223 related articles for article (PubMed ID: 15855531)
1. Inhibitory effect of 2'-substituted nucleosides on hepatitis C virus replication correlates with metabolic properties in replicon cells.
Tomassini JE; Getty K; Stahlhut MW; Shim S; Bhat B; Eldrup AB; Prakash TP; Carroll SS; Flores O; MacCoss M; McMasters DR; Migliaccio G; Olsen DB
Antimicrob Agents Chemother; 2005 May; 49(5):2050-8. PubMed ID: 15855531
[TBL] [Abstract][Full Text] [Related]
2. Anti-hepatitis C virus activity of novel beta-d-2'-C-methyl-4'-azido pyrimidine nucleoside phosphoramidate prodrugs.
Rondla R; Coats SJ; McBrayer TR; Grier J; Johns M; Tharnish PM; Whitaker T; Zhou L; Schinazi RF
Antivir Chem Chemother; 2009 Oct; 20(2):99-106. PubMed ID: 19843980
[TBL] [Abstract][Full Text] [Related]
3. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.
Lam AM; Espiritu C; Bansal S; Micolochick Steuer HM; Zennou V; Otto MJ; Furman PA
J Virol; 2011 Dec; 85(23):12334-42. PubMed ID: 21957306
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication.
Clark JL; Mason JC; Hollecker L; Stuyver LJ; Tharnish PM; McBrayer TR; Otto MJ; Furman PA; Schinazi RF; Watanabe KA
Bioorg Med Chem Lett; 2006 Mar; 16(6):1712-5. PubMed ID: 16368235
[TBL] [Abstract][Full Text] [Related]
5. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine.
Lam AM; Espiritu C; Murakami E; Zennou V; Bansal S; Micolochick Steuer HM; Niu C; Keilman M; Bao H; Bourne N; Veselenak RL; Reddy PG; Chang W; Du J; Nagarathnam D; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2011 Jun; 55(6):2566-75. PubMed ID: 21444700
[TBL] [Abstract][Full Text] [Related]
6. Synthesis of 9-(2-beta-C-methyl-beta-d-ribofuranosyl)-6-substituted purine derivatives as inhibitors of HCV RNA replication.
Ding Y; Girardet JL; Hong Z; Lai VC; An H; Koh YH; Shaw SZ; Zhong W
Bioorg Med Chem Lett; 2005 Feb; 15(3):709-13. PubMed ID: 15664842
[TBL] [Abstract][Full Text] [Related]
7. Cyclic monophosphate prodrugs of base-modified 2'-C-methyl ribonucleosides as potent inhibitors of hepatitis C virus RNA replication.
Gunic E; Girardet JL; Ramasamy K; Stoisavljevic-Petkov V; Chow S; Yeh LT; Hamatake RK; Raney A; Hong Z
Bioorg Med Chem Lett; 2007 May; 17(9):2452-5. PubMed ID: 17331721
[TBL] [Abstract][Full Text] [Related]
8. In vitro selected Con1 subgenomic replicons resistant to 2'-C-methyl-cytidine or to R1479 show lack of cross resistance.
Le Pogam S; Jiang WR; Leveque V; Rajyaguru S; Ma H; Kang H; Jiang S; Singer M; Ali S; Klumpp K; Smith D; Symons J; Cammack N; Nájera I
Virology; 2006 Aug; 351(2):349-59. PubMed ID: 16713611
[TBL] [Abstract][Full Text] [Related]
9. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication.
Lam AM; Murakami E; Espiritu C; Steuer HM; Niu C; Keilman M; Bao H; Zennou V; Bourne N; Julander JG; Morrey JD; Smee DF; Frick DN; Heck JA; Wang P; Nagarathnam D; Ross BS; Sofia MJ; Otto MJ; Furman PA
Antimicrob Agents Chemother; 2010 Aug; 54(8):3187-96. PubMed ID: 20516278
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of hepatitis C virus RNA replication by 2'-modified nucleoside analogs.
Carroll SS; Tomassini JE; Bosserman M; Getty K; Stahlhut MW; Eldrup AB; Bhat B; Hall D; Simcoe AL; LaFemina R; Rutkowski CA; Wolanski B; Yang Z; Migliaccio G; De Francesco R; Kuo LC; MacCoss M; Olsen DB
J Biol Chem; 2003 Apr; 278(14):11979-84. PubMed ID: 12554735
[TBL] [Abstract][Full Text] [Related]
11. In vitro efficacy of approved and experimental antivirals against novel genotype 3 hepatitis C virus subgenomic replicons.
