These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
3. Drug-target residence time and its implications for lead optimization. Copeland RA; Pompliano DL; Meek TD Nat Rev Drug Discov; 2006 Sep; 5(9):730-9. PubMed ID: 16888652 [TBL] [Abstract][Full Text] [Related]
4. Designing transient binding drugs: a new concept for drug discovery. Ohlson S Drug Discov Today; 2008 May; 13(9-10):433-9. PubMed ID: 18468561 [TBL] [Abstract][Full Text] [Related]
5. Wrapping mimicking in drug-like small molecules disruptive of protein-protein interfaces. Accordino SR; Morini MA; Sierra MB; Fris JA; Appignanesi GA; Fernández A Proteins; 2012 Jul; 80(7):1755-65. PubMed ID: 22422633 [TBL] [Abstract][Full Text] [Related]
6. Modulation of biomolecular interactions with complex-binding small molecules. Cai Z; Greene MI; Berezov A Methods; 2008 Sep; 46(1):39-46. PubMed ID: 18571508 [TBL] [Abstract][Full Text] [Related]
8. Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design. Ladbury JE Biochem Soc Trans; 2010 Aug; 38(4):888-93. PubMed ID: 20658972 [TBL] [Abstract][Full Text] [Related]
9. [Capacity limited pharmacokinetics, a mechanism of drug toxicity (author's transl)]. Dettli L Arzneimittelforschung; 1977; 27(96):1844-8. PubMed ID: 579151 [TBL] [Abstract][Full Text] [Related]
10. Strategies for dealing with reactive intermediates in drug discovery and development. Nassar AE; Lopez-Anaya A Curr Opin Drug Discov Devel; 2004 Jan; 7(1):126-36. PubMed ID: 14982156 [TBL] [Abstract][Full Text] [Related]
11. Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery. Pérot S; Sperandio O; Miteva MA; Camproux AC; Villoutreix BO Drug Discov Today; 2010 Aug; 15(15-16):656-67. PubMed ID: 20685398 [TBL] [Abstract][Full Text] [Related]
12. Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States. Stepan AF; Walker DP; Bauman J; Price DA; Baillie TA; Kalgutkar AS; Aleo MD Chem Res Toxicol; 2011 Sep; 24(9):1345-410. PubMed ID: 21702456 [TBL] [Abstract][Full Text] [Related]
13. Natural products and Pharma 2011: strategic changes spur new opportunities. Carter GT Nat Prod Rep; 2011 Oct; 28(11):1783-9. PubMed ID: 21909580 [TBL] [Abstract][Full Text] [Related]
14. Characterization of interfacial solvent in protein complexes and contribution of wet spots to the interface description. Teyra J; Pisabarro MT Proteins; 2007 Jun; 67(4):1087-95. PubMed ID: 17397062 [TBL] [Abstract][Full Text] [Related]
15. Drug Discovery Technology and Development 2005 - IBC's Tenth World Congress. Protein-protein interactions, biomarkers and RNAi. Pagliaro L IDrugs; 2005 Oct; 8(10):793-5. PubMed ID: 16254793 [No Abstract] [Full Text] [Related]
16. Investigation of molecular interaction within biological macromolecular complexes by mass spectrometry. Akashi S Med Res Rev; 2006 May; 26(3):339-68. PubMed ID: 16463282 [TBL] [Abstract][Full Text] [Related]
17. A large-scale computational approach to drug repositioning. Li YY; An J; Jones SJ Genome Inform; 2006; 17(2):239-47. PubMed ID: 17503396 [TBL] [Abstract][Full Text] [Related]
18. Therapeutic potential of natural product signal transduction agents. Koehn FE Curr Opin Biotechnol; 2006 Dec; 17(6):631-7. PubMed ID: 17049224 [TBL] [Abstract][Full Text] [Related]
19. Electrophoretic deposition of biological macromolecules, drugs, and cells. Seuss S; Boccaccini AR Biomacromolecules; 2013 Oct; 14(10):3355-69. PubMed ID: 24001091 [TBL] [Abstract][Full Text] [Related]
20. Determination of drug binding to microtubules in vitro. Smith JA; Jordan MA Methods Cell Biol; 2010; 95():289-99. PubMed ID: 20466141 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]