105 related articles for article (PubMed ID: 1562278)
1. The properties of total adducts and interstrand crosslinks in the DNA of cells treated with CB 1954. Exceptional frequency and stability of the crosslink.
Friedlos F; Quinn J; Knox RJ; Roberts JJ
Biochem Pharmacol; 1992 Mar; 43(6):1249-54. PubMed ID: 1562278
[TBL] [Abstract][Full Text] [Related]
2. A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in Walker carcinoma cells.
Knox RJ; Friedlos F; Jarman M; Roberts JJ
Biochem Pharmacol; 1988 Dec; 37(24):4661-9. PubMed ID: 3202902
[TBL] [Abstract][Full Text] [Related]
3. Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species.
Knox RJ; Friedlos F; Marchbank T; Roberts JJ
Biochem Pharmacol; 1991 Oct; 42(9):1691-7. PubMed ID: 1930294
[TBL] [Abstract][Full Text] [Related]
4. Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) in Walker cells.
Roberts JJ; Marchbank T; Kotsaki-Kovatsi VP; Boland MP; Friedlos F; Knox RJ
Biochem Pharmacol; 1989 Nov; 38(22):4137-43. PubMed ID: 2480794
[TBL] [Abstract][Full Text] [Related]
5. The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).
Knox RJ; Friedlos F; Boland MP
Cancer Metastasis Rev; 1993 Jun; 12(2):195-212. PubMed ID: 8375021
[TBL] [Abstract][Full Text] [Related]
6. Bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by human NAD(P)H quinone oxidoreductase 2: a novel co-substrate-mediated antitumor prodrug therapy.
Knox RJ; Jenkins TC; Hobbs SM; Chen S; Melton RG; Burke PJ
Cancer Res; 2000 Aug; 60(15):4179-86. PubMed ID: 10945627
[TBL] [Abstract][Full Text] [Related]
7. The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide).
Boland MP; Knox RJ; Roberts JJ
Biochem Pharmacol; 1991 Mar 15-Apr 1; 41(6-7):867-75. PubMed ID: 1901207
[TBL] [Abstract][Full Text] [Related]
8. CB 1954 (2,4-dinitro-5-aziridinyl benzamide) becomes a DNA interstrand crosslinking agent in Walker tumour cells.
Roberts JJ; Friedlos F; Knox RJ
Biochem Biophys Res Commun; 1986 Nov; 140(3):1073-8. PubMed ID: 3778483
[TBL] [Abstract][Full Text] [Related]
9. The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2).
Knox RJ; Boland MP; Friedlos F; Coles B; Southan C; Roberts JJ
Biochem Pharmacol; 1988 Dec; 37(24):4671-7. PubMed ID: 3144286
[TBL] [Abstract][Full Text] [Related]
10. Structure-activity study with bioreductive benzoquinone alkylating agents: effects on DT-diaphorase-mediated DNA crosslink and strand break formation in relation to mechanisms of cytotoxicity.
Fourie J; Guziec F; Guziec L; Monterrosa C; Fiterman DJ; Begleiter A
Cancer Chemother Pharmacol; 2004 Mar; 53(3):191-203. PubMed ID: 14614574
[TBL] [Abstract][Full Text] [Related]
11. The bioactivation of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954)--II. A comparison of an Escherichia coli nitroreductase and Walker DT diaphorase.
Knox RJ; Friedlos F; Sherwood RF; Melton RG; Anlezark GM
Biochem Pharmacol; 1992 Dec; 44(12):2297-301. PubMed ID: 1472095
[TBL] [Abstract][Full Text] [Related]
12. Identification, synthesis and properties of 5-(aziridin-1-yl)-2-nitro-4-nitrosobenzamide, a novel DNA crosslinking agent derived from CB1954.
Knox RJ; Friedlos F; Biggs PJ; Flitter WD; Gaskell M; Goddard P; Davies L; Jarman M
Biochem Pharmacol; 1993 Sep; 46(5):797-803. PubMed ID: 8373433
[TBL] [Abstract][Full Text] [Related]
13. Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity.
Friedlos F; Biggs PJ; Abrahamson JA; Knox RJ
Biochem Pharmacol; 1992 Nov; 44(9):1739-43. PubMed ID: 1449531
[TBL] [Abstract][Full Text] [Related]
14. CB 1954: from the Walker tumor to NQO2 and VDEPT.
Knox RJ; Burke PJ; Chen S; Kerr DJ
Curr Pharm Des; 2003; 9(26):2091-104. PubMed ID: 14529407
[TBL] [Abstract][Full Text] [Related]
15. Phthalimide analogs of CB 1954: synthesis and bioactivation.
Mehta LK; Hobbs S; Chen S; Knox RJ; Parrick J
Anticancer Drugs; 1999 Sep; 10(8):777-83. PubMed ID: 10573210
[TBL] [Abstract][Full Text] [Related]
16. The Walker 256 carcinoma: a cell type inherently sensitive only to those difunctional agents that can form DNA interstrand crosslinks.
Knox RJ; Lydall DA; Friedlos F; Basham C; Rawlings CJ; Roberts JJ
Mutat Res; 1991 Nov; 255(3):227-40. PubMed ID: 1719394
[TBL] [Abstract][Full Text] [Related]
17. Bioactivation of dinitrobenzamide mustards by an E. coli B nitroreductase.
Anlezark GM; Melton RG; Sherwood RF; Wilson WR; Denny WA; Palmer BD; Knox RJ; Friedlos F; Williams A
Biochem Pharmacol; 1995 Aug; 50(5):609-18. PubMed ID: 7669063
[TBL] [Abstract][Full Text] [Related]
18. Effect of nitroreduction on the alkylating reactivity and cytotoxicity of the 2,4-dinitrobenzamide-5-aziridine CB 1954 and the corresponding nitrogen mustard SN 23862: distinct mechanisms of bioreductive activation.
Helsby NA; Wheeler SJ; Pruijn FB; Palmer BD; Yang S; Denny WA; Wilson WR
Chem Res Toxicol; 2003 Apr; 16(4):469-78. PubMed ID: 12703963
[TBL] [Abstract][Full Text] [Related]
19. The effect of monofunctional or difunctional platinum adducts and of various other associated DNA damage on the expression of transfected DNA in mammalian cell lines sensitive or resistant to difunctional agents.
Knox RJ; Lydall DA; Friedlos F; Basham C; Roberts JJ
Biochim Biophys Acta; 1987 Apr; 908(3):214-23. PubMed ID: 3567197
[TBL] [Abstract][Full Text] [Related]
20. Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.
Helsby NA; Atwell GJ; Yang S; Palmer BD; Anderson RF; Pullen SM; Ferry DM; Hogg A; Wilson WR; Denny WA
J Med Chem; 2004 Jun; 47(12):3295-307. PubMed ID: 15163209
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
