131 related articles for article (PubMed ID: 15857110)
1. Discovery of a beta-MSH-derived MC-4R selective agonist.
Mayer JP; Hsiung HM; Flora DB; Edwards P; Smith DP; Zhang XY; Gadski RA; Heiman ML; Hertel JL; Emmerson PJ; Husain S; O'brien TP; Kahl SD; Smiley DL; Zhang L; Dimarchi RD; Yan LZ
J Med Chem; 2005 May; 48(9):3095-8. PubMed ID: 15857110
[TBL] [Abstract][Full Text] [Related]
2. Novel selective neuropeptide Y2 receptor PEGylated peptide agonists reduce food intake and body weight in mice.
Lumb KJ; DeCarr LB; Milardo LF; Mays MR; Buckholz TM; Fisk SE; Pellegrino CM; Ortiz AA; Mahle CD
J Med Chem; 2007 May; 50(9):2264-8. PubMed ID: 17425299
[TBL] [Abstract][Full Text] [Related]
3. 1H-NMR studies on a potent and selective antagonist at human melanocortin receptor 4 (hMC-4R).
Victoria Silva Elipe M; Mosley RT; Bednarek MA; Arison BH
Biopolymers; 2003 Apr; 68(4):512-27. PubMed ID: 12666176
[TBL] [Abstract][Full Text] [Related]
4. Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity.
Nargund RP; Strack AM; Fong TM
J Med Chem; 2006 Jul; 49(14):4035-43. PubMed ID: 16821763
[No Abstract] [Full Text] [Related]
5. Identification and in vivo and in vitro characterization of long acting and melanocortin 4 receptor (MC4-R) selective α-melanocyte-stimulating hormone (α-MSH) analogues.
Conde-Frieboes K; Thøgersen H; Lau JF; Sensfuss U; Hansen TK; Christensen L; Spetzler J; Olsen HB; Nilsson C; Raun K; Dahl K; Hansen BS; Wulff BS
J Med Chem; 2012 Mar; 55(5):1969-77. PubMed ID: 22335602
[TBL] [Abstract][Full Text] [Related]
6. Interactions of amylinergic and melanocortinergic systems in the control of food intake and body weight in rodents.
Roth JD; D'Souza L; Griffin PS; Athanacio J; Trevaskis JL; Nazarbaghi R; Jodka C; Athanacio J; Hoyt J; Forood B; Parkes DG
Diabetes Obes Metab; 2012 Jul; 14(7):608-15. PubMed ID: 22276636
[TBL] [Abstract][Full Text] [Related]
7. Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity.
Hess S; Linde Y; Ovadia O; Safrai E; Shalev DE; Swed A; Halbfinger E; Lapidot T; Winkler I; Gabinet Y; Faier A; Yarden D; Xiang Z; Portillo FP; Haskell-Luevano C; Gilon C; Hoffman A
J Med Chem; 2008 Feb; 51(4):1026-34. PubMed ID: 18220330
[TBL] [Abstract][Full Text] [Related]
8. Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
Yan L; Huo P; Debenham JS; Madsen-Duggan CB; Lao J; Chen RZ; Xiao JC; Shen CP; Stribling DS; Shearman LP; Strack AM; Tsou N; Ball RG; Wang J; Tong X; Bateman TJ; Reddy VB; Fong TM; Hale JJ
J Med Chem; 2010 May; 53(10):4028-37. PubMed ID: 20423086
[TBL] [Abstract][Full Text] [Related]
9. Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation.
Muceniece R; Zvejniece L; Vilskersts R; Liepinsh E; Baumane L; Kalvinsh I; Wikberg JE; Dambrova M
Basic Clin Pharmacol Toxicol; 2007 Dec; 101(6):416-20. PubMed ID: 18028105
[TBL] [Abstract][Full Text] [Related]
10. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.
Vachal P; Fletcher JM; Fong TM; Huang CC; Lao J; Xiao JC; Shen CP; Strack AM; Shearman L; Stribling S; Chen RZ; Frassetto A; Tong X; Wang J; Ball RG; Tsou NN; Hickey GJ; Thompson DF; Faidley TD; Nicolich S; Achanfuo-Yeboah J; Hora DF; Hale JJ; Hagmann WK
J Med Chem; 2009 Apr; 52(8):2550-8. PubMed ID: 19320488
[TBL] [Abstract][Full Text] [Related]
11. Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold.
