192 related articles for article (PubMed ID: 15637067)
1. Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus.
Fillebeen C; Rivas-Estilla AM; Bisaillon M; Ponka P; Muckenthaler M; Hentze MW; Koromilas AE; Pantopoulos K
J Biol Chem; 2005 Mar; 280(10):9049-57. PubMed ID: 15637067
[TBL] [Abstract][Full Text] [Related]
2. Interference of HCV replication by cell penetrable human monoclonal scFv specific to NS5B polymerase.
Thueng-in K; Thanongsaksrikul J; Jittavisutthikul S; Seesuay W; Chulanetra M; Sakolvaree Y; Srimanote P; Chaicumpa W
MAbs; 2014; 6(5):1327-39. PubMed ID: 25517317
[TBL] [Abstract][Full Text] [Related]
3. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
Klumpp K; Lévêque V; Le Pogam S; Ma H; Jiang WR; Kang H; Granycome C; Singer M; Laxton C; Hang JQ; Sarma K; Smith DB; Heindl D; Hobbs CJ; Merrett JH; Symons J; Cammack N; Martin JA; Devos R; Nájera I
J Biol Chem; 2006 Feb; 281(7):3793-9. PubMed ID: 16316989
[TBL] [Abstract][Full Text] [Related]
4. The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo.
Lee KJ; Choi J; Ou JH; Lai MM
J Virol; 2004 Apr; 78(7):3797-802. PubMed ID: 15016899
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of hepatitis C virus (HCV) replication by specific RNA aptamers against HCV NS5B RNA replicase.
Lee CH; Lee YJ; Kim JH; Lim JH; Kim JH; Han W; Lee SH; Noh GJ; Lee SW
J Virol; 2013 Jun; 87(12):7064-74. PubMed ID: 23596299
[TBL] [Abstract][Full Text] [Related]
6. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides.
Chan L; Das SK; Reddy TJ; Poisson C; Proulx M; Pereira O; Courchesne M; Roy C; Wang W; Siddiqui A; Yannopoulos CG; Nguyen-Ba N; Labrecque D; Bethell R; Hamel M; Courtemanche-Asselin P; L'Heureux L; David M; Nicolas O; Brunette S; Bilimoria D; Bédard J
Bioorg Med Chem Lett; 2004 Feb; 14(3):793-6. PubMed ID: 14741291
[TBL] [Abstract][Full Text] [Related]
7. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM; Murakami E; Espiritu C; Steuer HM; Niu C; Keilman M; Bao H; Zennou V; Bourne N; Julander JG; Morrey JD; Smee DF; Frick DN; Heck JA; Wang P; Nagarathnam D; Ross BS; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2010 Aug; 54(8):3187-96. PubMed ID: 20516278
[TBL] [Abstract][Full Text] [Related]
8. Selected replicon variants with low-level in vitro resistance to the hepatitis C virus NS5B polymerase inhibitor PSI-6130 lack cross-resistance with R1479.
Ali S; Leveque V; Le Pogam S; Ma H; Philipp F; Inocencio N; Smith M; Alker A; Kang H; Najera I; Klumpp K; Symons J; Cammack N; Jiang WR
Antimicrob Agents Chemother; 2008 Dec; 52(12):4356-69. PubMed ID: 18838588
[TBL] [Abstract][Full Text] [Related]
9. Recent advances in discovery and development of promising therapeutics against hepatitis C virus NS5B RNA-dependent RNA polymerase.
Wu JZ; Yao N; Walker M; Hong Z
Mini Rev Med Chem; 2005 Dec; 5(12):1103-12. PubMed ID: 16375756
[TBL] [Abstract][Full Text] [Related]
10. Silibinin and related compounds are direct inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
Ahmed-Belkacem A; Ahnou N; Barbotte L; Wychowski C; Pallier C; Brillet R; Pohl RT; Pawlotsky JM
Gastroenterology; 2010 Mar; 138(3):1112-22. PubMed ID: 19962982
[TBL] [Abstract][Full Text] [Related]
11. Phosphorylation of hepatitis C virus RNA polymerases ser29 and ser42 by protein kinase C-related kinase 2 regulates viral RNA replication.
