198 related articles for article (PubMed ID: 15715652)
21. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex.
Shiraishi H; Marutani T; Wang HQ; Maeda Y; Kurono Y; Takashima A; Araki W; Nishimura M; Yanagisawa K; Komano H
Genes Cells; 2006 Jan; 11(1):83-93. PubMed ID: 16371134
[TBL] [Abstract][Full Text] [Related]
22. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
De Strooper B; Annaert W; Cupers P; Saftig P; Craessaerts K; Mumm JS; Schroeter EH; Schrijvers V; Wolfe MS; Ray WJ; Goate A; Kopan R
Nature; 1999 Apr; 398(6727):518-22. PubMed ID: 10206645
[TBL] [Abstract][Full Text] [Related]
23. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
24. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
25. CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer's disease amyloid beta-peptide production.
Zhou S; Zhou H; Walian PJ; Jap BK
Proc Natl Acad Sci U S A; 2005 May; 102(21):7499-504. PubMed ID: 15890777
[TBL] [Abstract][Full Text] [Related]
26. The gamma-secretase complex: membrane-embedded proteolytic ensemble.
Wolfe MS
Biochemistry; 2006 Jul; 45(26):7931-9. PubMed ID: 16800619
[TBL] [Abstract][Full Text] [Related]
27. A conserved GXXXG motif in APH-1 is critical for assembly and activity of the gamma-secretase complex.
Lee SF; Shah S; Yu C; Wigley WC; Li H; Lim M; Pedersen K; Han W; Thomas P; Lundkvist J; Hao YH; Yu G
J Biol Chem; 2004 Feb; 279(6):4144-52. PubMed ID: 14627705
[TBL] [Abstract][Full Text] [Related]
28. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation.
Wang J; Beher D; Nyborg AC; Shearman MS; Golde TE; Goate A
J Neurochem; 2006 Jan; 96(1):218-27. PubMed ID: 16305624
[TBL] [Abstract][Full Text] [Related]
29. Purification and characterization of the human gamma-secretase complex.
Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
[TBL] [Abstract][Full Text] [Related]
30. Minor contribution of presenilin 2 for γ-secretase activity in mouse embryonic fibroblasts and adult mouse brain.
Frånberg J; Svensson AI; Winblad B; Karlström H; Frykman S
Biochem Biophys Res Commun; 2011 Jan; 404(1):564-8. PubMed ID: 21146496
[TBL] [Abstract][Full Text] [Related]
31. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R; McGrath G; Zhang J; Ruddy DA; Sym M; Apfeld J; Nicoll M; Maxwell M; Hai B; Ellis MC; Parks AL; Xu W; Li J; Gurney M; Myers RL; Himes CS; Hiebsch R; Ruble C; Nye JS; Curtis D
Dev Cell; 2002 Jul; 3(1):85-97. PubMed ID: 12110170
[TBL] [Abstract][Full Text] [Related]
32. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.
Chyung JH; Raper DM; Selkoe DJ
J Biol Chem; 2005 Feb; 280(6):4383-92. PubMed ID: 15569674
[TBL] [Abstract][Full Text] [Related]
33. Visualization of specific γ-secretase complexes using bimolecular fluorescence complementation.
Meckler X; Checler F
J Alzheimers Dis; 2014; 40(1):161-76. PubMed ID: 24413617
[TBL] [Abstract][Full Text] [Related]
34. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
Kimberly WT; Esler WP; Ye W; Ostaszewski BL; Gao J; Diehl T; Selkoe DJ; Wolfe MS
Biochemistry; 2003 Jan; 42(1):137-44. PubMed ID: 12515548
[TBL] [Abstract][Full Text] [Related]
35. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
Wolfe MS; Xia W; Ostaszewski BL; Diehl TS; Kimberly WT; Selkoe DJ
Nature; 1999 Apr; 398(6727):513-7. PubMed ID: 10206644
[TBL] [Abstract][Full Text] [Related]
36. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex.
De Strooper B
Neuron; 2003 Apr; 38(1):9-12. PubMed ID: 12691659
[TBL] [Abstract][Full Text] [Related]
37. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes.
Gu Y; Chen F; Sanjo N; Kawarai T; Hasegawa H; Duthie M; Li W; Ruan X; Luthra A; Mount HT; Tandon A; Fraser PE; St George-Hyslop P
J Biol Chem; 2003 Feb; 278(9):7374-80. PubMed ID: 12471034
[TBL] [Abstract][Full Text] [Related]
38. Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.
Zhang L; Lee J; Song L; Sun X; Shen J; Terracina G; Parker EM
Biochemistry; 2005 Mar; 44(11):4450-7. PubMed ID: 15766275
[TBL] [Abstract][Full Text] [Related]
39. In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand.
Beher D; Fricker M; Nadin A; Clarke EE; Wrigley JD; Li YM; Culvenor JG; Masters CL; Harrison T; Shearman MS
Biochemistry; 2003 Jul; 42(27):8133-42. PubMed ID: 12846562
[TBL] [Abstract][Full Text] [Related]
40. A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities.
Brunkan AL; Martinez M; Wang J; Walker ES; Goate AM
J Neurochem; 2005 Mar; 92(5):1158-69. PubMed ID: 15715666
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