Yu M; Corsa AC; Xu S; Peng B; Gong R; Lee YJ; Chan K; Mo H; Delaney W; Cheng G
Antiviral Res; 2013 Nov; 100(2):439-45. PubMed ID: 24013001
[TBL] [Abstract][Full Text] [Related]
12. Nucleoside analog inhibitors of hepatitis C virus replication.
Carroll SS; Olsen DB
Infect Disord Drug Targets; 2006 Mar; 6(1):17-29. PubMed ID: 16787301
[TBL] [Abstract][Full Text] [Related]
13. Inhibition of hepatitis C replicon RNA synthesis by beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine: a specific inhibitor of hepatitis C virus replication.
Stuyver LJ; McBrayer TR; Tharnish PM; Clark J; Hollecker L; Lostia S; Nachman T; Grier J; Bennett MA; Xie MY; Schinazi RF; Morrey JD; Julander JL; Furman PA; Otto MJ
Antivir Chem Chemother; 2006; 17(2):79-87. PubMed ID: 17042329
[TBL] [Abstract][Full Text] [Related]
14. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.
Feng JY; Cheng G; Perry J; Barauskas O; Xu Y; Fenaux M; Eng S; Tirunagari N; Peng B; Yu M; Tian Y; Lee YJ; Stepan G; Lagpacan LL; Jin D; Hung M; Ku KS; Han B; Kitrinos K; Perron M; Birkus G; Wong KA; Zhong W; Kim CU; Carey A; Cho A; Ray AS
Antimicrob Agents Chemother; 2014; 58(4):1930-42. PubMed ID: 24419349
[TBL] [Abstract][Full Text] [Related]
15. The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture.
Klumpp K; Lévêque V; Le Pogam S; Ma H; Jiang WR; Kang H; Granycome C; Singer M; Laxton C; Hang JQ; Sarma K; Smith DB; Heindl D; Hobbs CJ; Merrett JH; Symons J; Cammack N; Martin JA; Devos R; Nájera I
J Biol Chem; 2006 Feb; 281(7):3793-9. PubMed ID: 16316989
[TBL] [Abstract][Full Text] [Related]
16. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups.
Klumpp K; Kalayanov G; Ma H; Le Pogam S; Leveque V; Jiang WR; Inocencio N; De Witte A; Rajyaguru S; Tai E; Chanda S; Irwin MR; Sund C; Winqist A; Maltseva T; Eriksson S; Usova E; Smith M; Alker A; Najera I; Cammack N; Martin JA; Johansson NG; Smith DB
J Biol Chem; 2008 Jan; 283(4):2167-75. PubMed ID: 18003608
[TBL] [Abstract][Full Text] [Related]
17. A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
Olsen DB; Eldrup AB; Bartholomew L; Bhat B; Bosserman MR; Ceccacci A; Colwell LF; Fay JF; Flores OA; Getty KL; Grobler JA; LaFemina RL; Markel EJ; Migliaccio G; Prhavc M; Stahlhut MW; Tomassini JE; MacCoss M; Hazuda DJ; Carroll SS
Antimicrob Agents Chemother; 2004 Oct; 48(10):3944-53. PubMed ID: 15388457
[TBL] [Abstract][Full Text] [Related]
18. 3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of hepatitis C virus subgenomic replicon and NS5B polymerase activity.
Priet S; Zlatev I; Barvik I; Geerts K; Leyssen P; Neyts J; Dutartre H; Canard B; Vasseur JJ; Morvan F; Alvarez K
J Med Chem; 2010 Sep; 53(18):6608-17. PubMed ID: 20799693
[TBL] [Abstract][Full Text] [Related]
19. Design, synthesis, and antiviral properties of 4'-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479.
Smith DB; Martin JA; Klumpp K; Baker SJ; Blomgren PA; Devos R; Granycome C; Hang J; Hobbs CJ; Jiang WR; Laxton C; Le Pogam S; Leveque V; Ma H; Maile G; Merrett JH; Pichota A; Sarma K; Smith M; Swallow S; Symons J; Vesey D; Najera I; Cammack N
Bioorg Med Chem Lett; 2007 May; 17(9):2570-6. PubMed ID: 17317178
[TBL] [Abstract][Full Text] [Related]
20. The hepatitis C virus replicon presents a higher barrier to resistance to nucleoside analogs than to nonnucleoside polymerase or protease inhibitors.
McCown MF; Rajyaguru S; Le Pogam S; Ali S; Jiang WR; Kang H; Symons J; Cammack N; Najera I
Antimicrob Agents Chemother; 2008 May; 52(5):1604-12. PubMed ID: 18285474
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
