169 related articles for article (PubMed ID: 15603957)
1. A novel series of potent gamma-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core.
Lewis SJ; Smith AL; Neduvelil JG; Stevenson GI; Lindon MJ; Jones AB; Shearman MS; Beher D; Clarke E; Best JD; Peachey JE; Harrison T; Castro JL
Bioorg Med Chem Lett; 2005 Jan; 15(2):373-8. PubMed ID: 15603957
[TBL] [Abstract][Full Text] [Related]
2. Cyclic sulfamide gamma-secretase inhibitors.
Sparey T; Beher D; Best J; Biba M; Castro JL; Clarke E; Hannam J; Harrison T; Lewis H; Madin A; Shearman M; Sohal B; Tsou N; Welch C; Wrigley J
Bioorg Med Chem Lett; 2005 Oct; 15(19):4212-6. PubMed ID: 16054361
[TBL] [Abstract][Full Text] [Related]
3. 2,3-Benzodiazepin-1,4-diones as peptidomimetic inhibitors of gamma-secretase.
Prasad CV; Vig S; Smith DW; Gao Q; Polson CT; Corsa JA; Guss VL; Loo A; Barten DM; Zheng M; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2004 Jul; 14(13):3535-8. PubMed ID: 15177468
[TBL] [Abstract][Full Text] [Related]
4. Hydroxytriamides as potent gamma-secretase inhibitors.
Prasad CV; Wallace OB; Noonan JW; Sloan CP; Lau W; Vig S; Parker MF; Smith DW; Hansel SB; Polson CT; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2004 Apr; 14(8):1917-21. PubMed ID: 15050627
[TBL] [Abstract][Full Text] [Related]
5. 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
Shaw D; Best J; Dinnell K; Nadin A; Shearman M; Pattison C; Peachey J; Reilly M; Williams B; Wrigley J; Harrison T
Bioorg Med Chem Lett; 2006 Jun; 16(11):3073-7. PubMed ID: 16617016
[TBL] [Abstract][Full Text] [Related]
6. Molecular-modeling based design, synthesis, and activity of substituted piperidines as gamma-secretase inhibitors.
Gundersen E; Fan K; Haas K; Huryn D; Steven Jacobsen J; Kreft A; Martone R; Mayer S; Sonnenberg-Reines J; Sun SC; Zhou H
Bioorg Med Chem Lett; 2005 Apr; 15(7):1891-4. PubMed ID: 15780628
[TBL] [Abstract][Full Text] [Related]
7. Secretase inhibitors for Alzheimer's disease: challenges of a promiscuous protease.
Pollack SJ; Lewis H
Curr Opin Investig Drugs; 2005 Jan; 6(1):35-47. PubMed ID: 15675602
[TBL] [Abstract][Full Text] [Related]
8. Conformationally biased P3 amide replacements of beta-secretase inhibitors.
Stachel SJ; Coburn CA; Steele TG; Crouthamel MC; Pietrak BL; Lai MT; Holloway MK; Munshi SK; Graham SL; Vacca JP
Bioorg Med Chem Lett; 2006 Feb; 16(3):641-4. PubMed ID: 16263281
[TBL] [Abstract][Full Text] [Related]
9. Novel orally bioavailable gamma-secretase inhibitors with excellent in vivo activity.
Keown LE; Collins I; Cooper LC; Harrison T; Madin A; Mistry J; Reilly M; Shaimi M; Welch CJ; Clarke EE; Lewis HD; Wrigley JD; Best JD; Murray F; Shearman MS
J Med Chem; 2009 Jun; 52(11):3441-4. PubMed ID: 19432431
[TBL] [Abstract][Full Text] [Related]
10. Nitrogen-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bergstrom CP; Sloan CP; Wang HH; Parker MF; Smith DW; Zheng M; Hansel SB; Polson CT; Barber LE; Bursuker I; Guss VL; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2008 Jan; 18(1):175-8. PubMed ID: 18023581
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationship of a novel series of heterocyclic sulfonamide gamma-secretase inhibitors.
