These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

143 related articles for article (PubMed ID: 15812028)

  • 1. Production of novel rapamycin analogs by precursor-directed biosynthesis.
    Ritacco FV; Graziani EI; Summers MY; Zabriskie TM; Yu K; Bernan VS; Carter GT; Greenstein M
    Appl Environ Microbiol; 2005 Apr; 71(4):1971-6. PubMed ID: 15812028
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis.
    Graziani EI; Ritacco FV; Summers MY; Zabriskie TM; Yu K; Bernan VS; Greenstein M; Carter GT
    Org Lett; 2003 Jul; 5(14):2385-8. PubMed ID: 12841736
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Biosynthesis of rapamycin and its regulation: past achievements and recent progress.
    Park SR; Yoo YJ; Ban YH; Yoon YJ
    J Antibiot (Tokyo); 2010 Aug; 63(8):434-41. PubMed ID: 20588302
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutational biosynthesis of novel rapamycins by a strain of Streptomyces hygroscopicus NRRL 5491 disrupted in rapL, encoding a putative lysine cyclodeaminase.
    Khaw LE; Böhm GA; Metcalfe S; Staunton J; Leadlay PF
    J Bacteriol; 1998 Feb; 180(4):809-14. PubMed ID: 9473033
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of amino acids on rapamycin biosynthesis by Streptomyces hygroscopicus.
    Cheng YR; Fang A; Demain AL
    Appl Microbiol Biotechnol; 1995 Nov; 43(6):1096-8. PubMed ID: 8590661
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.
    Jung WS; Yoo YJ; Park JW; Park SR; Han AR; Ban YH; Kim EJ; Kim E; Yoon YJ
    Appl Microbiol Biotechnol; 2011 Sep; 91(5):1389-97. PubMed ID: 21655985
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Insights into the metabolic mechanism of rapamycin overproduction in the shikimate-resistant Streptomyces hygroscopicus strain UV-II using comparative metabolomics.
    Geng H; Liu H; Liu J; Wang C; Wen J
    World J Microbiol Biotechnol; 2017 Jun; 33(6):101. PubMed ID: 28466297
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Elucidating the substrate specificity and condensation domain activity of FkbP, the FK520 pipecolate-incorporating enzyme.
    Gatto GJ; McLoughlin SM; Kelleher NL; Walsh CT
    Biochemistry; 2005 Apr; 44(16):5993-6002. PubMed ID: 15835888
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Roles of rapH and rapG in positive regulation of rapamycin biosynthesis in Streptomyces hygroscopicus.
    Kuscer E; Coates N; Challis I; Gregory M; Wilkinson B; Sheridan R; Petković H
    J Bacteriol; 2007 Jul; 189(13):4756-63. PubMed ID: 17468238
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Comparative metabolic profiling-based improvement of rapamycin production by Streptomyces hygroscopicus.
    Zhao S; Huang D; Qi H; Wen J; Jia X
    Appl Microbiol Biotechnol; 2013 Jun; 97(12):5329-41. PubMed ID: 23604534
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparative metabolic profiling reveals the key role of amino acids metabolism in the rapamycin overproduction by Streptomyces hygroscopicus.
    Wang B; Liu J; Liu H; Huang D; Wen J
    J Ind Microbiol Biotechnol; 2015 Jun; 42(6):949-63. PubMed ID: 25840873
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Organisation of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of genes flanking the polyketide synthase.
    Molnár I; Aparicio JF; Haydock SF; Khaw LE; Schwecke T; König A; Staunton J; Leadlay PF
    Gene; 1996 Feb; 169(1):1-7. PubMed ID: 8635730
    [TBL] [Abstract][Full Text] [Related]  

  • 13. An overview of rapamycin: from discovery to future perspectives.
    Yoo YJ; Kim H; Park SR; Yoon YJ
    J Ind Microbiol Biotechnol; 2017 May; 44(4-5):537-553. PubMed ID: 27613310
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Deletion of rapQONML from the rapamycin gene cluster of Streptomyces hygroscopicus gives production of the 16-O-desmethyl-27-desmethoxy analog.
    Chung L; Liu L; Patel S; Carney JR; Reeves CD
    J Antibiot (Tokyo); 2001 Mar; 54(3):250-6. PubMed ID: 11372782
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Generation of high rapamycin producing strain via rational metabolic pathway-based mutagenesis and further titer improvement with fed-batch bioprocess optimization.
    Zhu X; Zhang W; Chen X; Wu H; Duan Y; Xu Z
    Biotechnol Bioeng; 2010 Oct; 107(3):506-15. PubMed ID: 20517869
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Studies on process optimization methods for rapamycin production using Streptomyces hygroscopicus ATCC 29253.
    Sinha R; Singh S; Srivastava P
    Bioprocess Biosyst Eng; 2014 May; 37(5):829-40. PubMed ID: 24048754
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of the nocardiopsin biosynthetic gene cluster reveals similarities to and differences from the rapamycin and FK-506 pathways.
    Bis DM; Ban YH; James ED; Alqahtani N; Viswanathan R; Lane AL
    Chembiochem; 2015 Apr; 16(6):990-7. PubMed ID: 25755076
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Isolation and characterization of pre-rapamycin, the first macrocyclic intermediate in the biosynthesis of the immunosuppressant rapamycin by S. hygroscopicus.
    Gregory MA; Gaisser S; Lill RE; Hong H; Sheridan RM; Wilkinson B; Petkovic H; Weston AJ; Carletti I; Lee HL; Staunton J; Leadlay PF
    Angew Chem Int Ed Engl; 2004 May; 43(19):2551-3. PubMed ID: 15127450
    [No Abstract]   [Full Text] [Related]  

  • 19. Comparative analysis of rapamycin biosynthesis clusters between Actinoplanes sp. N902-109 and Streptomyces hygroscopicus ATCC29253.
    Huang H; Ren SX; Yang S; Hu HF
    Chin J Nat Med; 2015 Feb; 13(2):90-8. PubMed ID: 25769891
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recent advances in the chemistry, biosynthesis and pharmacology of rapamycin analogs.
    Graziani EI
    Nat Prod Rep; 2009 May; 26(5):602-9. PubMed ID: 19387497
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.