BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

222 related articles for article (PubMed ID: 15808862)

  • 1. Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
    Kumar A; Mandiyan V; Suzuki Y; Zhang C; Rice J; Tsai J; Artis DR; Ibrahim P; Bremer R
    J Mol Biol; 2005 Apr; 348(1):183-93. PubMed ID: 15808862
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase.
    Qian KC; Wang L; Hickey ER; Studts J; Barringer K; Peng C; Kronkaitis A; Li J; White A; Mische S; Farmer B
    J Biol Chem; 2005 Feb; 280(7):6130-7. PubMed ID: 15525646
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
    Jacobs MD; Black J; Futer O; Swenson L; Hare B; Fleming M; Saxena K
    J Biol Chem; 2005 Apr; 280(14):13728-34. PubMed ID: 15657054
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure of the catalytic domain of human polo-like kinase 1.
    Kothe M; Kohls D; Low S; Coli R; Cheng AC; Jacques SL; Johnson TL; Lewis C; Loh C; Nonomiya J; Sheils AL; Verdries KA; Wynn TA; Kuhn C; Ding YH
    Biochemistry; 2007 May; 46(20):5960-71. PubMed ID: 17461553
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity.
    Pogacic V; Bullock AN; Fedorov O; Filippakopoulos P; Gasser C; Biondi A; Meyer-Monard S; Knapp S; Schwaller J
    Cancer Res; 2007 Jul; 67(14):6916-24. PubMed ID: 17638903
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants.
    Breitenlechner CB; Friebe WG; Brunet E; Werner G; Graul K; Thomas U; Künkele KP; Schäfer W; Gassel M; Bossemeyer D; Huber R; Engh RA; Masjost B
    J Med Chem; 2005 Jan; 48(1):163-70. PubMed ID: 15634010
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Selectivity-determining residues in Plk1.
    Kothe M; Kohls D; Low S; Coli R; Rennie GR; Feru F; Kuhn C; Ding YH
    Chem Biol Drug Des; 2007 Dec; 70(6):540-6. PubMed ID: 18005335
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structures of the wild-type and activated catalytic domains of Brachydanio rerio Polo-like kinase 1 (Plk1): changes in the active-site conformation and interactions with ligands.
    Elling RA; Fucini RV; Romanowski MJ
    Acta Crystallogr D Biol Crystallogr; 2008 Sep; 64(Pt 9):909-18. PubMed ID: 18703838
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors.
    Olla S; Manetti F; Crespan E; Maga G; Angelucci A; Schenone S; Bologna M; Botta M
    Bioorg Med Chem Lett; 2009 Mar; 19(5):1512-6. PubMed ID: 19179076
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The 2.35 A crystal structure of the inactivated form of chicken Src: a dynamic molecule with multiple regulatory interactions.
    Williams JC; Weijland A; Gonfloni S; Thompson A; Courtneidge SA; Superti-Furga G; Wierenga RK
    J Mol Biol; 1997 Dec; 274(5):757-75. PubMed ID: 9405157
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
    Lee CC; Jia Y; Li N; Sun X; Ng K; Ambing E; Gao MY; Hua S; Chen C; Kim S; Michellys PY; Lesley SA; Harris JL; Spraggon G
    Biochem J; 2010 Sep; 430(3):425-37. PubMed ID: 20632993
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutants of protein kinase A that mimic the ATP-binding site of protein kinase B (AKT).
    Gassel M; Breitenlechner CB; Rüger P; Jucknischke U; Schneider T; Huber R; Bossemeyer D; Engh RA
    J Mol Biol; 2003 Jun; 329(5):1021-34. PubMed ID: 12798691
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas.
    Kreuz S; Holmes KB; Tooze RM; Lefevre PF
    Mol Cancer; 2015 Dec; 14():205. PubMed ID: 26643319
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling.
    Tong Y; Stewart KD; Thomas S; Przytulinska M; Johnson EF; Klinghofer V; Leverson J; McCall O; Soni NB; Luo Y; Lin NH; Sowin TJ; Giranda VL; Penning TD
    Bioorg Med Chem Lett; 2008 Oct; 18(19):5206-8. PubMed ID: 18790640
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site.
    Jauch R; Jäkel S; Netter C; Schreiter K; Aicher B; Jäckle H; Wahl MC
    Structure; 2005 Oct; 13(10):1559-68. PubMed ID: 16216586
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP.
    Yang J; Cron P; Good VM; Thompson V; Hemmings BA; Barford D
    Nat Struct Biol; 2002 Dec; 9(12):940-4. PubMed ID: 12434148
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis for compound C inhibition of the human AMP-activated protein kinase α2 subunit kinase domain.
    Handa N; Takagi T; Saijo S; Kishishita S; Takaya D; Toyama M; Terada T; Shirouzu M; Suzuki A; Lee S; Yamauchi T; Okada-Iwabu M; Iwabu M; Kadowaki T; Minokoshi Y; Yokoyama S
    Acta Crystallogr D Biol Crystallogr; 2011 May; 67(Pt 5):480-7. PubMed ID: 21543851
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Crystal structures of ADP and AMPPNP-bound propionate kinase (TdcD) from Salmonella typhimurium: comparison with members of acetate and sugar kinase/heat shock cognate 70/actin superfamily.
    Simanshu DK; Savithri HS; Murthy MR
    J Mol Biol; 2005 Sep; 352(4):876-92. PubMed ID: 16139298
    [TBL] [Abstract][Full Text] [Related]  

  • 19. PIM1 kinase as a target for cancer therapy.
    Merkel AL; Meggers E; Ocker M
    Expert Opin Investig Drugs; 2012 Apr; 21(4):425-36. PubMed ID: 22385334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The serine/threonine kinase Pim-1.
    Bachmann M; Möröy T
    Int J Biochem Cell Biol; 2005 Apr; 37(4):726-30. PubMed ID: 15694833
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.