150 related articles for article (PubMed ID: 15845901)
1. PEP005, a selective small-molecule activator of protein kinase C, has potent antileukemic activity mediated via the delta isoform of PKC.
Hampson P; Chahal H; Khanim F; Hayden R; Mulder A; Assi LK; Bunce CM; Lord JM
Blood; 2005 Aug; 106(4):1362-8. PubMed ID: 15845901
[TBL] [Abstract][Full Text] [Related]
2. Novel antileukemic compound ingenol 3-angelate inhibits T cell apoptosis by activating protein kinase Ctheta.
Lee WY; Hampson P; Coulthard L; Ali F; Salmon M; Lord JM; Scheel-Toellner D
J Biol Chem; 2010 Jul; 285(31):23889-98. PubMed ID: 20472553
[TBL] [Abstract][Full Text] [Related]
3. Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells.
Serova M; Ghoul A; Benhadji KA; Faivre S; Le Tourneau C; Cvitkovic E; Lokiec F; Lord J; Ogbourne SM; Calvo F; Raymond E
Mol Cancer Ther; 2008 Apr; 7(4):915-22. PubMed ID: 18413805
[TBL] [Abstract][Full Text] [Related]
4. Ingenol 3-angelate induces dual modes of cell death and differentially regulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in melanoma cells.
Gillespie SK; Zhang XD; Hersey P
Mol Cancer Ther; 2004 Dec; 3(12):1651-8. PubMed ID: 15634659
[TBL] [Abstract][Full Text] [Related]
5. Kinetics of ERK1/2 activation determine sensitivity of acute myeloid leukaemia cells to the induction of apoptosis by the novel small molecule ingenol 3-angelate (PEP005).
Hampson P; Wang K; Milverton L; Ersvaer E; Bruserud O; Lord JM
Apoptosis; 2010 Aug; 15(8):946-55. PubMed ID: 20467815
[TBL] [Abstract][Full Text] [Related]
6. The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-delta dependent manner.
Hampson P; Kavanagh D; Smith E; Wang K; Lord JM; Ed Rainger G
Cancer Immunol Immunother; 2008 Aug; 57(8):1241-51. PubMed ID: 18265980
[TBL] [Abstract][Full Text] [Related]
7. Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells.
Benhadji KA; Serova M; Ghoul A; Cvitkovic E; Le Tourneau C; Ogbourne SM; Lokiec F; Calvo F; Hammel P; Faivre S; Raymond E
Br J Cancer; 2008 Dec; 99(11):1808-15. PubMed ID: 19034280
[TBL] [Abstract][Full Text] [Related]
8. Proceedings of the First International Conference on PEP005.
Ogbourne SM; Hampson P; Lord JM; Parsons P; De Witte PA; Suhrbier A
Anticancer Drugs; 2007 Mar; 18(3):357-62. PubMed ID: 17264770
[TBL] [Abstract][Full Text] [Related]
9. The protein kinase C agonist PEP005 increases NF-kappaB expression, induces differentiation and increases constitutive chemokine release by primary acute myeloid leukaemia cells.
Olsnes AM; Ersvaer E; Ryningen A; Paulsen K; Hampson P; Lord JM; Gjertsen BT; Kristoffersen EK; Bruserud Ø
Br J Haematol; 2009 Jun; 145(6):761-74. PubMed ID: 19388934
[TBL] [Abstract][Full Text] [Related]
10. The protein kinase C agonist PEP005 (ingenol 3-angelate) in the treatment of human cancer: a balance between efficacy and toxicity.
Ersvaer E; Kittang AO; Hampson P; Sand K; Gjertsen BT; Lord JM; Bruserud O
Toxins (Basel); 2010 Jan; 2(1):174-94. PubMed ID: 22069553
[TBL] [Abstract][Full Text] [Related]
11. Targeting Cutaneous T-Cell Lymphoma Cells by Ingenol Mebutate (PEP005) Correlates with PKCδ Activation, ROS Induction as Well as Downregulation of XIAP and c-FLIP.
Sumarni U; Reidel U; Eberle J
Cells; 2021 Apr; 10(5):. PubMed ID: 33922439
[TBL] [Abstract][Full Text] [Related]
12. Treosulfan-induced apoptosis in acute myeloid leukemia cells is accompanied by translocation of protein kinase C delta and enhanced by bryostatin-1.
Schmidmaier R; Oellerich M; Baumgart J; Emmerich B; Meinhardt G
Exp Hematol; 2004 Jan; 32(1):76-86. PubMed ID: 14725904
[TBL] [Abstract][Full Text] [Related]
13. Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells.
Ghoul A; Serova M; Astorgues-Xerri L; Bieche I; Bousquet G; Varna M; Vidaud M; Phillips E; Weill S; Benhadji KA; Lokiec F; Cvitkovic E; Faivre S; Raymond E
Cancer Res; 2009 May; 69(10):4260-9. PubMed ID: 19417139
[TBL] [Abstract][Full Text] [Related]
14. Activation of protein kinase C prevents induction of apoptosis by geranylgeraniol in human leukemia HL60 cells.
Masuda Y; Yoda M; Ohizumi H; Aiuchi T; Watabe M; Nakajo S; Nakaya K
Int J Cancer; 1997 May; 71(4):691-7. PubMed ID: 9178828
[TBL] [Abstract][Full Text] [Related]
15. Effect of novel modulators of protein kinase C activity upon chemotherapy-induced differentiation and apoptosis in myeloid leukemic cells.
Meinhardt G; Eppinger E; Schmidmaier R
Anticancer Drugs; 2002 Aug; 13(7):725-33. PubMed ID: 12187329
[TBL] [Abstract][Full Text] [Related]
16. Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-kappaB independent pathway.
Blanco-Molina M; Tron GC; Macho A; Lucena C; Calzado MA; Muñoz E; Appendino G
Chem Biol; 2001 Aug; 8(8):767-78. PubMed ID: 11514226
[TBL] [Abstract][Full Text] [Related]
17. Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.
Challacombe JM; Suhrbier A; Parsons PG; Jones B; Hampson P; Kavanagh D; Rainger GE; Morris M; Lord JM; Le TT; Hoang-Le D; Ogbourne SM
J Immunol; 2006 Dec; 177(11):8123-32. PubMed ID: 17114487
[TBL] [Abstract][Full Text] [Related]
18. Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.
Tillman DM; Izeradjene K; Szucs KS; Douglas L; Houghton JA
Cancer Res; 2003 Aug; 63(16):5118-25. PubMed ID: 12941843
[TBL] [Abstract][Full Text] [Related]
19. Natural Product Vibsanin A Induces Differentiation of Myeloid Leukemia Cells through PKC Activation.
Yu ZY; Xiao H; Wang LM; Shen X; Jing Y; Wang L; Sun WF; Zhang YF; Cui Y; Shan YJ; Zhou WB; Xing S; Xiong GL; Liu XL; Dong B; Feng JN; Wang LS; Luo QL; Zhao QS; Cong YW
Cancer Res; 2016 May; 76(9):2698-709. PubMed ID: 26984756
[TBL] [Abstract][Full Text] [Related]
20. Modulation of protein kinase C activity and calcium-sensitive isoform expression in human myeloid leukemia cells by bryostatin 1: relationship to differentiation and ara-C-induced apoptosis.
Grant S; Turner AJ; Freemerman AJ; Wang Z; Kramer L; Jarvis WD
Exp Cell Res; 1996 Oct; 228(1):65-75. PubMed ID: 8892972
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]