146 related articles for article (PubMed ID: 15764596)
1. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.
Nakaya Y; Yamane T; Shiraishi H; Wang HQ; Matsubara E; Sato T; Dolios G; Wang R; De Strooper B; Shoji M; Komano H; Yanagisawa K; Ihara Y; Fraser P; St George-Hyslop P; Nishimura M
J Biol Chem; 2005 May; 280(19):19070-7. PubMed ID: 15764596
[TBL] [Abstract][Full Text] [Related]
2. Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology.
Beher D; Wrigley JD; Nadin A; Evin G; Masters CL; Harrison T; Castro JL; Shearman MS
J Biol Chem; 2001 Nov; 276(48):45394-402. PubMed ID: 11574530
[TBL] [Abstract][Full Text] [Related]
3. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Moehlmann T; Winkler E; Xia X; Edbauer D; Murrell J; Capell A; Kaether C; Zheng H; Ghetti B; Haass C; Steiner H
Proc Natl Acad Sci U S A; 2002 Jun; 99(12):8025-30. PubMed ID: 12048239
[TBL] [Abstract][Full Text] [Related]
4. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
5. Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria.
Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
J Biol Chem; 2004 Dec; 279(49):51654-60. PubMed ID: 15456764
[TBL] [Abstract][Full Text] [Related]
6. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants.
Murphy MP; Uljon SN; Golde TE; Wang R
Biochim Biophys Acta; 2002 Mar; 1586(2):199-209. PubMed ID: 11959461
[TBL] [Abstract][Full Text] [Related]
7. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
8. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
Kaether C; Lammich S; Edbauer D; Ertl M; Rietdorf J; Capell A; Steiner H; Haass C
J Cell Biol; 2002 Aug; 158(3):551-61. PubMed ID: 12147673
[TBL] [Abstract][Full Text] [Related]
9. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis.
Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
J Biol Chem; 2004 Jun; 279(23):23925-32. PubMed ID: 15051718
[TBL] [Abstract][Full Text] [Related]
10. Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.
Futai E; Yagishita S; Ishiura S
J Biol Chem; 2009 May; 284(19):13013-22. PubMed ID: 19254953
[TBL] [Abstract][Full Text] [Related]
11. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.
Xia W
Exp Gerontol; 2000 Jul; 35(4):453-60. PubMed ID: 10959033
[TBL] [Abstract][Full Text] [Related]
12. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E; Cottrell BA; Leuchtenberger S; Kukar T; Ladd TB; Esselmann H; Paul S; Schubenel R; Torpey JW; Pietrzik CU; Golde TE; Wiltfang J; Baumann K; Koo EH; Weggen S
J Biol Chem; 2008 Jun; 283(25):17049-54. PubMed ID: 18426795
[TBL] [Abstract][Full Text] [Related]
13. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio.
Uemura K; Lill CM; Li X; Peters JA; Ivanov A; Fan Z; DeStrooper B; Bacskai BJ; Hyman BT; Berezovska O
PLoS One; 2009 Nov; 4(11):e7893. PubMed ID: 19924286
[TBL] [Abstract][Full Text] [Related]
14. Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.
Pardossi-Piquard R; Petit A; Kawarai T; Sunyach C; Alves da Costa C; Vincent B; Ring S; D'Adamio L; Shen J; Müller U; St George Hyslop P; Checler F
Neuron; 2005 May; 46(4):541-54. PubMed ID: 15944124
[TBL] [Abstract][Full Text] [Related]
15. Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Kim SH; Ikeuchi T; Yu C; Sisodia SS
J Biol Chem; 2003 Sep; 278(36):33992-4002. PubMed ID: 12821663
[TBL] [Abstract][Full Text] [Related]
16. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.
Steiner H; Winkler E; Shearman MS; Prywes R; Haass C
Neurobiol Dis; 2001 Aug; 8(4):717-22. PubMed ID: 11493036
[TBL] [Abstract][Full Text] [Related]
17. Conserved "PAL" sequence in presenilins is essential for gamma-secretase activity, but not required for formation or stabilization of gamma-secretase complexes.
Wang J; Brunkan AL; Hecimovic S; Walker E; Goate A
Neurobiol Dis; 2004 Apr; 15(3):654-66. PubMed ID: 15056474
[TBL] [Abstract][Full Text] [Related]
18. Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Ikeuchi T; Dolios G; Kim SH; Wang R; Sisodia SS
J Biol Chem; 2003 Feb; 278(9):7010-8. PubMed ID: 12493731
[TBL] [Abstract][Full Text] [Related]
19. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
20. Functional implications of the presenilin dimerization: reconstitution of gamma-secretase activity by assembly of a catalytic site at the dimer interface of two catalytically inactive presenilins.
Cervantes S; Saura CA; Pomares E; Gonzàlez-Duarte R; Marfany G
J Biol Chem; 2004 Aug; 279(35):36519-29. PubMed ID: 15220354
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]