222 related articles for article (PubMed ID: 15689163)
1. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Ruchelman AL; Houghton PJ; Zhou N; Liu A; Liu LF; LaVoie EJ
J Med Chem; 2005 Feb; 48(3):792-804. PubMed ID: 15689163
[TBL] [Abstract][Full Text] [Related]
2. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.
Li TK; Houghton PJ; Desai SD; Daroui P; Liu AA; Hars ES; Ruchelman AL; LaVoie EJ; Liu LF
Cancer Res; 2003 Dec; 63(23):8400-7. PubMed ID: 14679002
[TBL] [Abstract][Full Text] [Related]
3. Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide.
Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; LaVoie EJ
Eur J Med Chem; 2009 Sep; 44(9):3433-8. PubMed ID: 19299037
[TBL] [Abstract][Full Text] [Related]
4. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity.
Singh SK; Ruchelman AL; Li TK; Liu A; Liu LF; LaVoie EJ
J Med Chem; 2003 May; 46(11):2254-7. PubMed ID: 12747798
[TBL] [Abstract][Full Text] [Related]
5. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity.
Ruchelman AL; Kerrigan JE; Li TK; Zhou N; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2004 Jul; 12(13):3731-42. PubMed ID: 15186859
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents.
Feng W; Satyanarayana M; Cheng L; Liu A; Tsai YC; Liu LF; LaVoie EJ
Bioorg Med Chem; 2008 Oct; 16(20):9295-301. PubMed ID: 18829334
[TBL] [Abstract][Full Text] [Related]
7. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity.
Ruchelman AL; Zhu S; Zhou N; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem Lett; 2004 Nov; 14(22):5585-9. PubMed ID: 15482929
[TBL] [Abstract][Full Text] [Related]
8. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.
Zhu S; Ruchelman AL; Zhou N; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2006 May; 14(9):3131-43. PubMed ID: 16412652
[TBL] [Abstract][Full Text] [Related]
9. Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.
Feng W; Satyanarayana M; Tsai YC; Liu AA; Liu LF; Lavoie EJ
Bioorg Med Chem Lett; 2008 Jun; 18(12):3570-2. PubMed ID: 18511275
[TBL] [Abstract][Full Text] [Related]
10. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity.
Ruchelman AL; Singh SK; Ray A; Wu XH; Yang JM; Li TK; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2003 May; 11(9):2061-73. PubMed ID: 12670657
[TBL] [Abstract][Full Text] [Related]
11. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity.
Ruchelman AL; Singh SK; Ray A; Wu X; Yang JM; Zhou N; Liu A; Liu LF; LaVoie EJ
Bioorg Med Chem; 2004 Feb; 12(4):795-806. PubMed ID: 14759740
[TBL] [Abstract][Full Text] [Related]
12. Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones.
Sharma L; Tsai YC; Liu AA; Liu LF; LaVoie EJ
Eur J Med Chem; 2009 Apr; 44(4):1471-6. PubMed ID: 19012996
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones.
Deady LW; Rogers ML; Zhuang L; Baguley BC; Denny WA
Bioorg Med Chem; 2005 Feb; 13(4):1341-55. PubMed ID: 15670942
[TBL] [Abstract][Full Text] [Related]
14. 14-Aminocamptothecins: their synthesis, preclinical activity, and potential use for cancer treatment.
Duan JX; Cai X; Meng F; Sun JD; Liu Q; Jung D; Jiao H; Matteucci J; Jung B; Bhupathi D; Ahluwalia D; Huang H; Hart CP; Matteucci M
J Med Chem; 2011 Mar; 54(6):1715-23. PubMed ID: 21341674
[TBL] [Abstract][Full Text] [Related]
15. Antitumor agents. 174. 2',3',4',5,6,7-Substituted 2-phenyl-1,8-naphthyridin-4-ones: their synthesis, cytotoxicity, and inhibition of tubulin polymerization.
Chen K; Kuo SC; Hsieh MC; Mauger A; Lin CM; Hamel E; Lee KH
J Med Chem; 1997 Jul; 40(14):2266-75. PubMed ID: 9216846
[TBL] [Abstract][Full Text] [Related]
16. Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents.
Yu Y; Singh SK; Liu A; Li TK; Liu LF; LaVoie EJ
Bioorg Med Chem; 2003 Apr; 11(7):1475-91. PubMed ID: 12628673
[TBL] [Abstract][Full Text] [Related]
17. Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).
Shen H; Lee FY; Gan J
J Pharmacol Exp Ther; 2011 May; 337(2):423-32. PubMed ID: 21262849
[TBL] [Abstract][Full Text] [Related]
18. Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo.
Leggas M; Panetta JC; Zhuang Y; Schuetz JD; Johnston B; Bai F; Sorrentino B; Zhou S; Houghton PJ; Stewart CF
Cancer Res; 2006 May; 66(9):4802-7. PubMed ID: 16651435
[TBL] [Abstract][Full Text] [Related]
19. Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones.
Martín-Encinas E; Rubiales G; Knudssen BR; Palacios F; Alonso C
Eur J Med Chem; 2019 Sep; 178():752-766. PubMed ID: 31229877
[TBL] [Abstract][Full Text] [Related]
20. HM30181 Derivatives as Novel Potent and Selective Inhibitors of the Breast Cancer Resistance Protein (BCRP/ABCG2).
Köhler SC; Wiese M
J Med Chem; 2015 May; 58(9):3910-21. PubMed ID: 25855895
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
