556 related articles for article (PubMed ID: 15848208)
1. Synthesis and biological evaluation of a new class of acyl derivatives of 3-amino-1-phenyl-4,5-dihydro-1H-pyrazol-5-one as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Apr; 60(4):327-32. PubMed ID: 15848208
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and biological evaluation of new phenidone analogues as potential dual cyclooxygenase (COX-1 and COX-2) and human lipoxygenase (5-LOX) inhibitors.
Cusan C; Spalluto G; Prato M; Adams M; Bodensieck A; Bauer R; Tubaro A; Bernardi P; Da Ros T
Farmaco; 2005 Jan; 60(1):7-13. PubMed ID: 15652362
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
4. Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA; Abdellatif KR; Dong Y; Das D; Suresh MR; Knaus EE
Bioorg Med Chem Lett; 2008 Dec; 18(23):6138-41. PubMed ID: 18945614
[TBL] [Abstract][Full Text] [Related]
5. 3-(2-Methoxytetrahydrofuran-2-yl)pyrazoles: a novel class of potent, selective cyclooxygenase-2 (COX-2) inhibitors.
Ranatunge RR; Earl RA; Garvey DS; Janero DR; Letts LG; Martino AM; Murty MG; Richardson SK; Schwalb DJ; Young DV; Zemtseva IS
Bioorg Med Chem Lett; 2004 Dec; 14(24):6049-52. PubMed ID: 15546727
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.
Yu G; Praveen Rao PN; Chowdhury MA; Abdellatif KR; Dong Y; Das D; Velázquez CA; Suresh MR; Knaus EE
Bioorg Med Chem Lett; 2010 Apr; 20(7):2168-73. PubMed ID: 20202839
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
[TBL] [Abstract][Full Text] [Related]
8. Synthesis of 1,5-diarylpyrazol-3-propanoic acids towards inhibition of cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4 formation.
Ergün BC; Nuñez MT; Labeaga L; Ledo F; Darlington J; Bain G; Cakir B; Banoglu E
Arzneimittelforschung; 2010; 60(8):497-505. PubMed ID: 20863006
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of 3-[4-(amino/methylsulfonyl)phenyl]methylene-indolin-2-one derivatives as novel COX-1/2 and 5-LOX inhibitors.
Lai Y; Ma L; Huang W; Yu X; Zhang Y; Ji H; Tian J
Bioorg Med Chem Lett; 2010 Dec; 20(24):7349-53. PubMed ID: 21055929
[TBL] [Abstract][Full Text] [Related]
10. Enzyme selectivity of new cyclooxygenase-2/5 lipoxygenase inhibitors using molecular modeling approach.
Kothekar V; Sahi S; Mishra J
Indian J Biochem Biophys; 2000 Apr; 37(2):86-96. PubMed ID: 10983419
[TBL] [Abstract][Full Text] [Related]
11. New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
Janusz JM; Young PA; Ridgeway JM; Scherz MW; Enzweiler K; Wu LI; Gan L; Chen J; Kellstein DE; Green SA; Tulich JL; Rosario-Jansen T; Magrisso IJ; Wehmeyer KR; Kuhlenbeck DL; Eichhold TH; Dobson RL
J Med Chem; 1998 Aug; 41(18):3515-29. PubMed ID: 9719605
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.
Reddy MV; Billa VK; Pallela VR; Mallireddigari MR; Boominathan R; Gabriel JL; Reddy EP
Bioorg Med Chem; 2008 Apr; 16(7):3907-16. PubMed ID: 18272371
[TBL] [Abstract][Full Text] [Related]
13. Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.
Li Y; Chen SH; Ou TM; Tan JH; Li D; Gu LQ; Huang ZS
Bioorg Med Chem; 2011 Mar; 19(6):2074-83. PubMed ID: 21349729
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA; Abdellatif KR; Dong Y; Das D; Suresh MR; Knaus EE
J Med Chem; 2009 Mar; 52(6):1525-9. PubMed ID: 19296694
[TBL] [Abstract][Full Text] [Related]
15. Synthesis of 4,5-diaryl-1H-pyrazole-3-ol derivatives as potential COX-2 inhibitors.
Patel MV; Bell R; Majest S; Henry R; Kolasa T
J Org Chem; 2004 Oct; 69(21):7058-65. PubMed ID: 15471453
[TBL] [Abstract][Full Text] [Related]
16. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Chen QH; Praveen Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7716-27. PubMed ID: 16931030
[TBL] [Abstract][Full Text] [Related]
17. Computer-aided discovery of anti-inflammatory thiazolidinones with dual cyclooxygenase/lipoxygenase inhibition.
Geronikaki AA; Lagunin AA; Hadjipavlou-Litina DI; Eleftheriou PT; Filimonov DA; Poroikov VV; Alam I; Saxena AK
J Med Chem; 2008 Mar; 51(6):1601-9. PubMed ID: 18311898
[TBL] [Abstract][Full Text] [Related]
18. New COX-2/5-LOX inhibitors: apoptosis-inducing agents potentially useful in prostate cancer chemotherapy.
Pommery N; Taverne T; Telliez A; Goossens L; Charlier C; Pommery J; Goossens JF; Houssin R; Durant F; Hénichart JP
J Med Chem; 2004 Dec; 47(25):6195-206. PubMed ID: 15566290
[TBL] [Abstract][Full Text] [Related]
19. Discovery of 3-(4-bromophenyl)-6-nitrobenzo[1.3.2]dithiazolium ylide 1,1-dioxide as a novel dual cyclooxygenase/5-lipoxygenase inhibitor that also inhibits tumor necrosis factor-alpha production.
Chen CS; Tan CM; Huang CH; Chang LC; Wang JP; Cheng FC; Chern JW
Bioorg Med Chem; 2010 Jan; 18(2):597-604. PubMed ID: 20056549
[TBL] [Abstract][Full Text] [Related]
20. Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): molecular docking and 3D-QSAR analyses on DHDMBF analogues.
Zheng M; Zhang Z; Zhu W; Liu H; Luo X; Chen K; Jiang H
Bioorg Med Chem; 2006 May; 14(10):3428-37. PubMed ID: 16458008
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
