These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

178 related articles for article (PubMed ID: 15709735)

  • 1. Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment.
    Zhang S; Zhou L; Nemeria N; Yan Y; Zhang Z; Zou Y; Jordan F
    Biochemistry; 2005 Feb; 44(7):2237-43. PubMed ID: 15709735
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit.
    Park YH; Wei W; Zhou L; Nemeria N; Jordan F
    Biochemistry; 2004 Nov; 43(44):14037-46. PubMed ID: 15518552
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Remarkable stabilization of zwitterionic intermediates may account for a billion-fold rate acceleration by thiamin diphosphate-dependent decarboxylases.
    Jordan F; Li H; Brown A
    Biochemistry; 1999 May; 38(20):6369-73. PubMed ID: 10350453
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structural determinants of enzyme binding affinity: the E1 component of pyruvate dehydrogenase from Escherichia coli in complex with the inhibitor thiamin thiazolone diphosphate.
    Arjunan P; Chandrasekhar K; Sax M; Brunskill A; Nemeria N; Jordan F; Furey W
    Biochemistry; 2004 Mar; 43(9):2405-11. PubMed ID: 14992577
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.
    Nemeria N; Korotchkina L; McLeish MJ; Kenyon GL; Patel MS; Jordan F
    Biochemistry; 2007 Sep; 46(37):10739-44. PubMed ID: 17715948
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Competence of Thiamin Diphosphate-Dependent Enzymes with 2'-Methoxythiamin Diphosphate Derived from Bacimethrin, a Naturally Occurring Thiamin Anti-vitamin.
    Nemeria NS; Shome B; DeColli AA; Heflin K; Begley TP; Meyers CF; Jordan F
    Biochemistry; 2016 Feb; 55(7):1135-48. PubMed ID: 26813608
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 2-Oxo-3-alkynoic acids, universal mechanism-based inactivators of thiamin diphosphate-dependent decarboxylases: synthesis and evidence for potent inactivation of the pyruvate dehydrogenase multienzyme complex.
    Brown A; Nemeria N; Yi J; Zhang D; Jordan WB; Machado RS; Guest JR; Jordan F
    Biochemistry; 1997 Jul; 36(26):8071-81. PubMed ID: 9201955
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Systematic study of the six cysteines of the E1 subunit of the pyruvate dehydrogenase multienzyme complex from Escherichia coli: none is essential for activity.
    Nemeria N; Volkov A; Brown A; Yi J; Zipper L; Guest JR; Jordan F
    Biochemistry; 1998 Jan; 37(3):911-22. PubMed ID: 9454581
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Radical phosphate transfer mechanism for the thiamin diphosphate- and FAD-dependent pyruvate oxidase from Lactobacillus plantarum. Kinetic coupling of intercofactor electron transfer with phosphate transfer to acetyl-thiamin diphosphate via a transient FAD semiquinone/hydroxyethyl-ThDP radical pair.
    Tittmann K; Wille G; Golbik R; Weidner A; Ghisla S; Hübner G
    Biochemistry; 2005 Oct; 44(40):13291-303. PubMed ID: 16201755
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tetrahedral intermediates in thiamin diphosphate-dependent decarboxylations exist as a 1',4'-imino tautomeric form of the coenzyme, unlike the michaelis complex or the free coenzyme.
    Nemeria N; Baykal A; Joseph E; Zhang S; Yan Y; Furey W; Jordan F
    Biochemistry; 2004 Jun; 43(21):6565-75. PubMed ID: 15157089
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemistry. How active sites communicate in thiamine enzymes.
    Jordan F
    Science; 2004 Oct; 306(5697):818-20. PubMed ID: 15514144
    [No Abstract]   [Full Text] [Related]  

  • 12. Reaction mechanisms of thiamin diphosphate enzymes: new insights into the role of a conserved glutamate residue.
    Shaanan B; Chipman DM
    FEBS J; 2009 May; 276(9):2447-53. PubMed ID: 19476486
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Direct kinetic evidence for half-of-the-sites reactivity in the E1 component of the human pyruvate dehydrogenase multienzyme complex through alternating sites cofactor activation.
    Seifert F; Golbik R; Brauer J; Lilie H; Schröder-Tittmann K; Hinze E; Korotchkina LG; Patel MS; Tittmann K
    Biochemistry; 2006 Oct; 45(42):12775-85. PubMed ID: 17042496
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular mechanism of regulation of the pyruvate dehydrogenase complex from E. coli.
    Hennig J; Kern G; Neef H; Spinka M; Bisswanger H; Hübner G
    Biochemistry; 1997 Dec; 36(50):15772-9. PubMed ID: 9398307
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A molecular switch and proton wire synchronize the active sites in thiamine enzymes.
    Frank RA; Titman CM; Pratap JV; Luisi BF; Perham RN
    Science; 2004 Oct; 306(5697):872-6. PubMed ID: 15514159
    [TBL] [Abstract][Full Text] [Related]  

  • 16. C2-alpha-lactylthiamin diphosphate is an intermediate on the pathway of thiamin diphosphate-dependent pyruvate decarboxylation. Evidence on enzymes and models.
    Zhang S; Liu M; Yan Y; Zhang Z; Jordan F
    J Biol Chem; 2004 Dec; 279(52):54312-8. PubMed ID: 15501823
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Reaction mechanisms of thiamin diphosphate enzymes: redox reactions.
    Tittmann K
    FEBS J; 2009 May; 276(9):2454-68. PubMed ID: 19476487
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Dual catalytic apparatus of the thiamin diphosphate coenzyme: acid-base via the 1',4'-iminopyrimidine tautomer along with its electrophilic role.
    Jordan F; Nemeria NS; Zhang S; Yan Y; Arjunan P; Furey W
    J Am Chem Soc; 2003 Oct; 125(42):12732-8. PubMed ID: 14558820
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Active-site changes in the pyruvate dehydrogenase multienzyme complex E1 apoenzyme component from Escherichia coli observed at 2.32 A resolution.
    Chandrasekhar K; Arjunan P; Sax M; Nemeria N; Jordan F; Furey W
    Acta Crystallogr D Biol Crystallogr; 2006 Nov; 62(Pt 11):1382-6. PubMed ID: 17057342
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates.
    Schütz A; Golbik R; König S; Hübner G; Tittmann K
    Biochemistry; 2005 Apr; 44(16):6164-79. PubMed ID: 15835904
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.