BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

187 related articles for article (PubMed ID: 15713408)

  • 1. Discovery and SAR of new benzazepines as potent and selective 5-HT(2C) receptor agonists for the treatment of obesity.
    Smith BM; Smith JM; Tsai JH; Schultz JA; Gilson CA; Estrada SA; Chen RR; Park DM; Prieto EB; Gallardo CS; Sengupta D; Thomsen WJ; Saldana HR; Whelan KT; Menzaghi F; Webb RR; Beeley NR
    Bioorg Med Chem Lett; 2005 Mar; 15(5):1467-70. PubMed ID: 15713408
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and structure-activity relationships of a series of benzazepine derivatives as 5-HT2C receptor agonists.
    Shimada I; Maeno K; Kondoh Y; Kaku H; Sugasawa K; Kimura Y; Hatanaka K; Naitou Y; Wanibuchi F; Sakamoto S; Tsukamoto S
    Bioorg Med Chem; 2008 Mar; 16(6):3309-20. PubMed ID: 18083579
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
    Smith BM; Smith JM; Tsai JH; Schultz JA; Gilson CA; Estrada SA; Chen RR; Park DM; Prieto EB; Gallardo CS; Sengupta D; Dosa PI; Covel JA; Ren A; Webb RR; Beeley NR; Martin M; Morgan M; Espitia S; Saldana HR; Bjenning C; Whelan KT; Grottick AJ; Menzaghi F; Thomsen WJ
    J Med Chem; 2008 Jan; 51(2):305-13. PubMed ID: 18095642
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of pyridazinone-based 5-HT(2C) agonists.
    Allerton CM; Andrews MD; Blagg J; Ellis D; Evrard E; Green MP; Liu KK; McMurray G; Ralph M; Sanderson V; Ward R; Watson L
    Bioorg Med Chem Lett; 2009 Oct; 19(19):5791-5. PubMed ID: 19716297
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents.
    Ahmad S; Ngu K; Miller KJ; Wu G; Hung CP; Malmstrom S; Zhang G; O'Tanyi E; Keim WJ; Cullen MJ; Rohrbach KW; Thomas M; Ung T; Qu Q; Gan J; Narayanan R; Pelleymounter MA; Robl JA
    Bioorg Med Chem Lett; 2010 Feb; 20(3):1128-33. PubMed ID: 20022752
    [TBL] [Abstract][Full Text] [Related]  

  • 6. WAY-163909 [(7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino[6,7,1hi]indole], a novel 5-hydroxytryptamine 2C receptor-selective agonist with anorectic activity.
    Dunlop J; Sabb AL; Mazandarani H; Zhang J; Kalgaonker S; Shukhina E; Sukoff S; Vogel RL; Stack G; Schechter L; Harrison BL; Rosenzweig-Lipson S
    J Pharmacol Exp Ther; 2005 May; 313(2):862-9. PubMed ID: 15705738
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 7-Sulfonamido-3-benzazepines as potent and selective 5-HT2C receptor agonists: hit-to-lead optimization.
    Fish PV; Brown AD; Evrard E; Roberts LR
    Bioorg Med Chem Lett; 2009 Apr; 19(7):1871-5. PubMed ID: 19269173
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells.
    Cussac D; Boutet-Robinet E; Ailhaud MC; Newman-Tancredi A; Martel JC; Danty N; Rauly-Lestienne I
    Eur J Pharmacol; 2008 Oct; 594(1-3):32-8. PubMed ID: 18703043
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pyrrolo(iso)quinoline derivatives as 5-HT(2C) receptor agonists.
    Adams DR; Bentley JM; Benwell KR; Bickerdike MJ; Bodkin CD; Cliffe IA; Dourish CT; George AR; Kennett GA; Knight AR; Malcolm CS; Mansell HL; Misra A; Quirk K; Roffey JR; Vickers SP
    Bioorg Med Chem Lett; 2006 Feb; 16(3):677-80. PubMed ID: 16257207
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of piperazinylpyrimidinones as novel selective 5-HT(2C) agonists.
    Andrews MD; Green MP; Allerton CM; Batchelor DV; Blagg J; Brown AD; Gordon DW; McMurray G; Millns DJ; Nichols CL; Watson L
    Bioorg Med Chem Lett; 2009 Sep; 19(18):5346-50. PubMed ID: 19692241
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
    Chambers JJ; Parrish JC; Jensen NH; Kurrasch-Orbaugh DM; Marona-Lewicka D; Nichols DE
    J Med Chem; 2003 Jul; 46(16):3526-35. PubMed ID: 12877591
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Lorcaserin, a novel selective human 5-hydroxytryptamine2C agonist: in vitro and in vivo pharmacological characterization.
    Thomsen WJ; Grottick AJ; Menzaghi F; Reyes-Saldana H; Espitia S; Yuskin D; Whelan K; Martin M; Morgan M; Chen W; Al-Shamma H; Smith B; Chalmers D; Behan D
    J Pharmacol Exp Ther; 2008 May; 325(2):577-87. PubMed ID: 18252809
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Position 5.46 of the serotonin 5-HT2A receptor contributes to a species-dependent variation for the 5-HT2C agonist (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one: impact on selectivity and toxicological evaluation.
    Miller KJ; Wu GY; Varnes JG; Levesque P; Li J; Li D; Robl JA; Rossi KA; Wacker DA
    Mol Pharmacol; 2009 Dec; 76(6):1211-9. PubMed ID: 19767451
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.
    Zhao G; Kwon C; Bisaha SN; Stein PD; Rossi KA; Cao X; Ung T; Wu G; Hung CP; Malmstrom SE; Zhang G; Qu Q; Gan J; Keim WJ; Cullen MJ; Rohrbach KW; Devenny J; Pelleymounter MA; Miller KJ; Robl JA
    Bioorg Med Chem Lett; 2013 Jul; 23(13):3914-9. PubMed ID: 23683593
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists.
    Fevig JM; Feng J; Rossi KA; Miller KJ; Wu G; Hung CP; Ung T; Malmstrom SE; Zhang G; Keim WJ; Cullen MJ; Rohrbach KW; Qu Q; Gan J; Pelleymounter MA; Robl JA
    Bioorg Med Chem Lett; 2013 Jan; 23(1):330-5. PubMed ID: 23177783
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
    Takeda H; Sadakane C; Hattori T; Katsurada T; Ohkawara T; Nagai K; Asaka M
    Gastroenterology; 2008 Jun; 134(7):2004-13. PubMed ID: 18439428
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.
    Fletcher PJ; Tampakeras M; Sinyard J; Slassi A; Isaac M; Higgins GA
    Neuropharmacology; 2009 Sep; 57(3):259-67. PubMed ID: 19501602
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.
    Brennan PE; Whitlock GA; Ho DK; Conlon K; McMurray G
    Bioorg Med Chem Lett; 2009 Sep; 19(17):4999-5003. PubMed ID: 19646865
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists.
    Braden MR; Parrish JC; Naylor JC; Nichols DE
    Mol Pharmacol; 2006 Dec; 70(6):1956-64. PubMed ID: 17000863
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.
    Röver S; Adams DR; Bénardeau A; Bentley JM; Bickerdike MJ; Bourson A; Cliffe IA; Coassolo P; Davidson JE; Dourish CT; Hebeisen P; Kennett GA; Knight AR; Malcolm CS; Mattei P; Misra A; Mizrahi J; Muller M; Porter RH; Richter H; Taylor S; Vickers SP
    Bioorg Med Chem Lett; 2005 Aug; 15(15):3604-8. PubMed ID: 15975787
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.