239 related articles for article (PubMed ID: 15664853)
1. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors.
Lindsley CW; Zhao Z; Leister WH; Robinson RG; Barnett SF; Defeo-Jones D; Jones RE; Hartman GD; Huff JR; Huber HE; Duggan ME
Bioorg Med Chem Lett; 2005 Feb; 15(3):761-4. PubMed ID: 15664853
[TBL] [Abstract][Full Text] [Related]
2. Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors.
Zhao Z; Leister WH; Robinson RG; Barnett SF; Defeo-Jones D; Jones RE; Hartman GD; Huff JR; Huber HE; Duggan ME; Lindsley CW
Bioorg Med Chem Lett; 2005 Feb; 15(4):905-9. PubMed ID: 15686884
[TBL] [Abstract][Full Text] [Related]
3. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors.
Barnett SF; Defeo-Jones D; Fu S; Hancock PJ; Haskell KM; Jones RE; Kahana JA; Kral AM; Leander K; Lee LL; Malinowski J; McAvoy EM; Nahas DD; Robinson RG; Huber HE
Biochem J; 2005 Jan; 385(Pt 2):399-408. PubMed ID: 15456405
[TBL] [Abstract][Full Text] [Related]
4. Development of potent, allosteric dual Akt1 and Akt2 inhibitors with improved physical properties and cell activity.
Zhao Z; Robinson RG; Barnett SF; Defeo-Jones D; Jones RE; Hartman GD; Huber HE; Duggan ME; Lindsley CW
Bioorg Med Chem Lett; 2008 Jan; 18(1):49-53. PubMed ID: 18054229
[TBL] [Abstract][Full Text] [Related]
5. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
Yang L; Dan HC; Sun M; Liu Q; Sun XM; Feldman RI; Hamilton AD; Polokoff M; Nicosia SV; Herlyn M; Sebti SM; Cheng JQ
Cancer Res; 2004 Jul; 64(13):4394-9. PubMed ID: 15231645
[TBL] [Abstract][Full Text] [Related]
6. Proapoptotic activity of cell-permeable anti-Akt single-chain antibodies.
Shin I; Edl J; Biswas S; Lin PC; Mernaugh R; Arteaga CL
Cancer Res; 2005 Apr; 65(7):2815-24. PubMed ID: 15805282
[TBL] [Abstract][Full Text] [Related]
7. Protein kinase CK2 phosphorylates and upregulates Akt/PKB.
Di Maira G; Salvi M; Arrigoni G; Marin O; Sarno S; Brustolon F; Pinna LA; Ruzzene M
Cell Death Differ; 2005 Jun; 12(6):668-77. PubMed ID: 15818404
[TBL] [Abstract][Full Text] [Related]
8. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation.
Li Q; Li T; Zhu GD; Gong J; Claibone A; Dalton C; Luo Y; Johnson EF; Shi Y; Liu X; Klinghofer V; Bauch JL; Marsh KC; Bouska JJ; Arries S; De Jong R; Oltersdorf T; Stoll VS; Jakob CG; Rosenberg SH; Giranda VL
Bioorg Med Chem Lett; 2006 Mar; 16(6):1679-85. PubMed ID: 16403626
[TBL] [Abstract][Full Text] [Related]
9. AKT involvement in cisplatin chemoresistance of human uterine cancer cells.
Gagnon V; Mathieu I; Sexton E; Leblanc K; Asselin E
Gynecol Oncol; 2004 Sep; 94(3):785-95. PubMed ID: 15350374
[TBL] [Abstract][Full Text] [Related]
10. Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.
Hartnett JC; Barnett SF; Bilodeau MT; Defeo-Jones D; Hartman GD; Huber HE; Jones RE; Kral AM; Robinson RG; Wu Z
Bioorg Med Chem Lett; 2008 Mar; 18(6):2194-7. PubMed ID: 18294842
[TBL] [Abstract][Full Text] [Related]
11. Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.
