These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

125 related articles for article (PubMed ID: 15654896)

  • 1. Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site.
    Tyagi R; Lee YT; Guddat LW; Duggleby RG
    FEBS J; 2005 Jan; 272(2):593-602. PubMed ID: 15654896
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures.
    Leung EW; Guddat LW
    J Mol Biol; 2009 May; 389(1):167-82. PubMed ID: 19362563
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Purified recombinant Escherichia coli ketol-acid reductoisomerase is unsuitable for use in a coupled assay of acetohydroxyacid synthase activity due to an unexpected side reaction.
    Hill CM; Duggleby RG
    Protein Expr Purif; 1999 Feb; 15(1):57-61. PubMed ID: 10024470
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Facile crystallization of Escherichia coli ketol-acid reductoisomerase.
    McCourt JA; Tyagi R; Guddat LW; Biou V; Duggleby RG
    Acta Crystallogr D Biol Crystallogr; 2004 Aug; 60(Pt 8):1432-4. PubMed ID: 15272168
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A loop deletion in the plant acetohydroxy acid isomeroreductase homodimer generates an active monomer with reduced stability and altered magnesium affinity.
    Wessel PM; Biou V; Douce R; Dumas R
    Biochemistry; 1998 Sep; 37(37):12753-60. PubMed ID: 9737852
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Reversal of the nucleotide specificity of ketol acid reductoisomerase by site-directed mutagenesis identifies the NADPH binding site.
    Rane MJ; Calvo KC
    Arch Biochem Biophys; 1997 Feb; 338(1):83-9. PubMed ID: 9015391
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Characterization of the conformational changes of acetohydroxy acid isomeroreductase induced by the binding of Mg2+ ions, NADPH, and a competitive inhibitor.
    Halgand F; Dumas R; Biou V; Andrieu JP; Thomazeau K; Gagnon J; Douce R; Forest E
    Biochemistry; 1999 May; 38(19):6025-34. PubMed ID: 10320328
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Metal Ions Play an Essential Catalytic Role in the Mechanism of Ketol-Acid Reductoisomerase.
    Tadrowski S; Pedroso MM; Sieber V; Larrabee JA; Guddat LW; Schenk G
    Chemistry; 2016 May; 22(22):7427-36. PubMed ID: 27136273
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Evidence for two catalytically different magnesium-binding sites in acetohydroxy acid isomeroreductase by site-directed mutagenesis.
    Dumas R; Butikofer MC; Job D; Douce R
    Biochemistry; 1995 May; 34(18):6026-36. PubMed ID: 7742305
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Probing the sterol binding site of soybean sterol methyltransferase by site-directed mutagenesis: functional analysis of conserved aromatic amino acids in Region 1.
    Nes WD; Sinha A; Jayasimha P; Zhou W; Song Z; Dennis AL
    Arch Biochem Biophys; 2006 Apr; 448(1-2):23-30. PubMed ID: 16271698
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Site-directed mutagenesis of selected residues at the active site of aryl-alcohol oxidase, an H2O2-producing ligninolytic enzyme.
    Ferreira P; Ruiz-Dueñas FJ; Martínez MJ; van Berkel WJ; Martínez AT
    FEBS J; 2006 Nov; 273(21):4878-88. PubMed ID: 16999821
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis, bioactivity, theoretical and molecular docking study of 1-cyano-N-substituted-cyclopropanecarboxamide as ketol-acid reductoisomerase inhibitor.
    Liu XH; Chen PQ; Wang BL; Li YH; Wang SH; Li ZM
    Bioorg Med Chem Lett; 2007 Jul; 17(13):3784-8. PubMed ID: 17512731
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of the beta-carbon processing reactions of the mammalian cytosolic fatty acid synthase: role of the central core.
    Witkowski A; Joshi AK; Smith S
    Biochemistry; 2004 Aug; 43(32):10458-66. PubMed ID: 15301544
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanism of ketol acid reductoisomerase--steady-state analysis and metal ion requirement.
    Chunduru SK; Mrachko GT; Calvo KC
    Biochemistry; 1989 Jan; 28(2):486-93. PubMed ID: 2653423
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle.
    Wong SH; Lonhienne TG; Winzor DJ; Schenk G; Guddat LW
    J Mol Biol; 2012 Dec; 424(3-4):168-79. PubMed ID: 23036858
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Oxalyl hydroxamates as reaction-intermediate analogues for ketol-acid reductoisomerase.
    Aulabaugh A; Schloss JV
    Biochemistry; 1990 Mar; 29(11):2824-30. PubMed ID: 2189496
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The crystal structure of Escherichia coli ketopantoate reductase with NADP+ bound.
    Lobley CM; Ciulli A; Whitney HM; Williams G; Smith AG; Abell C; Blundell TL
    Biochemistry; 2005 Jun; 44(25):8930-9. PubMed ID: 15966718
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structure of Mycobacterium tuberculosis ketol-acid reductoisomerase at 1.0 Å resolution - a potential target for anti-tuberculosis drug discovery.
    Lv Y; Kandale A; Wun SJ; McGeary RP; Williams SJ; Kobe B; Sieber V; Schembri MA; Schenk G; Guddat LW
    FEBS J; 2016 Apr; 283(7):1184-96. PubMed ID: 26876563
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Probing the promiscuous active site of myo-inositol dehydrogenase using synthetic substrates, homology modeling, and active site modification.
    Daniellou R; Zheng H; Langill DM; Sanders DA; Palmer DR
    Biochemistry; 2007 Jun; 46(25):7469-77. PubMed ID: 17539607
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The pH dependence of the kinetic parameters of ketol acid reductoisomerase indicates a proton shuttle mechanism for alkyl migration.
    Mrachko GT; Chunduru SK; Calvo KC
    Arch Biochem Biophys; 1992 May; 294(2):446-53. PubMed ID: 1567200
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.