80 related articles for article (PubMed ID: 15603955)
1. (S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.
L'Heureux A; Martel A; He H; Chen J; Sun LQ; Starrett JE; Natale J; Dworetzky SI; Knox RJ; Harden DG; Weaver D; Thompson MW; Wu YJ
Bioorg Med Chem Lett; 2005 Jan; 15(2):363-6. PubMed ID: 15603955
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
Wu YJ; Sun LQ; He H; Chen J; Starrett JE; Dextraze P; Daris JP; Boissard CG; Pieschl RL; Gribkoff VK; Natale J; Knox RJ; Harden DG; Thompson MW; Fitzpatrick W; Weaver D; Wu D; Gao Q; Dworetzky SI
Bioorg Med Chem Lett; 2004 Sep; 14(17):4533-7. PubMed ID: 15357987
[TBL] [Abstract][Full Text] [Related]
3. (S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.
Wu YJ; Boissard CG; Chen J; Fitzpatrick W; Gao Q; Gribkoff VK; Harden DG; He H; Knox RJ; Natale J; Pieschl RL; Starrett JE; Sun LQ; Thompson M; Weaver D; Wu D; Dworetzky SI
Bioorg Med Chem Lett; 2004 Apr; 14(8):1991-5. PubMed ID: 15050644
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers.
Wu YJ; He H; Sun LQ; L'Heureux A; Chen J; Dextraze P; Starrett JE; Boissard CG; Gribkoff VK; Natale J; Dworetzky SI
J Med Chem; 2004 May; 47(11):2887-96. PubMed ID: 15139767
[TBL] [Abstract][Full Text] [Related]
5. (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
Wu YJ; Boissard CG; Greco C; Gribkoff VK; Harden DG; He H; L'Heureux A; Kang SH; Kinney GG; Knox RJ; Natale J; Newton AE; Lehtinen-Oboma S; Sinz MW; Sivarao DV; Starrett JE; Sun LQ; Tertyshnikova S; Thompson MW; Weaver D; Wong HS; Zhang L; Dworetzky SI
J Med Chem; 2003 Jul; 46(15):3197-200. PubMed ID: 12852750
[TBL] [Abstract][Full Text] [Related]
6. Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Wu YJ; Conway CM; Sun LQ; Machet F; Chen J; Chen P; He H; Bourin C; Calandra V; Polino JL; Davis CD; Heman K; Gribkoff VK; Boissard CG; Knox RJ; Thompson MW; Fitzpatrick W; Weaver D; Harden DG; Natale J; Dworetzky SI; Starrett JE
Bioorg Med Chem Lett; 2013 Nov; 23(22):6188-91. PubMed ID: 24070783
[TBL] [Abstract][Full Text] [Related]
7. The acrylamide (S)-1 differentially affects Kv7 (KCNQ) potassium channels.
Bentzen BH; Schmitt N; Calloe K; Dalby Brown W; Grunnet M; Olesen SP
Neuropharmacology; 2006 Nov; 51(6):1068-77. PubMed ID: 16904708
[TBL] [Abstract][Full Text] [Related]
8. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.
Wickenden AD; Krajewski JL; London B; Wagoner PK; Wilson WA; Clark S; Roeloffs R; McNaughton-Smith G; Rigdon GC
Mol Pharmacol; 2008 Mar; 73(3):977-86. PubMed ID: 18089837
[TBL] [Abstract][Full Text] [Related]
9. Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition.
Wu YJ; Davis CD; Dworetzky S; Fitzpatrick WC; Harden D; He H; Knox RJ; Newton AE; Philip T; Polson C; Sivarao DV; Sun LQ; Tertyshnikova S; Weaver D; Yeola S; Zoeckler M; Sinz MW
J Med Chem; 2003 Aug; 46(18):3778-81. PubMed ID: 12930139
[TBL] [Abstract][Full Text] [Related]
10. The synthesis and structure-activity relationships of 3-amino-4-benzylquinolin-2-ones; discovery of novel KCNQ2 channel openers.
