599 related articles for article (PubMed ID: 15851852)
1. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.
Shi XP; Tugusheva K; Bruce JE; Lucka A; Chen-Dodson E; Hu B; Wu GX; Price E; Register RB; Lineberger J; Miller R; Tang MJ; Espeseth A; Kahana J; Wolfe A; Crouthamel MC; Sankaranarayanan S; Simon A; Chen L; Lai MT; Pietrak B; DiMuzio J; Li Y; Xu M; Huang Q; Garsky V; Sardana MK; Hazuda DJ
J Alzheimers Dis; 2005 Apr; 7(2):139-48; discussion 173-80. PubMed ID: 15851852
[TBL] [Abstract][Full Text] [Related]
2. Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence.
Kimura A; Hata S; Suzuki T
J Biol Chem; 2016 Nov; 291(46):24041-24053. PubMed ID: 27687728
[TBL] [Abstract][Full Text] [Related]
3. Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.
Deng Y; Wang Z; Wang R; Zhang X; Zhang S; Wu Y; Staufenbiel M; Cai F; Song W
Eur J Neurosci; 2013 Jun; 37(12):1962-9. PubMed ID: 23773065
[TBL] [Abstract][Full Text] [Related]
4. Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity.
Shi XP; Tugusheva K; Bruce JE; Lucka A; Wu GX; Chen-Dodson E; Price E; Li Y; Xu M; Huang Q; Sardana MK; Hazuda DJ
J Biol Chem; 2003 Jun; 278(23):21286-94. PubMed ID: 12665519
[TBL] [Abstract][Full Text] [Related]
5. Swedish mutant APP-based BACE1 binding site peptide reduces APP β-cleavage and cerebral Aβ levels in Alzheimer's mice.
Li S; Hou H; Mori T; Sawmiller D; Smith A; Tian J; Wang Y; Giunta B; Sanberg PR; Zhang S; Tan J
Sci Rep; 2015 Jun; 5():11322. PubMed ID: 26091071
[TBL] [Abstract][Full Text] [Related]
6. The beta-secretase, BACE: a prime drug target for Alzheimer's disease.
Vassar R
J Mol Neurosci; 2001 Oct; 17(2):157-70. PubMed ID: 11816789
[TBL] [Abstract][Full Text] [Related]
7. BACE1: the beta-secretase enzyme in Alzheimer's disease.
Vassar R
J Mol Neurosci; 2004; 23(1-2):105-14. PubMed ID: 15126696
[TBL] [Abstract][Full Text] [Related]
8. Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.
Vetrivel KS; Barman A; Chen Y; Nguyen PD; Wagner SL; Prabhakar R; Thinakaran G
J Biol Chem; 2011 Jul; 286(29):26166-77. PubMed ID: 21642424
[TBL] [Abstract][Full Text] [Related]
9. BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis.
Zhang S; Wang Z; Cai F; Zhang M; Wu Y; Zhang J; Song W
J Neurosci; 2017 Jul; 37(29):6915-6925. PubMed ID: 28626014
[TBL] [Abstract][Full Text] [Related]
10. Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product.
Wu G; Sankaranarayanan S; Montgomery DL; Simon AJ; An Z; Savage MJ
Protein Cell; 2011 Jul; 2(7):573-84. PubMed ID: 21822802
[TBL] [Abstract][Full Text] [Related]
11. Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein.
Maloney JA; Bainbridge T; Gustafson A; Zhang S; Kyauk R; Steiner P; van der Brug M; Liu Y; Ernst JA; Watts RJ; Atwal JK
J Biol Chem; 2014 Nov; 289(45):30990-1000. PubMed ID: 25253696
[TBL] [Abstract][Full Text] [Related]
12. Employing a superior BACE1 cleavage sequence to probe cellular APP processing.
Tomasselli AG; Qahwash I; Emmons TL; Lu Y; Leone JW; Lull JM; Fok KF; Bannow CA; Smith CW; Bienkowski MJ; Heinrikson RL; Yan R
J Neurochem; 2003 Mar; 84(5):1006-17. PubMed ID: 12603825
[TBL] [Abstract][Full Text] [Related]
13. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.
Sun X; Wang Y; Qing H; Christensen MA; Liu Y; Zhou W; Tong Y; Xiao C; Huang Y; Zhang S; Liu X; Song W
FASEB J; 2005 May; 19(7):739-49. PubMed ID: 15857888
[TBL] [Abstract][Full Text] [Related]
14. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing.
Rabe S; Reichwald J; Ammaturo D; de Strooper B; Saftig P; Neumann U; Staufenbiel M
J Neurochem; 2011 Oct; 119(1):231-9. PubMed ID: 21812781
[TBL] [Abstract][Full Text] [Related]
15. Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease.
Ye X; Feng T; Tammineni P; Chang Q; Jeong YY; Margolis DJ; Cai H; Kusnecov A; Cai Q
J Neurosci; 2017 Mar; 37(10):2639-2655. PubMed ID: 28159908
[TBL] [Abstract][Full Text] [Related]
16. Amyloid precursor protein compartmentalization restricts beta-amyloid production: therapeutic targets based on BACE compartmentalization.
Gandhi S; Refolo LM; Sambamurti K
J Mol Neurosci; 2004; 24(1):137-43. PubMed ID: 15314262
[TBL] [Abstract][Full Text] [Related]
17. Effects of BACE1 haploinsufficiency on APP processing and Aβ concentrations in male and female 5XFAD Alzheimer mice at different disease stages.
Devi L; Ohno M
Neuroscience; 2015 Oct; 307():128-37. PubMed ID: 26314636
[TBL] [Abstract][Full Text] [Related]
18. Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis.
Velliquette RA; O'Connor T; Vassar R
J Neurosci; 2005 Nov; 25(47):10874-83. PubMed ID: 16306400
[TBL] [Abstract][Full Text] [Related]
19. Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Thinakaran G; Teplow DB; Siman R; Greenberg B; Sisodia SS
J Biol Chem; 1996 Apr; 271(16):9390-7. PubMed ID: 8621605
[TBL] [Abstract][Full Text] [Related]
20. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.
Yamamoto M; Kiyota T; Horiba M; Buescher JL; Walsh SM; Gendelman HE; Ikezu T
Am J Pathol; 2007 Feb; 170(2):680-92. PubMed ID: 17255335
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
