152 related articles for article (PubMed ID: 15849197)
1. N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity.
Poon CJ; Plaas AH; Keene DR; McQuillan DJ; Last K; Fosang AJ
J Biol Chem; 2005 Jun; 280(25):23615-21. PubMed ID: 15849197
[TBL] [Abstract][Full Text] [Related]
2. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
Mercuri FA; Doege KJ; Arner EC; Pratta MA; Last K; Fosang AJ
J Biol Chem; 1999 Nov; 274(45):32387-95. PubMed ID: 10542281
[TBL] [Abstract][Full Text] [Related]
3. Keratan sulphate in the interglobular domain has a microstructure that is distinct from keratan sulphate elsewhere on pig aggrecan.
Fosang AJ; Last K; Poon CJ; Plaas AH
Matrix Biol; 2009 Jan; 28(1):53-61. PubMed ID: 19041721
[TBL] [Abstract][Full Text] [Related]
4. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
Mercuri FA; Maciewicz RA; Tart J; Last K; Fosang AJ
J Biol Chem; 2000 Oct; 275(42):33038-45. PubMed ID: 11032846
[TBL] [Abstract][Full Text] [Related]
5. Utilization of a recombinant substrate rAgg1 to study the biochemical properties of aggrecanase in cell culture systems.
Hughes CE; Büttner FH; Eidenmüller B; Caterson B; Bartnik E
J Biol Chem; 1997 Aug; 272(32):20269-74. PubMed ID: 9242707
[TBL] [Abstract][Full Text] [Related]
6. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
Fosang AJ; Neame PJ; Last K; Hardingham TE; Murphy G; Hamilton JA
J Biol Chem; 1992 Sep; 267(27):19470-4. PubMed ID: 1326552
[TBL] [Abstract][Full Text] [Related]
7. Age-related changes in aggrecan glycosylation affect cleavage by aggrecanase.
Pratta MA; Tortorella MD; Arner EC
J Biol Chem; 2000 Dec; 275(50):39096-102. PubMed ID: 10991945
[TBL] [Abstract][Full Text] [Related]
8. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
Lark MW; Gordy JT; Weidner JR; Ayala J; Kimura JH; Williams HR; Mumford RA; Flannery CR; Carlson SS; Iwata M
J Biol Chem; 1995 Feb; 270(6):2550-6. PubMed ID: 7852317
[TBL] [Abstract][Full Text] [Related]
9. Hyaluronan-binding region of aggrecan from pig laryngeal cartilage. Amino acid sequence, analysis of N-linked oligosaccharides and location of the keratan sulphate.
Barry FP; Gaw JU; Young CN; Neame PJ
Biochem J; 1992 Sep; 286 ( Pt 3)(Pt 3):761-9. PubMed ID: 1417734
[TBL] [Abstract][Full Text] [Related]
10. A novel keratan sulphate domain preferentially expressed on the large aggregating proteoglycan from human articular cartilage is recognized by the monoclonal antibody 3D12/H7.
Fischer DC; Haubeck HD; Eich K; Kolbe-Busch S; Stöcker G; Stuhlsatz HW; Greiling H
Biochem J; 1996 Sep; 318 ( Pt 3)(Pt 3):1051-6. PubMed ID: 8836155
[TBL] [Abstract][Full Text] [Related]
11. Immunity to the G1 globular domain of the cartilage proteoglycan aggrecan can induce inflammatory erosive polyarthritis and spondylitis in BALB/c mice but immunity to G1 is inhibited by covalently bound keratan sulfate in vitro and in vivo.
Leroux JY; Guerassimov A; Cartman A; Delaunay N; Webber C; Rosenberg LC; Banerjee S; Poole AR
J Clin Invest; 1996 Feb; 97(3):621-32. PubMed ID: 8609216
[TBL] [Abstract][Full Text] [Related]
12. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
Tortorella MD; Pratta M; Liu RQ; Austin J; Ross OH; Abbaszade I; Burn T; Arner E
J Biol Chem; 2000 Jun; 275(24):18566-73. PubMed ID: 10751421
[TBL] [Abstract][Full Text] [Related]
13. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
Büttner FH; Hughes CE; Margerie D; Lichte A; Tschesche H; Caterson B; Bartnik E
Biochem J; 1998 Jul; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
[TBL] [Abstract][Full Text] [Related]
14. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
Sandy JD; Flannery CR; Neame PJ; Lohmander LS
J Clin Invest; 1992 May; 89(5):1512-6. PubMed ID: 1569188
[TBL] [Abstract][Full Text] [Related]
15. N- and O-linked keratan sulfate on the hyaluronan binding region of aggrecan from mature and immature bovine cartilage.
Barry FP; Rosenberg LC; Gaw JU; Gaw JU; Koob TJ; Neame PJ
J Biol Chem; 1995 Sep; 270(35):20516-24. PubMed ID: 7657627
[TBL] [Abstract][Full Text] [Related]
16. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
Hughes CE; Caterson B; Fosang AJ; Roughley PJ; Mort JS
Biochem J; 1995 Feb; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
[TBL] [Abstract][Full Text] [Related]
17. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
Fosang AJ; Last K; Gardiner P; Jackson DC; Brown L
Biochem J; 1995 Aug; 310 ( Pt 1)(Pt 1):337-43. PubMed ID: 7544117
[TBL] [Abstract][Full Text] [Related]
18. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Lohmander LS; Neame PJ; Sandy JD
Arthritis Rheum; 1993 Sep; 36(9):1214-22. PubMed ID: 8216415
[TBL] [Abstract][Full Text] [Related]
19. Human aggrecan keratan sulfate undergoes structural changes during adolescent development.
Brown GM; Huckerby TN; Bayliss MT; Nieduszynski IA
J Biol Chem; 1998 Oct; 273(41):26408-14. PubMed ID: 9756873
[TBL] [Abstract][Full Text] [Related]
20. Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Oshita H; Sandy JD; Suzuki K; Akaike A; Bai Y; Sasaki T; Shimizu K
Biochem J; 2004 Aug; 382(Pt 1):253-9. PubMed ID: 15175011
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