Hewawasam P; Chen N; Ding M; Natale JT; Boissard CG; Yeola S; Gribkoff VK; Starrett J; Dworetzky SI
Bioorg Med Chem Lett; 2004 Apr; 14(7):1615-8. PubMed ID: 15026035
[TBL] [Abstract][Full Text] [Related]
11. Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents.
Tarleton M; Dyson L; Gilbert J; Sakoff JA; McCluskey A
Bioorg Med Chem; 2013 Jan; 21(1):333-47. PubMed ID: 23176751
[TBL] [Abstract][Full Text] [Related]
12. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models.
Roeloffs R; Wickenden AD; Crean C; Werness S; McNaughton-Smith G; Stables J; McNamara JO; Ghodadra N; Rigdon GC
J Pharmacol Exp Ther; 2008 Sep; 326(3):818-28. PubMed ID: 18577704
[TBL] [Abstract][Full Text] [Related]
13. Electrophysiologic characterization of a novel hERG channel activator.
Su Z; Limberis J; Souers A; Kym P; Mikhail A; Houseman K; Diaz G; Liu X; Martin RL; Cox BF; Gintant GA
Biochem Pharmacol; 2009 Apr; 77(8):1383-90. PubMed ID: 19426677
[TBL] [Abstract][Full Text] [Related]
14. The ethylene bis-dithiocarbamate fungicide Mancozeb activates voltage-gated KCNQ2 potassium channel.
Li P; Zhu J; Kong Q; Jiang B; Wan X; Yue J; Li M; Jiang H; Li J; Gao Z
Toxicol Lett; 2013 Jun; 219(3):211-7. PubMed ID: 23542819
[TBL] [Abstract][Full Text] [Related]
15. Pre- and postsynaptic activation of M-channels by a novel opener dampens neuronal firing and transmitter release.
Peretz A; Sheinin A; Yue C; Degani-Katzav N; Gibor G; Nachman R; Gopin A; Tam E; Shabat D; Yaari Y; Attali B
J Neurophysiol; 2007 Jan; 97(1):283-95. PubMed ID: 17050829
[TBL] [Abstract][Full Text] [Related]
16. The synthesis and biological evaluation of some caffeic acid amide derivatives: E-2-cyano-(3-substituted phenyl)acrylamides.
Zhou W; Li HB; Xia CN; Zheng XM; Hu WX
Bioorg Med Chem Lett; 2009 Apr; 19(7):1861-5. PubMed ID: 19272773
[TBL] [Abstract][Full Text] [Related]
17. N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.
Wang H; Yu N; Song H; Chen D; Zou Y; Deng W; Lye PL; Chang J; Ng M; Sun ET; Sangthongpitag K; Wang X; Wu X; Khng HH; Fang L; Goh SK; Ong WC; Bonday Z; Stünkel W; Poulsen A; Entzeroth M
Bioorg Med Chem Lett; 2009 Mar; 19(5):1403-8. PubMed ID: 19181524
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.
Hill TA; Gordon CP; McGeachie AB; Venn-Brown B; Odell LR; Chau N; Quan A; Mariana A; Sakoff JA; Chircop M; Robinson PJ; McCluskey A
J Med Chem; 2009 Jun; 52(12):3762-73. PubMed ID: 19459681
[TBL] [Abstract][Full Text] [Related]
19. 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD-307243) causes instantaneous current through human ether-a-go-go-related gene potassium channels.
Gordon E; Lozinskaya IM; Lin Z; Semus SF; Blaney FE; Willette RN; Xu X
Mol Pharmacol; 2008 Mar; 73(3):639-51. PubMed ID: 18042732
[TBL] [Abstract][Full Text] [Related]
20. Kv7/KCNQ/M and HCN/h, but not KCa2/SK channels, contribute to the somatic medium after-hyperpolarization and excitability control in CA1 hippocampal pyramidal cells.
Gu N; Vervaeke K; Hu H; Storm JF
J Physiol; 2005 Aug; 566(Pt 3):689-715. PubMed ID: 15890705
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
