364 related articles for article (PubMed ID: 15720121)
1. Bioactivation of the selective estrogen receptor modulator acolbifene to quinone methides.
Liu J; Liu H; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):174-82. PubMed ID: 15720121
[TBL] [Abstract][Full Text] [Related]
2. Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation.
Liu H; Liu J; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2005 Feb; 18(2):162-73. PubMed ID: 15720120
[TBL] [Abstract][Full Text] [Related]
3. Bioactivation of tamoxifen to metabolite E quinone methide: reaction with glutathione and DNA.
Fan PW; Bolton JL
Drug Metab Dispos; 2001 Jun; 29(6):891-6. PubMed ID: 11353759
[TBL] [Abstract][Full Text] [Related]
4. Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.
Iverson SL; Shen L; Anlar N; Bolton JL
Chem Res Toxicol; 1996 Mar; 9(2):492-9. PubMed ID: 8839054
[TBL] [Abstract][Full Text] [Related]
5. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
Fan PW; Zhang F; Bolton JL
Chem Res Toxicol; 2000 Jan; 13(1):45-52. PubMed ID: 10649966
[TBL] [Abstract][Full Text] [Related]
6. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
[TBL] [Abstract][Full Text] [Related]
7. Oxidation of raloxifene to quinoids: potential toxic pathways via a diquinone methide and o-quinones.
Yu L; Liu H; Li W; Zhang F; Luckie C; van Breemen RB; Thatcher GR; Bolton JL
Chem Res Toxicol; 2004 Jul; 17(7):879-88. PubMed ID: 15257612
[TBL] [Abstract][Full Text] [Related]
8. The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.
Zhang F; Chen Y; Pisha E; Shen L; Xiong Y; van Breemen RB; Bolton JL
Chem Res Toxicol; 1999 Feb; 12(2):204-13. PubMed ID: 10027800
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.
Zhang F; Fan PW; Liu X; Shen L; van Breemen RB; Bolton JL
Chem Res Toxicol; 2000 Jan; 13(1):53-62. PubMed ID: 10649967
[TBL] [Abstract][Full Text] [Related]
10. Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Liu H; Qin Z; Thatcher GR; Bolton JL
Chem Res Toxicol; 2007 Nov; 20(11):1676-84. PubMed ID: 17630709
[TBL] [Abstract][Full Text] [Related]
11. Quenching of quercetin quinone/quinone methides by different thiolate scavengers: stability and reversibility of conjugate formation.
Awad HM; Boersma MG; Boeren S; Van Bladeren PJ; Vervoort J; Rietjens IM
Chem Res Toxicol; 2003 Jul; 16(7):822-31. PubMed ID: 12870884
[TBL] [Abstract][Full Text] [Related]
12. NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Zhao SX; Dalvie DK; Kelly JM; Soglia JR; Frederick KS; Smith EB; Obach RS; Kalgutkar AS
Chem Res Toxicol; 2007 Nov; 20(11):1649-57. PubMed ID: 17907785
[TBL] [Abstract][Full Text] [Related]
13. Alkylation of 2'-deoxynucleosides and DNA by quinone methides derived from 2,6-di-tert-butyl-4-methylphenol.
Lewis MA; Yoerg DG; Bolton JL; Thompson JA
Chem Res Toxicol; 1996 Dec; 9(8):1368-74. PubMed ID: 8951242
[TBL] [Abstract][Full Text] [Related]
14. Oxo substituents markedly alter the phase II metabolism of alpha-hydroxybutenylbenzenes: models probing the bioactivation mechanisms of tamoxifen.
Ramakrishna KV; Fan PW; Boyer CS; Dalvie D; Bolton JL
Chem Res Toxicol; 1997 Aug; 10(8):887-94. PubMed ID: 9282838
[TBL] [Abstract][Full Text] [Related]
15. Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.
Deng P; Zhong D; Nan F; Liu S; Li D; Yuan T; Chen X; Zheng J
Chem Res Toxicol; 2010 Oct; 23(10):1617-28. PubMed ID: 20843008
[TBL] [Abstract][Full Text] [Related]
16. Nitrosation, nitration, and autoxidation of the selective estrogen receptor modulator raloxifene by nitric oxide, peroxynitrite, and reactive nitrogen/oxygen species.
Toader V; Xu X; Nicolescu A; Yu L; Bolton JL; Thatcher GR
Chem Res Toxicol; 2003 Oct; 16(10):1264-76. PubMed ID: 14565768
[TBL] [Abstract][Full Text] [Related]
17. Development and evaluation of an electrochemical method for studying reactive phase-I metabolites: correlation to in vitro drug metabolism.
Madsen KG; Olsen J; Skonberg C; Hansen SH; Jurva U
Chem Res Toxicol; 2007 May; 20(5):821-31. PubMed ID: 17447796
[TBL] [Abstract][Full Text] [Related]
18. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
Yan Z; Easterwood LM; Maher N; Torres R; Huebert N; Yost GS
Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
[TBL] [Abstract][Full Text] [Related]
19. Bioactivation of 4-methylphenol (p-cresol) via cytochrome P450-mediated aromatic oxidation in human liver microsomes.
Yan Z; Zhong HM; Maher N; Torres R; Leo GC; Caldwell GW; Huebert N
Drug Metab Dispos; 2005 Dec; 33(12):1867-76. PubMed ID: 16174805
[TBL] [Abstract][Full Text] [Related]
20. Mechanism of isomerization of 4-propyl-o-quinone to its tautomeric p-quinone methide.
Bolton JL; Wu HM; Hu LQ
Chem Res Toxicol; 1996; 9(1):109-113. PubMed ID: 8924578
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]