These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 15579463)

  • 1. Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry.
    Shin I; Rotty J; Wu FY; Arteaga CL
    J Biol Chem; 2005 Feb; 280(7):6055-63. PubMed ID: 15579463
    [TBL] [Abstract][Full Text] [Related]  

  • 2. PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization.
    Shin I; Yakes FM; Rojo F; Shin NY; Bakin AV; Baselga J; Arteaga CL
    Nat Med; 2002 Oct; 8(10):1145-52. PubMed ID: 12244301
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1).
    Sekimoto T; Fukumoto M; Yoneda Y
    EMBO J; 2004 May; 23(9):1934-42. PubMed ID: 15057270
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export.
    Ishida N; Hara T; Kamura T; Yoshida M; Nakayama K; Nakayama KI
    J Biol Chem; 2002 Apr; 277(17):14355-8. PubMed ID: 11889117
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer.
    Viglietto G; Motti ML; Bruni P; Melillo RM; D'Alessio A; Califano D; Vinci F; Chiappetta G; Tsichlis P; Bellacosa A; Fusco A; Santoro M
    Nat Med; 2002 Oct; 8(10):1136-44. PubMed ID: 12244303
    [TBL] [Abstract][Full Text] [Related]  

  • 6. PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest.
    Liang J; Zubovitz J; Petrocelli T; Kotchetkov R; Connor MK; Han K; Lee JH; Ciarallo S; Catzavelos C; Beniston R; Franssen E; Slingerland JM
    Nat Med; 2002 Oct; 8(10):1153-60. PubMed ID: 12244302
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis.
    Connor MK; Kotchetkov R; Cariou S; Resch A; Lupetti R; Beniston RG; Melchior F; Hengst L; Slingerland JM
    Mol Biol Cell; 2003 Jan; 14(1):201-13. PubMed ID: 12529437
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.
    Guan X; Chen L; Wang J; Geng H; Chu X; Zhang Q; Du L; De W
    Biochem Biophys Res Commun; 2006 Sep; 347(3):601-7. PubMed ID: 16842750
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation.
    Kotake Y; Nakayama K; Ishida N; Nakayama KI
    J Biol Chem; 2005 Jan; 280(2):1095-102. PubMed ID: 15528185
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization.
    Fujita N; Sato S; Katayama K; Tsuruo T
    J Biol Chem; 2002 Aug; 277(32):28706-13. PubMed ID: 12042314
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2.
    Lents NH; Keenan SM; Bellone C; Baldassare JJ
    J Biol Chem; 2002 Dec; 277(49):47469-75. PubMed ID: 12359725
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression.
    Boehm M; Yoshimoto T; Crook MF; Nallamshetty S; True A; Nabel GJ; Nabel EG
    EMBO J; 2002 Jul; 21(13):3390-401. PubMed ID: 12093740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase.
    Deng X; Mercer SE; Shah S; Ewton DZ; Friedman E
    J Biol Chem; 2004 May; 279(21):22498-504. PubMed ID: 15010468
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Complex regulation of the cyclin-dependent kinase inhibitor p27kip1 in thyroid cancer cells by the PI3K/AKT pathway: regulation of p27kip1 expression and localization.
    Motti ML; Califano D; Troncone G; De Marco C; Migliaccio I; Palmieri E; Pezzullo L; Palombini L; Fusco A; Viglietto G
    Am J Pathol; 2005 Mar; 166(3):737-49. PubMed ID: 15743786
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Regulatory role of PI 3-kinase on expression of Cdk4 and p27, nuclear localization of Cdk4, and phosphorylation of p27 in corneal endothelial cells.
    Lee HT; Kay EP
    Invest Ophthalmol Vis Sci; 2003 Apr; 44(4):1521-8. PubMed ID: 12657588
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia.
    Min YH; Cheong JW; Kim JY; Eom JI; Lee ST; Hahn JS; Ko YW; Lee MH
    Cancer Res; 2004 Aug; 64(15):5225-31. PubMed ID: 15289327
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability.
    Ishida N; Kitagawa M; Hatakeyama S; Nakayama K
    J Biol Chem; 2000 Aug; 275(33):25146-54. PubMed ID: 10831586
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines.
    Box AH; Demetrick DJ
    Carcinogenesis; 2004 Dec; 25(12):2325-35. PubMed ID: 15347600
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways.
    Lenferink AE; Busse D; Flanagan WM; Yakes FM; Arteaga CL
    Cancer Res; 2001 Sep; 61(17):6583-91. PubMed ID: 11522658
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Estrogens down-regulate p27Kip1 in breast cancer cells through Skp2 and through nuclear export mediated by the ERK pathway.
    Foster JS; Fernando RI; Ishida N; Nakayama KI; Wimalasena J
    J Biol Chem; 2003 Oct; 278(42):41355-66. PubMed ID: 12904306
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.