234 related articles for article (PubMed ID: 15610846)
1. Engineered biosynthesis of geldanamycin analogs for Hsp90 inhibition.
Patel K; Piagentini M; Rascher A; Tian ZQ; Buchanan GO; Regentin R; Hu Z; Hutchinson CR; McDaniel R
Chem Biol; 2004 Dec; 11(12):1625-33. PubMed ID: 15610846
[TBL] [Abstract][Full Text] [Related]
2. Rational biosynthetic engineering for optimization of geldanamycin analogues.
Kim W; Lee D; Hong SS; Na Z; Shin JC; Roh SH; Wu CZ; Choi O; Lee K; Shen YM; Paik SG; Lee JJ; Hong YS
Chembiochem; 2009 May; 10(7):1243-51. PubMed ID: 19308924
[TBL] [Abstract][Full Text] [Related]
3. Production of 8-demethylgeldanamycin and 4,5-epoxy-8-demethylgeldanamycin from a recombinant strain of Streptomyces hygroscopicus.
Buchanan GO; Regentin R; Piagentini M; Rascher A; McDaniel R; Galazzo JL; Licari PJ
J Nat Prod; 2005 Apr; 68(4):607-10. PubMed ID: 15844961
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.
Tian ZQ; Liu Y; Zhang D; Wang Z; Dong SD; Carreras CW; Zhou Y; Rastelli G; Santi DV; Myles DC
Bioorg Med Chem; 2004 Oct; 12(20):5317-29. PubMed ID: 15388159
[TBL] [Abstract][Full Text] [Related]
5. New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus.
Wu CZ; Moon AN; Jang JH; Lee D; Kang SY; Park JT; Ahn JS; Hwang BY; Kim YH; Lee HS; Hong YS
J Antibiot (Tokyo); 2011 Jun; 64(6):461-3. PubMed ID: 21448187
[No Abstract] [Full Text] [Related]
6. Characterization of tailoring genes involved in the modification of geldanamycin polyketide in Streptomyces hygroscopicus JCM4427.
Shin JC; Na Z; Lee DH; Kim WC; Lee K; Shen YM; Paik SG; Hong YS; Lee JJ
J Microbiol Biotechnol; 2008 Jun; 18(6):1101-8. PubMed ID: 18600054
[TBL] [Abstract][Full Text] [Related]
7. Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Smith V; Sausville EA; Camalier RF; Fiebig HH; Burger AM
Cancer Chemother Pharmacol; 2005 Aug; 56(2):126-37. PubMed ID: 15841378
[TBL] [Abstract][Full Text] [Related]
8. Inactivation of the carbamoyltransferase gene refines post-polyketide synthase modification steps in the biosynthesis of the antitumor agent geldanamycin.
Hong YS; Lee D; Kim W; Jeong JK; Kim CG; Sohng JK; Lee JH; Paik SG; Lee JJ
J Am Chem Soc; 2004 Sep; 126(36):11142-3. PubMed ID: 15355082
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.
Lee K; Ryu JS; Jin Y; Kim W; Kaur N; Chung SJ; Jeon YJ; Park JT; Bang JS; Lee HS; Kim TY; Lee JJ; Hong YS
Org Biomol Chem; 2008 Jan; 6(2):340-8. PubMed ID: 18175003
[TBL] [Abstract][Full Text] [Related]
10. Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
Le Brazidec JY; Kamal A; Busch D; Thao L; Zhang L; Timony G; Grecko R; Trent K; Lough R; Salazar T; Khan S; Burrows F; Boehm MF
J Med Chem; 2004 Jul; 47(15):3865-73. PubMed ID: 15239664
[TBL] [Abstract][Full Text] [Related]
11. Potent cytotoxic C-11 modified geldanamycin analogues.
Tian ZQ; Wang Z; MacMillan KS; Zhou Y; Carreras CW; Mueller T; Myles DC; Liu Y
J Med Chem; 2009 May; 52(10):3265-73. PubMed ID: 19405528
[TBL] [Abstract][Full Text] [Related]
12. Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.
Onodera H; Kaneko M; Takahashi Y; Uochi Y; Funahashi J; Nakashima T; Soga S; Suzuki M; Ikeda S; Yamashita Y; Rahayu ES; Kanda Y; Ichimura M
Bioorg Med Chem Lett; 2008 Mar; 18(5):1588-91. PubMed ID: 18243703
[TBL] [Abstract][Full Text] [Related]
13. Dihydroquinone ansamycins: toward resolving the conflict between low in vitro affinity and high cellular potency of geldanamycin derivatives.
Maroney AC; Marugan JJ; Mezzasalma TM; Barnakov AN; Garrabrant TA; Weaner LE; Jones WJ; Barnakova LA; Koblish HK; Todd MJ; Masucci JA; Deckman IC; Galemmo RA; Johnson DL
Biochemistry; 2006 May; 45(17):5678-85. PubMed ID: 16634649
[TBL] [Abstract][Full Text] [Related]
14. Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
Schwock J; Pham NA; Cao MP; Hedley DW
Cancer Chemother Pharmacol; 2008 Apr; 61(4):669-81. PubMed ID: 17579866
[TBL] [Abstract][Full Text] [Related]
15. Inactivation of putative PKS genes can double geldanamycin yield in Streptomyces hygroscopicus 17997.
Li YH; Li M; He WQ; Wang YG; Shao RG
Genet Mol Res; 2013 Jun; 12(2):2076-85. PubMed ID: 23913387
[TBL] [Abstract][Full Text] [Related]
16. [Establishment of gene transduction system in geldanamycin producer - Streptomyces hygroscopicus 17997 and its application for gene disruption experiment].
Gao HY; Wang YG; Gao QJ; Shang GD; Sun GZ; Yang Y
Sheng Wu Gong Cheng Xue Bao; 2003 Jul; 19(4):407-11. PubMed ID: 15969055
[TBL] [Abstract][Full Text] [Related]
17. [Heat shock protein 90: novel target for cancer therapy].
Chen Y; Ding J
Ai Zheng; 2004 Aug; 23(8):968-74. PubMed ID: 15301726
[TBL] [Abstract][Full Text] [Related]
18. New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.
Hermane J; Bułyszko I; Eichner S; Sasse F; Collisi W; Poso A; Schax E; Walter JG; Scheper T; Kock K; Herrmann C; Aliuos P; Reuter G; Zeilinger C; Kirschning A
Chembiochem; 2015 Jan; 16(2):302-11. PubMed ID: 25572106
[TBL] [Abstract][Full Text] [Related]
19. Structure-based design of 7-carbamate analogs of geldanamycin.
Rastelli G; Tian ZQ; Wang Z; Myles D; Liu Y
Bioorg Med Chem Lett; 2005 Nov; 15(22):5016-21. PubMed ID: 16165354
[TBL] [Abstract][Full Text] [Related]
20. Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.
Sydor JR; Normant E; Pien CS; Porter JR; Ge J; Grenier L; Pak RH; Ali JA; Dembski MS; Hudak J; Patterson J; Penders C; Pink M; Read MA; Sang J; Woodward C; Zhang Y; Grayzel DS; Wright J; Barrett JA; Palombella VJ; Adams J; Tong JK
Proc Natl Acad Sci U S A; 2006 Nov; 103(46):17408-13. PubMed ID: 17090671
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
