Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.
Cheng HC; Incardona J
J Pharmacol Toxicol Methods; 2009; 60(2):174-84. PubMed ID: 19524054
[TBL] [Abstract][Full Text] [Related]
39. Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation.
Guo L; Guthrie H
J Pharmacol Toxicol Methods; 2005; 52(1):123-35. PubMed ID: 15936217
[TBL] [Abstract][Full Text] [Related]
40. RSD1235 blocks late INa and suppresses early afterdepolarizations and torsades de pointes induced by class III agents.
Orth PM; Hesketh JC; Mak CK; Yang Y; Lin S; Beatch GN; Ezrin AM; Fedida D
Cardiovasc Res; 2006 Jun; 70(3):486-96. PubMed ID: 16545351
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]