BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

196 related articles for article (PubMed ID: 15591246)

  • 21. Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor.
    Armstrong N; Jasti J; Beich-Frandsen M; Gouaux E
    Cell; 2006 Oct; 127(1):85-97. PubMed ID: 17018279
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling.
    Chen PE; Geballe MT; Stansfeld PJ; Johnston AR; Yuan H; Jacob AL; Snyder JP; Traynelis SF; Wyllie DJ
    Mol Pharmacol; 2005 May; 67(5):1470-84. PubMed ID: 15703381
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.
    Inanobe A; Furukawa H; Gouaux E
    Neuron; 2005 Jul; 47(1):71-84. PubMed ID: 15996549
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Disruption of agonist and ligand activity in an AMPA glutamate receptor splice-variable domain deletion mutant.
    Johnson WD; Parandaman V; Onaivi ES; Taylor RE; Akinshola BE
    Brain Res; 2008 Jul; 1222():18-30. PubMed ID: 18585685
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Molecular determinants of ligand discrimination in the glutamate-binding pocket of the NMDA receptor.
    Laube B; Schemm R; Betz H
    Neuropharmacology; 2004 Dec; 47(7):994-1007. PubMed ID: 15555634
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Model structures of the N-methyl-D-aspartate receptor subunit NR1 explain the molecular recognition of agonist and antagonist ligands.
    Moretti L; Pentikäinen OT; Settimo L; Johnson MS
    J Struct Biol; 2004 Mar; 145(3):205-15. PubMed ID: 14960371
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Structure of a glutamate-receptor ligand-binding core in complex with kainate.
    Armstrong N; Sun Y; Chen GQ; Gouaux E
    Nature; 1998 Oct; 395(6705):913-7. PubMed ID: 9804426
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Subtype selectivity and flexibility of ionotropic glutamate receptors upon antagonist ligand binding.
    Pentikäinen U; Settimo L; Johnson MS; Pentikäinen OT
    Org Biomol Chem; 2006 Mar; 4(6):1058-70. PubMed ID: 16525550
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists.
    Fay AM; Corbeil CR; Brown P; Moitessier N; Bowie D
    Mol Pharmacol; 2009 May; 75(5):1096-107. PubMed ID: 19225180
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct.
    Chen GQ; Sun Y; Jin R; Gouaux E
    Protein Sci; 1998 Dec; 7(12):2623-30. PubMed ID: 9865957
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Stereochemistry of glutamate receptor agonist efficacy: engineering a dual-specificity AMPA/kainate receptor.
    Madden DR; Cheng Q; Thiran S; Rajan S; Rigo F; Keinänen K; Reinelt S; Zimmermann H; Jayaraman V
    Biochemistry; 2004 Dec; 43(50):15838-44. PubMed ID: 15595838
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites.
    Kaae BH; Harpsøe K; Kastrup JS; Sanz AC; Pickering DS; Metzler B; Clausen RP; Gajhede M; Sauerberg P; Liljefors T; Madsen U
    Chem Biol; 2007 Nov; 14(11):1294-303. PubMed ID: 18022568
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Kainate induces various domain closures in AMPA and kainate receptors.
    Venskutonytė R; Frydenvang K; Hald H; Rabassa AC; Gajhede M; Ahring PK; Kastrup JS
    Neurochem Int; 2012 Sep; 61(4):536-45. PubMed ID: 22425692
    [TBL] [Abstract][Full Text] [Related]  

  • 34. A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure.
    Szymańska E; Frydenvang K; Contreras-Sanz A; Pickering DS; Frola E; Serafimoska Z; Nielsen B; Kastrup JS; Johansen TN
    J Med Chem; 2011 Oct; 54(20):7289-98. PubMed ID: 21923187
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4.
    Kasper C; Frydenvang K; Naur P; Gajhede M; Pickering DS; Kastrup JS
    FEBS Lett; 2008 Dec; 582(29):4089-94. PubMed ID: 19022251
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes.
    Armstrong N; Mayer M; Gouaux E
    Proc Natl Acad Sci U S A; 2003 May; 100(10):5736-41. PubMed ID: 12730367
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists.
    Gill A; Birdsey-Benson A; Jones BL; Henderson LP; Madden DR
    Biochemistry; 2008 Dec; 47(52):13831-41. PubMed ID: 19102704
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.
    Frølund B; Greenwood JR; Holm MM; Egebjerg J; Madsen U; Nielsen B; Bräuner-Osborne H; Stensbøl TB; Krogsgaard-Larsen P
    Bioorg Med Chem; 2005 Sep; 13(18):5391-8. PubMed ID: 16043357
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Selective agonist binding of (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) and 2S-(2alpha,3beta,4beta)-2-carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid (kainate) receptors: a molecular modeling study.
    Pentikäinen OT; Settimo L; Keinänen K; Johnson MS
    Biochem Pharmacol; 2003 Dec; 66(12):2413-25. PubMed ID: 14637199
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Binding of 5'-GMP to the GluR2 AMPA receptor: insight from targeted molecular dynamics simulations.
    Mendieta J; Gago F; Ramírez G
    Biochemistry; 2005 Nov; 44(44):14470-6. PubMed ID: 16262247
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 10.