These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 15613471)

  • 1. Functional overexpression of gamma-secretase reveals protease-independent trafficking functions and a critical role of lipids for protease activity.
    Wrigley JD; Schurov I; Nunn EJ; Martin AC; Clarke EE; Ellis S; Bonnert TP; Shearman MS; Beher D
    J Biol Chem; 2005 Apr; 280(13):12523-35. PubMed ID: 15613471
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway.
    Kim SH; Yin YI; Li YM; Sisodia SS
    J Biol Chem; 2004 Nov; 279(47):48615-9. PubMed ID: 15456788
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
    Cervantes S; Saura CA; Pomares E; Gonzàlez-Duarte R; Marfany G
    J Biol Chem; 2004 Aug; 279(35):36519-29. PubMed ID: 15220354
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Localization of presenilin-nicastrin complexes and gamma-secretase activity to the trans-Golgi network.
    Siman R; Velji J
    J Neurochem; 2003 Mar; 84(5):1143-53. PubMed ID: 12603837
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Presenilins and gamma-secretase inhibitors affect intracellular trafficking and cell surface localization of the gamma-secretase complex components.
    Wang H; Luo WJ; Zhang YW; Li YM; Thinakaran G; Greengard P; Xu H
    J Biol Chem; 2004 Sep; 279(39):40560-6. PubMed ID: 15247291
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding.
    Wrigley JD; Nunn EJ; Nyabi O; Clarke EE; Hunt P; Nadin A; De Strooper B; Shearman MS; Beher D
    J Neurochem; 2004 Sep; 90(6):1312-20. PubMed ID: 15341515
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
    Chyung JH; Raper DM; Selkoe DJ
    J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
    Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
    J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
    [TBL] [Abstract][Full Text] [Related]  

  • 9. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation.
    Herreman A; Van Gassen G; Bentahir M; Nyabi O; Craessaerts K; Mueller U; Annaert W; De Strooper B
    J Cell Sci; 2003 Mar; 116(Pt 6):1127-36. PubMed ID: 12584255
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Gamma-secretase complex assembly within the early secretory pathway.
    Capell A; Beher D; Prokop S; Steiner H; Kaether C; Shearman MS; Haass C
    J Biol Chem; 2005 Feb; 280(8):6471-8. PubMed ID: 15591316
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
    Li T; Ma G; Cai H; Price DL; Wong PC
    J Neurosci; 2003 Apr; 23(8):3272-7. PubMed ID: 12716934
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate.
    Esler WP; Kimberly WT; Ostaszewski BL; Ye W; Diehl TS; Selkoe DJ; Wolfe MS
    Proc Natl Acad Sci U S A; 2002 Mar; 99(5):2720-5. PubMed ID: 11867728
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.
    Evin G; Canterford LD; Hoke DE; Sharples RA; Culvenor JG; Masters CL
    Biochemistry; 2005 Mar; 44(11):4332-41. PubMed ID: 15766262
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.
    Li J; Fici GJ; Mao CA; Myers RL; Shuang R; Donoho GP; Pauley AM; Himes CS; Qin W; Kola I; Merchant KM; Nye JS
    J Biol Chem; 2003 Aug; 278(35):33445-9. PubMed ID: 12815056
    [TBL] [Abstract][Full Text] [Related]  

  • 15. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
    Gu Y; Chen F; Sanjo N; Kawarai T; Hasegawa H; Duthie M; Li W; Ruan X; Luthra A; Mount HT; Tandon A; Fraser PE; St George-Hyslop P
    J Biol Chem; 2003 Feb; 278(9):7374-80. PubMed ID: 12471034
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
    Zhou S; Zhou H; Walian PJ; Jap BK
    Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates.
    Baulac S; LaVoie MJ; Kimberly WT; Strahle J; Wolfe MS; Selkoe DJ; Xia W
    Neurobiol Dis; 2003 Nov; 14(2):194-204. PubMed ID: 14572442
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.
    Hansson EM; Strömberg K; Bergstedt S; Yu G; Näslund J; Lundkvist J; Lendahl U
    J Neurochem; 2005 Mar; 92(5):1010-20. PubMed ID: 15715652
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.
    Zhang YW; Luo WJ; Wang H; Lin P; Vetrivel KS; Liao F; Li F; Wong PC; Farquhar MG; Thinakaran G; Xu H
    J Biol Chem; 2005 Apr; 280(17):17020-6. PubMed ID: 15711015
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
    Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
    J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.