BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

141 related articles for article (PubMed ID: 15604516)

  • 1. Dual-action hypoglycemic and hypocholesterolemic agents that inhibit glycogen phosphorylase and lanosterol demethylase.
    Harwood HJ; Petras SF; Hoover DJ; Mankowski DC; Soliman VF; Sugarman ED; Hulin B; Kwon Y; Gibbs EM; Mayne JT; Treadway JL
    J Lipid Res; 2005 Mar; 46(3):547-63. PubMed ID: 15604516
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).
    Korosec T; Acimovic J; Seliskar M; Kocjan D; Tacer KF; Rozman D; Urleb U
    Bioorg Med Chem; 2008 Jan; 16(1):209-21. PubMed ID: 17964172
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.
    Martin WH; Hoover DJ; Armento SJ; Stock IA; McPherson RK; Danley DE; Stevenson RW; Barrett EJ; Treadway JL
    Proc Natl Acad Sci U S A; 1998 Feb; 95(4):1776-81. PubMed ID: 9465093
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
    Walker KA; Kertesz DJ; Rotstein DM; Swinney DC; Berry PW; So OY; Webb AS; Watson DM; Mak AY; Burton PM
    J Med Chem; 1993 Jul; 36(15):2235-7. PubMed ID: 8340925
    [No Abstract]   [Full Text] [Related]  

  • 5. Lanosterol analogs: dual-action inhibitors of cholesterol biosynthesis.
    Frye LL; Leonard DA
    Crit Rev Biochem Mol Biol; 1999; 34(2):123-40. PubMed ID: 10333389
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors.
    Miao GX; Wang YD; Yan ZW; Zhang LY
    Bioorg Med Chem Lett; 2020 Jul; 30(14):127117. PubMed ID: 32527535
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Pharmacokinetics and anti-hyperglycaemic efficacy of a novel inhibitor of glycogen phosphorylase, 1,4-dideoxy-1,4-imino-d- arabinitol, in glucagon-challenged rats and dogs and in diabetic ob/ob mice.
    Mackay P; Ynddal L; Andersen JV; McCormack JG
    Diabetes Obes Metab; 2003 Nov; 5(6):397-407. PubMed ID: 14617225
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
    Swinney DC; So OY; Watson DM; Berry PW; Webb AS; Kertesz DJ; Shelton EJ; Burton PM; Walker KA
    Biochemistry; 1994 Apr; 33(15):4702-13. PubMed ID: 8161528
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity.
    Burton PM; Swinney DC; Heller R; Dunlap B; Chiou M; Malonzo E; Haller J; Walker KA; Salari A; Murakami S
    Biochem Pharmacol; 1995 Aug; 50(4):529-44. PubMed ID: 7646560
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Effect of 26-oxygenosterols from Ganoderma lucidum and their activity as cholesterol synthesis inhibitors.
    Hajjaj H; Macé C; Roberts M; Niederberger P; Fay LB
    Appl Environ Microbiol; 2005 Jul; 71(7):3653-8. PubMed ID: 16000773
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The effect of glucose on the potency of two distinct glycogen phosphorylase inhibitors.
    Andersen B; Westergaard N
    Biochem J; 2002 Oct; 367(Pt 2):443-50. PubMed ID: 12099891
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.
    Tuck SF; Patel H; Safi E; Robinson CH
    J Lipid Res; 1991 Jun; 32(6):893-902. PubMed ID: 1940622
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors.
    Onda K; Shiraki R; Ogiyama T; Yokoyama K; Momose K; Katayama N; Orita M; Yamaguchi T; Furutani M; Hamada N; Takeuchi M; Okada M; Ohta M; Tsukamoto S
    Bioorg Med Chem; 2008 Dec; 16(23):10001-12. PubMed ID: 18952447
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Indole-2-carboxamide inhibitors of human liver glycogen phosphorylase.
    Hoover DJ; Lefkowitz-Snow S; Burgess-Henry JL; Martin WH; Armento SJ; Stock IA; McPherson RK; Genereux PE; Gibbs EM; Treadway JL
    J Med Chem; 1998 Jul; 41(16):2934-8. PubMed ID: 9685232
    [No Abstract]   [Full Text] [Related]  

  • 15. Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen.
    Cho SY; Kim JH; Paik YK
    Mol Cells; 1998 Apr; 8(2):233-9. PubMed ID: 9638657
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent.
    Lee EY; Lim DM; Yoo SE; Kim DK; Paik YK
    Biochem Pharmacol; 1999 Mar; 57(5):579-82. PubMed ID: 9952322
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.
    Ekins S; Mankowski DC; Hoover DJ; Lawton MP; Treadway JL; Harwood HJ
    Drug Metab Dispos; 2007 Mar; 35(3):493-500. PubMed ID: 17194716
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition.
    Goyard D; Kónya B; Chajistamatiou AS; Chrysina ED; Leroy J; Balzarin S; Tournier M; Tousch D; Petit P; Duret C; Maurel P; Somsák L; Docsa T; Gergely P; Praly JP; Azay-Milhau J; Vidal S
    Eur J Med Chem; 2016 Jan; 108():444-454. PubMed ID: 26708111
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Silencing of mouse hepatic lanosterol 14-alpha demethylase down-regulated plasma low-density lipoprotein cholesterol levels by short-term treatment of siRNA.
    Xu B; Wang C; Yang J; Mao G; Zhang C; Liu D; Tai P; Zhou B; Xia G; Zhang M
    Biol Pharm Bull; 2008 Jun; 31(6):1182-91. PubMed ID: 18520052
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.
    Trzaskos JM; Magolda RL; Favata MF; Fischer RT; Johnson PR; Chen HW; Ko SS; Leonard DA; Gaylor JL
    J Biol Chem; 1993 Oct; 268(30):22591-9. PubMed ID: 7693673
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.