BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 15582435)

  • 1. Design, synthesis, and biological evaluation of achiral analogs of duocarmycin SA.
    Daniell K; Stewart M; Madsen E; Le M; Handl H; Brooks N; Kiakos K; Hartley JA; Lee M
    Bioorg Med Chem Lett; 2005 Jan; 15(1):177-80. PubMed ID: 15582435
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
    Kupchinsky S; Centioni S; Howard T; Trzupek J; Roller S; Carnahan V; Townes H; Purnell B; Price C; Handl H; Summerville K; Johnson K; Toth J; Hudson S; Kiakos K; Hartley JA; Lee M
    Bioorg Med Chem; 2004 Dec; 12(23):6221-36. PubMed ID: 15519165
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A novel class of in vivo active anticancer agents: achiral seco-amino- and seco-hydroxycyclopropylbenz[e]indolone (seco-CBI) analogues of the duocarmycins and CC-1065.
    Sato A; McNulty L; Cox K; Kim S; Scott A; Daniell K; Summerville K; Price C; Hudson S; Kiakos K; Hartley JA; Asao T; Lee M
    J Med Chem; 2005 Jun; 48(11):3903-18. PubMed ID: 15916443
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and biological studies of different duocarmycin based glycosidic prodrugs for their use in the antibody-directed enzyme prodrug therapy.
    Tietze LF; Schuster HJ; Krewer B; Schuberth I
    J Med Chem; 2009 Jan; 52(2):537-43. PubMed ID: 19143570
    [TBL] [Abstract][Full Text] [Related]  

  • 5. DNA sequence selective adenine alkylation, mechanism of adduct repair, and in vivo antitumor activity of the novel achiral seco-amino-cyclopropylbenz[e]indolone analogue of duocarmycin AS-I-145.
    Kiakos K; Sato A; Asao T; McHugh PJ; Lee M; Hartley JA
    Mol Cancer Ther; 2007 Oct; 6(10):2708-18. PubMed ID: 17938264
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Selective treatment of cancer: synthesis, biological evaluation and structural elucidation of novel analogues of the antibiotic CC-1065 and the duocarmycins.
    Tietze LF; Major F; Schuberth I; Spiegl DA; Krewer B; Maksimenka K; Bringmann G; Magull J
    Chemistry; 2007; 13(16):4396-409. PubMed ID: 17455190
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Asymmetric synthesis and biological evaluation of glycosidic prodrugs for a selective cancer therapy.
    Tietze LF; von Hof JM; Krewer B; Müller M; Major F; Schuster HJ; Schuberth I; Alves F
    ChemMedChem; 2008 Dec; 3(12):1946-55. PubMed ID: 19021160
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.
    Patil PC; Satam V; Lee M
    Anticancer Agents Med Chem; 2015; 15(5):616-30. PubMed ID: 25511515
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Duocarmycin-based prodrugs for cancer prodrug monotherapy.
    Tietze LF; Schuster HJ; Schmuck K; Schuberth I; Alves F
    Bioorg Med Chem; 2008 Jun; 16(12):6312-8. PubMed ID: 18524605
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Sequence-specific alkylation of double-strand human telomere repeat sequence by pyrrole-imidazole polyamides with indole linkers.
    Sasaki S; Bando T; Minoshima M; Shimizu T; Shinohara K; Takaoka T; Sugiyama H
    J Am Chem Soc; 2006 Sep; 128(37):12162-8. PubMed ID: 16967966
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety.
    Pinna GA; Murineddu G; Murruzzu C; Zuco V; Zunino F; Cappelletti G; Artali R; Cignarella G; Solano L; Villa S
    ChemMedChem; 2009 Jun; 4(6):998-1009. PubMed ID: 19291736
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
    Chanda PB; Boyle KE; Brody DM; Shukla V; Boger DL
    Bioorg Med Chem; 2016 Oct; 24(20):4779-4786. PubMed ID: 27221071
    [TBL] [Abstract][Full Text] [Related]  

  • 13. DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).
    Purnell B; Sato A; O'kelley A; Price C; Summerville K; Hudson S; O'hare C; Kiakos K; Asao T; Lee M; Hartley JA
    Bioorg Med Chem Lett; 2006 Nov; 16(21):5677-81. PubMed ID: 16919946
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis of the first spacer containing prodrug of a duocarmycin analogue and determination of its biological activity.
    Schuster HJ; Krewer B; von Hof JM; Schmuck K; Schuberth I; Alves F; Tietze LF
    Org Biomol Chem; 2010 Apr; 8(8):1833-42. PubMed ID: 20449487
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A novel achiral seco-amino-cyclopropylindoline (CI) analog of CC-1065 and the duocarmycins: design, synthesis and biological studies.
    Toth JL; Trzupek JD; Flores LV; Kiakos K; Hartley JA; Pennington WT; Lee M
    Med Chem; 2005 Jan; 1(1):13-9. PubMed ID: 16789881
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design, synthesis, and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates as anticancer agents.
    Wang JJ; Shen YK; Hu WP; Hsieh MC; Lin FL; Hsu MK; Hsu MH
    J Med Chem; 2006 Feb; 49(4):1442-9. PubMed ID: 16480280
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and antiproliferative activity of benzyl and phenethyl analogs of makaluvamines.
    Shinkre BA; Raisch KP; Fan L; Velu SE
    Bioorg Med Chem; 2008 Mar; 16(5):2541-9. PubMed ID: 18093835
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.
    Howard TT; Lingerfelt BM; Purnell BL; Scott AE; Price CA; Townes HM; McNulty L; Handl HL; Summerville K; Hudson SJ; Bowen JP; Kiakos K; Hartley JA; Lee M
    Bioorg Med Chem; 2002 Sep; 10(9):2941-52. PubMed ID: 12110316
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and biological evaluation of prodrugs based on the natural antibiotic duocarmycin for use in ADEPT and PMT.
    Tietze LF; Schmuck K; Schuster HJ; Müller M; Schuberth I
    Chemistry; 2011 Feb; 17(6):1922-9. PubMed ID: 21274943
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of cytokine production by hymenialdisine derivatives.
    Sharma V; Lansdell TA; Jin G; Tepe JJ
    J Med Chem; 2004 Jul; 47(14):3700-3. PubMed ID: 15214798
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.