BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

472 related articles for article (PubMed ID: 15853645)

  • 1. Recent advances in the development of selective small molecule inhibitors for cyclin-dependent kinases.
    Hirai H; Kawanishi N; Iwasawa Y
    Curr Top Med Chem; 2005; 5(2):167-79. PubMed ID: 15853645
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.
    Rossi KA; Markwalder JA; Seitz SP; Chang CH; Cox S; Boisclair MD; Brizuela L; Brenner SL; Stouten PF
    J Comput Aided Mol Des; 2005 Feb; 19(2):111-22. PubMed ID: 16075305
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects.
    Mettey Y; Gompel M; Thomas V; Garnier M; Leost M; Ceballos-Picot I; Noble M; Endicott J; Vierfond JM; Meijer L
    J Med Chem; 2003 Jan; 46(2):222-36. PubMed ID: 12519061
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loop flexibility and solvent dynamics as determinants for the selective inhibition of cyclin-dependent kinase 4: comparative molecular dynamics simulation studies of CDK2 and CDK4.
    Park H; Yeom MS; Lee S
    Chembiochem; 2004 Dec; 5(12):1662-72. PubMed ID: 15505811
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors.
    Ruetz S; Fabbro D; Zimmermann J; Meyer T; Gray N
    Curr Med Chem Anticancer Agents; 2003 Jan; 3(1):1-14. PubMed ID: 12678910
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.
    Barvian M; Boschelli DH; Cossrow J; Dobrusin E; Fattaey A; Fritsch A; Fry D; Harvey P; Keller P; Garrett M; La F; Leopold W; McNamara D; Quin M; Trumpp-Kallmeyer S; Toogood P; Wu Z; Zhang E
    J Med Chem; 2000 Nov; 43(24):4606-16. PubMed ID: 11101352
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation.
    Gao CY; Rampalli AM; Cai HC; He HY; Zelenka PS
    Exp Eye Res; 1999 Dec; 69(6):695-703. PubMed ID: 10620399
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
    Meijer L; Borgne A; Mulner O; Chong JP; Blow JJ; Inagaki N; Inagaki M; Delcros JG; Moulinoux JP
    Eur J Biochem; 1997 Jan; 243(1-2):527-36. PubMed ID: 9030781
    [TBL] [Abstract][Full Text] [Related]  

  • 9. In vitro antitumor properties of a novel cyclin-dependent kinase inhibitor, P276-00.
    Joshi KS; Rathos MJ; Joshi RD; Sivakumar M; Mascarenhas M; Kamble S; Lal B; Sharma S
    Mol Cancer Ther; 2007 Mar; 6(3):918-25. PubMed ID: 17363486
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.
    Chu XJ; DePinto W; Bartkovitz D; So SS; Vu BT; Packman K; Lukacs C; Ding Q; Jiang N; Wang K; Goelzer P; Yin X; Smith MA; Higgins BX; Chen Y; Xiang Q; Moliterni J; Kaplan G; Graves B; Lovey A; Fotouhi N
    J Med Chem; 2006 Nov; 49(22):6549-60. PubMed ID: 17064073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Complexities in the development of cyclin-dependent kinase inhibitor drugs.
    Sausville EA
    Trends Mol Med; 2002; 8(4 Suppl):S32-7. PubMed ID: 11927285
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics.
    Fischer PM; Lane DP
    Curr Med Chem; 2000 Dec; 7(12):1213-45. PubMed ID: 11032968
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs.
    Roskoski R
    Pharmacol Res; 2016 May; 107():249-275. PubMed ID: 26995305
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Imidazo[1,2-a]pyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation.
    Anderson M; Beattie JF; Breault GA; Breed J; Byth KF; Culshaw JD; Ellston RP; Green S; Minshull CA; Norman RA; Pauptit RA; Stanway J; Thomas AP; Jewsbury PJ
    Bioorg Med Chem Lett; 2003 Sep; 13(18):3021-6. PubMed ID: 12941325
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Thio- and oxoflavopiridols, cyclin-dependent kinase 1-selective inhibitors: synthesis and biological effects.
    Kim KS; Sack JS; Tokarski JS; Qian L; Chao ST; Leith L; Kelly YF; Misra RN; Hunt JT; Kimball SD; Humphreys WG; Wautlet BS; Mulheron JG; Webster KR
    J Med Chem; 2000 Nov; 43(22):4126-34. PubMed ID: 11063609
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Complex regulation of CDKs and G1 arrest during the granulocytic differentiation of human myeloblastic leukemia ML-1 cells.
    Shimizu T; Awai N; Takeda K
    Oncogene; 2000 Sep; 19(40):4640-6. PubMed ID: 11030153
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Identification of selective inhibitors of cyclin dependent kinase 4.
    Carini DJ; Kaltenbach RF; Liu J; Benfield PA; Boylan J; Boisclair M; Brizuela L; Burton CR; Cox S; Grafstrom R; Harrison BA; Harrison K; Akamike E; Markwalder JA; Nakano Y; Seitz SP; Sharp DM; Trainor GL; Sielecki TM
    Bioorg Med Chem Lett; 2001 Aug; 11(16):2209-11. PubMed ID: 11514172
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Structure-based design of cyclin-dependent kinase inhibitors.
    Davies TG; Pratt DJ; Endicott JA; Johnson LN; Noble ME
    Pharmacol Ther; 2002; 93(2-3):125-33. PubMed ID: 12191605
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of cdk4 and cdk2 during rat liver regeneration is associated with intranuclear rearrangements of cyclin-cdk complexes.
    Jaumot M; Estanyol JM; Serratosa J; Agell N; Bachs O
    Hepatology; 1999 Feb; 29(2):385-95. PubMed ID: 9918914
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cyclin-dependent kinase inhibitors.
    Fischer PM; Endicott J; Meijer L
    Prog Cell Cycle Res; 2003; 5():235-48. PubMed ID: 14593718
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 24.