BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

297 related articles for article (PubMed ID: 15705904)

  • 1. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation.
    Smith JA; Poteet-Smith CE; Xu Y; Errington TM; Hecht SM; Lannigan DA
    Cancer Res; 2005 Feb; 65(3):1027-34. PubMed ID: 15705904
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Influence of rhamnose substituents on the potency of SL0101, an inhibitor of the Ser/Thr kinase, RSK.
    Smith JA; Maloney DJ; Clark DE; Xu Y; Hecht SM; Lannigan DA
    Bioorg Med Chem; 2006 Sep; 14(17):6034-42. PubMed ID: 16723233
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for the activity of the RSK-specific inhibitor, SL0101.
    Smith JA; Maloney DJ; Hecht SM; Lannigan DA
    Bioorg Med Chem; 2007 Jul; 15(14):5018-34. PubMed ID: 17512736
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The serine/threonine protein kinase, p90 ribosomal S6 kinase, is an important regulator of prostate cancer cell proliferation.
    Clark DE; Errington TM; Smith JA; Frierson HF; Weber MJ; Lannigan DA
    Cancer Res; 2005 Apr; 65(8):3108-16. PubMed ID: 15833840
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Two widely used RSK inhibitors, BI-D1870 and SL0101, alter mTORC1 signaling in a RSK-independent manner.
    Roffé M; Lupinacci FC; Soares LC; Hajj GN; Martins VR
    Cell Signal; 2015 Aug; 27(8):1630-42. PubMed ID: 25889895
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of a potent and selective inhibitor of p90 Rsk.
    Maloney DJ; Hecht SM
    Org Lett; 2005 Mar; 7(6):1097-9. PubMed ID: 15760148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Novel potent and selective inhibitors of p90 ribosomal S6 kinase reveal the heterogeneity of RSK function in MAPK-driven cancers.
    Aronchik I; Appleton BA; Basham SE; Crawford K; Del Rosario M; Doyle LV; Estacio WF; Lan J; Lindvall MK; Luu CA; Ornelas E; Venetsanakos E; Shafer CM; Jefferson AB
    Mol Cancer Res; 2014 May; 12(5):803-12. PubMed ID: 24554780
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Y-box binding protein-1 serine 102 is a downstream target of p90 ribosomal S6 kinase in basal-like breast cancer cells.
    Stratford AL; Fry CJ; Desilets C; Davies AH; Cho YY; Li Y; Dong Z; Berquin IM; Roux PP; Dunn SE
    Breast Cancer Res; 2008; 10(6):R99. PubMed ID: 19036157
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Divergent off-target effects of RSK N-terminal and C-terminal kinase inhibitors in cardiac myocytes.
    Stathopoulou K; Schobesberger S; Bork NI; Sprenger JU; Perera RK; Sotoud H; Geertz B; David JP; Christ T; Nikolaev VO; Cuello F
    Cell Signal; 2019 Nov; 63():109362. PubMed ID: 31344438
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Three acetylated flavonol glycosides from Forsteronia refracta that specifically inhibit p90 RSK.
    Xu YM; Smith JA; Lannigan DA; Hecht SM
    Bioorg Med Chem; 2006 Jun; 14(11):3974-7. PubMed ID: 16524738
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enzastaurin, a protein kinase C beta inhibitor, suppresses signaling through the ribosomal S6 kinase and bad pathways and induces apoptosis in human gastric cancer cells.
    Lee KW; Kim SG; Kim HP; Kwon E; You J; Choi HJ; Park JH; Kang BC; Im SA; Kim TY; Kim WH; Bang YJ
    Cancer Res; 2008 Mar; 68(6):1916-26. PubMed ID: 18339873
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Insights into the inhibition of the p90 ribosomal S6 kinase (RSK) by the flavonol glycoside SL0101 from the 1.5 Å crystal structure of the N-terminal domain of RSK2 with bound inhibitor.
    Utepbergenov D; Derewenda U; Olekhnovich N; Szukalska G; Banerjee B; Hilinski MK; Lannigan DA; Stukenberg PT; Derewenda ZS
    Biochemistry; 2012 Aug; 51(33):6499-510. PubMed ID: 22846040
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Paving the way for targeting RSK in cancer.
    Romeo Y; Roux PP
    Expert Opin Ther Targets; 2011 Jan; 15(1):5-9. PubMed ID: 20958120
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1.
    Neise D; Sohn D; Stefanski A; Goto H; Inagaki M; Wesselborg S; Budach W; Stühler K; Jänicke RU
    Cell Death Dis; 2013 Oct; 4(10):e859. PubMed ID: 24136223
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The Clinical Implications of RSK1-3 in Human Breast Cancer.
    Zhao H; Martin TA; Davies EL; Ruge F; Yu H; Zhang Y; Teng XU; Jiang WG
    Anticancer Res; 2016 Mar; 36(3):1267-74. PubMed ID: 26977024
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The RSK family of kinases: emerging roles in cellular signalling.
    Anjum R; Blenis J
    Nat Rev Mol Cell Biol; 2008 Oct; 9(10):747-58. PubMed ID: 18813292
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Regioselective Synthesis of a
    Li Y; Sandusky ZM; Vemula R; Zhang Q; Wu B; Fukuda S; Li M; Lannigan DA; O'Doherty GA
    Org Lett; 2020 Feb; 22(4):1448-1452. PubMed ID: 32009414
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Analogs of the RSK inhibitor SL0101: optimization of in vitro biological stability.
    Hilinski MK; Mrozowski RM; Clark DE; Lannigan DA
    Bioorg Med Chem Lett; 2012 May; 22(9):3244-7. PubMed ID: 22464132
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The MAP kinase ERK5 binds to and phosphorylates p90 RSK.
    Ranganathan A; Pearson GW; Chrestensen CA; Sturgill TW; Cobb MH
    Arch Biochem Biophys; 2006 May; 449(1-2):8-16. PubMed ID: 16626623
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Regulation and function of the RSK family of protein kinases.
    Romeo Y; Zhang X; Roux PP
    Biochem J; 2012 Jan; 441(2):553-69. PubMed ID: 22187936
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.