Han SH; Kim SJ; Kim EJ; Kim TE; Moon JS; Kim GW; Lee SH; Cho K; Yoo JS; Son WS; Rhee JK; Han SH; Oh JW
J Virol; 2014 Oct; 88(19):11240-52. PubMed ID: 25031343
[TBL] [Abstract][Full Text] [Related]
12. Specific inhibitors of HCV polymerase identified using an NS5B with lower affinity for template/primer substrate.
McKercher G; Beaulieu PL; Lamarre D; LaPlante S; Lefebvre S; Pellerin C; Thauvette L; Kukolj G
Nucleic Acids Res; 2004; 32(2):422-31. PubMed ID: 14739234
[TBL] [Abstract][Full Text] [Related]
13. RacGTPase-activating protein 1 interacts with hepatitis C virus polymerase NS5B to regulate viral replication.
Wu MJ; Ke PY; Horng JT
Biochem Biophys Res Commun; 2014 Nov; 454(1):19-24. PubMed ID: 25305482
[TBL] [Abstract][Full Text] [Related]
14. Molecular mechanism of hepatitis C virus replicon variants with reduced susceptibility to a benzofuran inhibitor, HCV-796.
Howe AY; Cheng H; Johann S; Mullen S; Chunduru SK; Young DC; Bard J; Chopra R; Krishnamurthy G; Mansour T; O'Connell J
Antimicrob Agents Chemother; 2008 Sep; 52(9):3327-38. PubMed ID: 18559648
[TBL] [Abstract][Full Text] [Related]
15. Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.
Jin G; Lee S; Choi M; Son S; Kim GW; Oh JW; Lee C; Lee K
Eur J Med Chem; 2014 Mar; 75():413-25. PubMed ID: 24561671
[TBL] [Abstract][Full Text] [Related]
16. Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.
Cheney IW; Naim S; Lai VC; Dempsey S; Bellows D; Walker MP; Shim JH; Horscroft N; Hong Z; Zhong W
Virology; 2002 Jun; 297(2):298-306. PubMed ID: 12083828
[TBL] [Abstract][Full Text] [Related]
17. Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: tertiary amides.
Chan L; Pereira O; Reddy TJ; Das SK; Poisson C; Courchesne M; Proulx M; Siddiqui A; Yannopoulos CG; Nguyen-Ba N; Roy C; Nasturica D; Moinet C; Bethell R; Hamel M; L'Heureux L; David M; Nicolas O; Courtemanche-Asselin P; Brunette S; Bilimoria D; Bédard J
Bioorg Med Chem Lett; 2004 Feb; 14(3):797-800. PubMed ID: 14741292
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of hepatitis C virus translation and subgenomic replication by siRNAs directed against highly conserved HCV sequence and cellular HCV cofactors.
Korf M; Jarczak D; Beger C; Manns MP; Krüger M
J Hepatol; 2005 Aug; 43(2):225-34. PubMed ID: 15964661
[TBL] [Abstract][Full Text] [Related]
19. Mutagenesis analysis of the rGTP-specific binding site of hepatitis C virus RNA-dependent RNA polymerase.
Cai Z; Yi M; Zhang C; Luo G
J Virol; 2005 Sep; 79(18):11607-17. PubMed ID: 16140738
[TBL] [Abstract][Full Text] [Related]
20. TMC647055, a potent nonnucleoside hepatitis C virus NS5B polymerase inhibitor with cross-genotypic coverage.
Devogelaere B; Berke JM; Vijgen L; Dehertogh P; Fransen E; Cleiren E; van der Helm L; Nyanguile O; Tahri A; Amssoms K; Lenz O; Cummings MD; Clayton RF; Vendeville S; Raboisson P; Simmen KA; Fanning GC; Lin TI
Antimicrob Agents Chemother; 2012 Sep; 56(9):4676-84. PubMed ID: 22710121
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]