647 related articles for article (PubMed ID: 15766241)
1. Sequence-selective interaction of the minor-groove interstrand cross-linking agent SJG-136 with naked and cellular DNA: footprinting and enzyme inhibition studies.
Martin C; Ellis T; McGurk CJ; Jenkins TC; Hartley JA; Waring MJ; Thurston DE
Biochemistry; 2005 Mar; 44(11):4135-47. PubMed ID: 15766241
[TBL] [Abstract][Full Text] [Related]
2. The pyrrolobenzodiazepine dimer SJG-136 forms sequence-dependent intrastrand DNA cross-links and monoalkylated adducts in addition to interstrand cross-links.
Rahman KM; Thompson AS; James CH; Narayanaswamy M; Thurston DE
J Am Chem Soc; 2009 Sep; 131(38):13756-66. PubMed ID: 19725510
[TBL] [Abstract][Full Text] [Related]
3. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity.
Hartley JA; Spanswick VJ; Brooks N; Clingen PH; McHugh PJ; Hochhauser D; Pedley RB; Kelland LR; Alley MC; Schultz R; Hollingshead MG; Schweikart KM; Tomaszewski JE; Sausville EA; Gregson SJ; Howard PW; Thurston DE
Cancer Res; 2004 Sep; 64(18):6693-9. PubMed ID: 15374986
[TBL] [Abstract][Full Text] [Related]
4. An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.
Tiberghien AC; Evans DA; Kiakos K; Martin CR; Hartley JA; Thurston DE; Howard PW
Bioorg Med Chem Lett; 2008 Mar; 18(6):2073-7. PubMed ID: 18272367
[TBL] [Abstract][Full Text] [Related]
5. The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill.
Pepper CJ; Hambly RM; Fegan CD; Delavault P; Thurston DE
Cancer Res; 2004 Sep; 64(18):6750-5. PubMed ID: 15374993
[TBL] [Abstract][Full Text] [Related]
6. Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.
Gregson SJ; Howard PW; Gullick DR; Hamaguchi A; Corcoran KE; Brooks NA; Hartley JA; Jenkins TC; Patel S; Guille MJ; Thurston DE
J Med Chem; 2004 Feb; 47(5):1161-74. PubMed ID: 14971896
[TBL] [Abstract][Full Text] [Related]
7. Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136.
Hopton SR; Thompson AS
Biochemistry; 2011 May; 50(21):4720-32. PubMed ID: 21488658
[TBL] [Abstract][Full Text] [Related]
8. Sequence-selective recognition of duplex DNA through covalent interstrand cross-linking: kinetic and molecular modeling studies with pyrrolobenzodiazepine dimers.
Smellie M; Bose DS; Thompson AS; Jenkins TC; Hartley JA; Thurston DE
Biochemistry; 2003 Jul; 42(27):8232-9. PubMed ID: 12846572
[TBL] [Abstract][Full Text] [Related]
9. Highly efficient sequence-specific DNA interstrand cross-linking by pyrrole/imidazole CPI conjugates.
Bando T; Narita A; Saito I; Sugiyama H
J Am Chem Soc; 2003 Mar; 125(12):3471-85. PubMed ID: 12643709
[TBL] [Abstract][Full Text] [Related]
10. Studies on the interaction of T7 RNA polymerase with a DNA template containing a site-specifically placed psoralen cross-link. I. Characterization of elongation complexes.
Sastry SS; Hearst JE
J Mol Biol; 1991 Oct; 221(4):1091-110. PubMed ID: 1942044
[TBL] [Abstract][Full Text] [Related]
11. SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations.
Alley MC; Hollingshead MG; Pacula-Cox CM; Waud WR; Hartley JA; Howard PW; Gregson SJ; Thurston DE; Sausville EA
Cancer Res; 2004 Sep; 64(18):6700-6. PubMed ID: 15374987
[TBL] [Abstract][Full Text] [Related]
12. Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells.
Pepper C; Lowe H; Fegan C; Thurieau C; Thurston DE; Hartley JA; Delavault P
Br J Cancer; 2007 Jul; 97(2):253-9. PubMed ID: 17579621
[TBL] [Abstract][Full Text] [Related]
13. Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards.
McClean S; Costelloe C; Denny WA; Searcey M; Wakelin LP
Anticancer Drug Des; 1999 Jun; 14(3):187-204. PubMed ID: 10500495
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of bacteriophage T7 RNA polymerase in vitro transcription by DNA-binding pyrrolo[2,1-c][1,4]benzodiazepines.
Puvvada MS; Forrow SA; Hartley JA; Stephenson P; Gibson I; Jenkins TC; Thurston DE
Biochemistry; 1997 Mar; 36(9):2478-84. PubMed ID: 9054552
[TBL] [Abstract][Full Text] [Related]
15. Structure of a covalent DNA minor groove adduct with a pyrrolobenzodiazepine dimer: evidence for sequence-specific interstrand cross-linking.
Jenkins TC; Hurley LH; Neidle S; Thurston DE
J Med Chem; 1994 Dec; 37(26):4529-37. PubMed ID: 7799403
[TBL] [Abstract][Full Text] [Related]
16. Interactions of pyrrolobenzodiazepine dimers and duplex DNA from methicillin-resistant Staphylococcus aureus.
Hadjivassileva T; Stapleton PD; Thurston DE; Taylor PW
Int J Antimicrob Agents; 2007 Jun; 29(6):672-8. PubMed ID: 17350809
[TBL] [Abstract][Full Text] [Related]
17. Identification of the template-binding cleft of T7 RNA polymerase as the site for promoter binding by photochemical cross-linking with psoralen.
Sastry SS
Biochemistry; 1996 Oct; 35(42):13519-30. PubMed ID: 8885831
[TBL] [Abstract][Full Text] [Related]
18. Sequence-specific DNA binding of the phage Mu C protein: footprinting analysis reveals altered DNA conformation upon protein binding.
Ramesh V; Nagaraja V
J Mol Biol; 1996 Jul; 260(1):22-33. PubMed ID: 8676390
[TBL] [Abstract][Full Text] [Related]
19. Pyrrolobenzodiazepine dimers: novel sequence-selective, DNA-interactive, cross-linking agents with activity against Gram-positive bacteria.
Hadjivassileva T; Thurston DE; Taylor PW
J Antimicrob Chemother; 2005 Sep; 56(3):513-8. PubMed ID: 16024592
[TBL] [Abstract][Full Text] [Related]
20. Sequence recognition in the minor groove of DNA by covalently linked formamido imidazole-pyrrole-imidazole polyamides: effect of H-pin linkage and linker length on selectivity and affinity.
O'Hare CC; Uthe P; Mackay H; Blackmon K; Jones J; Brown T; Nguyen B; Wilson WD; Lee M; Hartley JA
Biochemistry; 2007 Oct; 46(42):11661-70. PubMed ID: 17910471
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