Pu J; Kreft AF; Aschmies SH; Atchison KP; Berkowitz J; Caggiano TJ; Chlenov M; Diamantidis G; Harrison BL; Hu Y; Huryn D; Steven Jacobsen J; Jin M; Lipinski K; Lu P; Martone RL; Morris K; Sonnenberg-Reines J; Riddell DR; Sabalski J; Sun SC; Wagner E; Wang Y; Xu Z; Zhou H; Resnick L
Bioorg Med Chem; 2009 Jul; 17(13):4708-17. PubMed ID: 19443228
[TBL] [Abstract][Full Text] [Related]
12. 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
Jelley RA; Elliott J; Gibson KR; Harrison T; Beher D; Clarke EE; Lewis HD; Shearman M; Wrigley JD
Bioorg Med Chem Lett; 2006 Jul; 16(14):3839-42. PubMed ID: 16682202
[TBL] [Abstract][Full Text] [Related]
13. Recent advances in the development of gamma-secretase inhibitors.
Josien H
Curr Opin Drug Discov Devel; 2002 Jul; 5(4):513-25. PubMed ID: 12197309
[TBL] [Abstract][Full Text] [Related]
14. Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide].
Best JD; Jay MT; Otu F; Ma J; Nadin A; Ellis S; Lewis HD; Pattison C; Reilly M; Harrison T; Shearman MS; Williamson TL; Atack JR
J Pharmacol Exp Ther; 2005 May; 313(2):902-8. PubMed ID: 15743924
[TBL] [Abstract][Full Text] [Related]
15. Discovery of amide and heteroaryl isosteres as carbamate replacements in a series of orally active gamma-secretase inhibitors.
McBriar MD; Clader JW; Chu I; Del Vecchio RA; Favreau L; Greenlee WJ; Hyde LA; Nomeir AA; Parker EM; Pissarnitski DA; Song L; Zhang L; Zhao Z
Bioorg Med Chem Lett; 2008 Jan; 18(1):215-9. PubMed ID: 17988864
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase.
Hom RK; Gailunas AF; Mamo S; Fang LY; Tung JS; Walker DE; Davis D; Thorsett ED; Jewett NE; Moon JB; John V
J Med Chem; 2004 Jan; 47(1):158-64. PubMed ID: 14695829
[TBL] [Abstract][Full Text] [Related]
17. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
Churcher I; Beher D; Best JD; Castro JL; Clarke EE; Gentry A; Harrison T; Hitzel L; Kay E; Kerrad S; Lewis HD; Morentin-Gutierrez P; Mortishire-Smith R; Oakley PJ; Reilly M; Shaw DE; Shearman MS; Teall MR; Williams S; Wrigley JD
Bioorg Med Chem Lett; 2006 Jan; 16(2):280-4. PubMed ID: 16275079
[TBL] [Abstract][Full Text] [Related]
18. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Ghosh AK; Devasamudram T; Hong L; DeZutter C; Xu X; Weerasena V; Koelsch G; Bilcer G; Tang J
Bioorg Med Chem Lett; 2005 Jan; 15(1):15-20. PubMed ID: 15582402
[TBL] [Abstract][Full Text] [Related]
19. Carbamate-appended N-alkylsulfonamides as inhibitors of gamma-secretase.
Bergstrom CP; Sloan CP; Lau WY; Smith DW; Zheng M; Hansel SB; Polson CT; Corsa JA; Barten DM; Felsenstein KM; Roberts SB
Bioorg Med Chem Lett; 2008 Jan; 18(2):464-8. PubMed ID: 18178084
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
Lindsley SR; Moore KP; Rajapakse HA; Selnick HG; Young MB; Zhu H; Munshi S; Kuo L; McGaughey GB; Colussi D; Crouthamel MC; Lai MT; Pietrak B; Price EA; Sankaranarayanan S; Simon AJ; Seabrook GR; Hazuda DJ; Pudvah NT; Hochman JH; Graham SL; Vacca JP; Nantermet PG
Bioorg Med Chem Lett; 2007 Jul; 17(14):4057-61. PubMed ID: 17482814
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
