564 related articles for article (PubMed ID: 15584903)
21. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production.
Wilson CA; Doms RW; Lee VM
J Neurosci Res; 2003 Nov; 74(3):361-9. PubMed ID: 14598312
[TBL] [Abstract][Full Text] [Related]
22. The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice.
Asai M; Hattori C; Iwata N; Saido TC; Sasagawa N; Szabó B; Hashimoto Y; Maruyama K; Tanuma S; Kiso Y; Ishiura S
J Neurochem; 2006 Jan; 96(2):533-40. PubMed ID: 16336629
[TBL] [Abstract][Full Text] [Related]
23. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.
Peng Y; Jiang L; Lee DY; Schachter SC; Ma Z; Lemere CA
J Neurosci Res; 2006 Sep; 84(4):903-11. PubMed ID: 16862548
[TBL] [Abstract][Full Text] [Related]
24. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease.
Sheng B; Gong K; Niu Y; Liu L; Yan Y; Lu G; Zhang L; Hu M; Zhao N; Zhang X; Tang P; Gong Y
Free Radic Biol Med; 2009 May; 46(10):1362-75. PubMed ID: 19264123
[TBL] [Abstract][Full Text] [Related]
25. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
[TBL] [Abstract][Full Text] [Related]
26. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Jäger S; Leuchtenberger S; Martin A; Czirr E; Wesselowski J; Dieckmann M; Waldron E; Korth C; Koo EH; Heneka M; Weggen S; Pietrzik CU
J Neurochem; 2009 Dec; 111(6):1369-82. PubMed ID: 19804379
[TBL] [Abstract][Full Text] [Related]
27. In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.
Sankaranarayanan S; Price EA; Wu G; Crouthamel MC; Shi XP; Tugusheva K; Tyler KX; Kahana J; Ellis J; Jin L; Steele T; Stachel S; Coburn C; Simon AJ
J Pharmacol Exp Ther; 2008 Mar; 324(3):957-69. PubMed ID: 18156464
[TBL] [Abstract][Full Text] [Related]
28. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
29. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
[TBL] [Abstract][Full Text] [Related]
30. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism.
Araki W; Kume H; Oda A; Tamaoka A; Kametani F
Biochem Biophys Res Commun; 2009 Feb; 380(1):111-4. PubMed ID: 19167357
[TBL] [Abstract][Full Text] [Related]
31. [Recent advances in Alzheimer's disease research--amyloid precursor protein trafficking, processing, and mutations in Alzheimer's disease linked genes].
Fukatsu R; Tsuzuki K; Hayashi Y; Takamaru Y; Sasaki N; Yoshida T; Hatakeyama Y; Fuji N; Takahata N
Hokkaido Igaku Zasshi; 1997 Jan; 72(1):3-11. PubMed ID: 9086357
[TBL] [Abstract][Full Text] [Related]
32. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
Terro F; Czech C; Esclaire F; Elyaman W; Yardin C; Baclet MC; Touchet N; Tremp G; Pradier L; Hugon J
J Neurosci Res; 2002 Aug; 69(4):530-9. PubMed ID: 12210846
[TBL] [Abstract][Full Text] [Related]
33. LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
Majercak J; Ray WJ; Espeseth A; Simon A; Shi XP; Wolffe C; Getty K; Marine S; Stec E; Ferrer M; Strulovici B; Bartz S; Gates A; Xu M; Huang Q; Ma L; Shughrue P; Burchard J; Colussi D; Pietrak B; Kahana J; Beher D; Rosahl T; Shearman M; Hazuda D; Sachs AB; Koblan KS; Seabrook GR; Stone DJ
Proc Natl Acad Sci U S A; 2006 Nov; 103(47):17967-72. PubMed ID: 17098871
[TBL] [Abstract][Full Text] [Related]
34. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
[TBL] [Abstract][Full Text] [Related]
35. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.
Funamoto S; Morishima-Kawashima M; Tanimura Y; Hirotani N; Saido TC; Ihara Y
Biochemistry; 2004 Oct; 43(42):13532-40. PubMed ID: 15491160
[TBL] [Abstract][Full Text] [Related]
36. Mutations in the transmembrane domain of APP altering gamma-secretase specificity.
Lichtenthaler SF; Ida N; Multhaup G; Masters CL; Beyreuther K
Biochemistry; 1997 Dec; 36(49):15396-403. PubMed ID: 9398269
[TBL] [Abstract][Full Text] [Related]
37. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
Na CH; Jeon SH; Zhang G; Olson GL; Chae CB
J Neurochem; 2007 Jun; 101(6):1583-95. PubMed ID: 17542811
[TBL] [Abstract][Full Text] [Related]
38. Intracellular generation of amyloid beta-protein from amyloid beta-protein precursor fragment by direct cleavage with beta- and gamma-secretase.
Iizuka T; Shoji M; Kawarabayashi T; Sato M; Kobayashi T; Tada N; Kasai K; Matsubara E; Watanabe M; Tomidokoro Y; Hirai S
Biochem Biophys Res Commun; 1996 Jan; 218(1):238-42. PubMed ID: 8573139
[TBL] [Abstract][Full Text] [Related]
39. Intracellular copper deficiency increases amyloid-beta secretion by diverse mechanisms.
Cater MA; McInnes KT; Li QX; Volitakis I; La Fontaine S; Mercer JF; Bush AI
Biochem J; 2008 May; 412(1):141-52. PubMed ID: 18248325
[TBL] [Abstract][Full Text] [Related]
40. Modulation of neutrophil apoptosis by beta-amyloid proteins.
Park HY; Park JI; Baek DW; Lee SY; Lee MJ; Jin JO; Kim JW; Hong YS; Lee YH; Kwak JY
Int Immunopharmacol; 2006 Jul; 6(7):1061-9. PubMed ID: 16714209
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]