Breitenlechner CB; Friebe WG; Brunet E; Werner G; Graul K; Thomas U; Künkele KP; Schäfer W; Gassel M; Bossemeyer D; Huber R; Engh RA; Masjost B
J Med Chem; 2005 Jan; 48(1):163-70. PubMed ID: 15634010
[TBL] [Abstract][Full Text] [Related]
12. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB.
Kandel ES; Hay N
Exp Cell Res; 1999 Nov; 253(1):210-29. PubMed ID: 10579924
[TBL] [Abstract][Full Text] [Related]
13. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Rahmani M; Reese E; Dai Y; Bauer C; Payne SG; Dent P; Spiegel S; Grant S
Cancer Res; 2005 Mar; 65(6):2422-32. PubMed ID: 15781658
[TBL] [Abstract][Full Text] [Related]
14. Pseudosubstrate peptides inhibit Akt and induce cell growth inhibition.
Luo Y; Smith RA; Guan R; Liu X; Klinghofer V; Shen J; Hutchins C; Richardson P; Holzman T; Rosenberg SH; Giranda VL
Biochemistry; 2004 Feb; 43(5):1254-63. PubMed ID: 14756561
[TBL] [Abstract][Full Text] [Related]
15. Rapamycin inhibits Akt-mediated oncogenic transformation and tumor growth.
Liu X; Powlas J; Shi Y; Oleksijew AX; Shoemaker AR; De Jong R; Oltersdorf T; Giranda VL; Luo Y
Anticancer Res; 2004; 24(5A):2697-704. PubMed ID: 15517874
[TBL] [Abstract][Full Text] [Related]
16. Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.
Thomas SA; Li T; Woods KW; Song X; Packard G; Fischer JP; Diebold RB; Liu X; Shi Y; Klinghofer V; Johnson EF; Bouska JJ; Olson A; Guan R; Magnone SR; Marsh K; Luo Y; Rosenberg SH; Giranda VL; Li Q
Bioorg Med Chem Lett; 2006 Jul; 16(14):3740-4. PubMed ID: 16678413
[TBL] [Abstract][Full Text] [Related]
17. Novel 2'-substituted, 3'-deoxy-phosphatidyl-myo-inositol analogues reduce drug resistance in human leukaemia cell lines with an activated phosphoinositide 3-kinase/Akt pathway.
Tabellini G; Tazzari PL; Bortul R; Billi AM; Conte R; Manzoli L; Cocco L; Martelli AM
Br J Haematol; 2004 Aug; 126(4):574-82. PubMed ID: 15287952
[TBL] [Abstract][Full Text] [Related]
18. Discovery of thiophene inhibitors of polo-like kinase.
Emmitte KA; Andrews CW; Badiang JG; Davis-Ward RG; Dickson HD; Drewry DH; Emerson HK; Epperly AH; Hassler DF; Knick VB; Kuntz KW; Lansing TJ; Linn JA; Mook RA; Nailor KE; Salovich JM; Spehar GM; Cheung M
Bioorg Med Chem Lett; 2009 Feb; 19(3):1018-21. PubMed ID: 19097784
[TBL] [Abstract][Full Text] [Related]
19. Rapid assembly of diverse and potent allosteric Akt inhibitors.
Wu Z; Robinson RG; Fu S; Barnett SF; Defeo-Jones D; Jones RE; Kral AM; Huber HE; Kohl NE; Hartman GD; Bilodeau MT
Bioorg Med Chem Lett; 2008 Mar; 18(6):2211-4. PubMed ID: 18296048
[TBL] [Abstract][Full Text] [Related]
20. Hepatocyte growth factor enhances protein phosphatase Cdc25A inhibitor compound 5-induced hepatoma cell growth inhibition via Akt-mediated MAPK pathway.
Wang Z; Wang M; Carr BI
J Cell Physiol; 2005 Jun; 203(3):510-9. PubMed ID: 15534860
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