Yan LZ; Flora D; Edwards P; Smiley DL; Emmerson PJ; Hsiung HM; Gadski R; Hertel J; Heiman ML; Husain S; O'Brien TP; Kahl SD; Zhang L; Dimarchi RD; Mayer JP
Bioorg Med Chem Lett; 2005 Oct; 15(20):4611-4. PubMed ID: 16105738
[TBL] [Abstract][Full Text] [Related]
12. Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas.
McBriar MD; Guzik H; Shapiro S; Paruchova J; Xu R; Palani A; Clader JW; Cox K; Greenlee WJ; Hawes BE; Kowalski TJ; O'neill K; Spar BD; Weig B; Weston DJ; Farley C; Cook J
J Med Chem; 2006 Apr; 49(7):2294-310. PubMed ID: 16570926
[TBL] [Abstract][Full Text] [Related]
13. Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV.
Hsiung HM; Smiley DL; Zhang XY; Zhang L; Yan LZ; Craft L; Heiman ML; Smith DP
Peptides; 2005 Oct; 26(10):1988-96. PubMed ID: 15985311
[TBL] [Abstract][Full Text] [Related]
14. New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.
Moulin A; Demange L; Ryan J; Mousseaux D; Sanchez P; Bergé G; Gagne D; Perrissoud D; Locatelli V; Torsello A; Galleyrand JC; Fehrentz JA; Martinez J
J Med Chem; 2008 Feb; 51(3):689-93. PubMed ID: 18193826
[TBL] [Abstract][Full Text] [Related]
15. Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Lin LS; Lanza TJ; Jewell JP; Liu P; Shah SK; Qi H; Tong X; Wang J; Xu SS; Fong TM; Shen CP; Lao J; Xiao JC; Shearman LP; Stribling DS; Rosko K; Strack A; Marsh DJ; Feng Y; Kumar S; Samuel K; Yin W; Van der Ploeg LH; Goulet MT; Hagmann WK
J Med Chem; 2006 Dec; 49(26):7584-7. PubMed ID: 17181138
[TBL] [Abstract][Full Text] [Related]
16. N-terminal fatty acylated His-dPhe-Arg-Trp-NH(2) tetrapeptides: influence of fatty acid chain length on potency and selectivity at the mouse melanocortin receptors and human melanocytes.
Todorovic A; Holder JR; Bauzo RM; Scott JW; Kavanagh R; Abdel-Malek Z; Haskell-Luevano C
J Med Chem; 2005 May; 48(9):3328-36. PubMed ID: 15857138
[TBL] [Abstract][Full Text] [Related]
17. Discovery of orally bioavailable 1,3,4-trisubstituted 2-oxopiperazine-based melanocortin-4 receptor agonists as potential antiobesity agents.
Tian X; Switzer AG; Derose SA; Mishra RK; Solinsky MG; Mumin RN; Ebetino FH; Jayasinghe LR; Webster ME; Colson AO; Crossdoersen D; Pinney BB; Farmer JA; Dowty ME; Obringer CM; Cruze CA; Burklow ML; Suchanek PM; Dong L; Dirr MK; Sheldon RJ; Wos JA
J Med Chem; 2008 Oct; 51(19):6055-66. PubMed ID: 18771254
[TBL] [Abstract][Full Text] [Related]
18. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity.
Smith BM; Smith JM; Tsai JH; Schultz JA; Gilson CA; Estrada SA; Chen RR; Park DM; Prieto EB; Gallardo CS; Sengupta D; Dosa PI; Covel JA; Ren A; Webb RR; Beeley NR; Martin M; Morgan M; Espitia S; Saldana HR; Bjenning C; Whelan KT; Grottick AJ; Menzaghi F; Thomsen WJ
J Med Chem; 2008 Jan; 51(2):305-13. PubMed ID: 18095642
[TBL] [Abstract][Full Text] [Related]
19. Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents.
Fong TM; Guan XM; Marsh DJ; Shen CP; Stribling DS; Rosko KM; Lao J; Yu H; Feng Y; Xiao JC; Van der Ploeg LH; Goulet MT; Hagmann WK; Lin LS; Lanza TJ; Jewell JP; Liu P; Shah SK; Qi H; Tong X; Wang J; Xu SS; Francis B; Strack AM; MacIntyre DE; Shearman LP
J Pharmacol Exp Ther; 2007 Jun; 321(3):1013-22. PubMed ID: 17327489
[TBL] [Abstract][Full Text] [Related]
20. A novel and selective beta-melanocyte-stimulating hormone-derived peptide agonist for melanocortin 4 receptor potently decreased food intake and body weight gain in diet-induced obese rats.
Hsiung HM; Hertel J; Zhang XY; Smith DP; Smiley DL; Heiman ML; Yang DD; Husain S; Mayer JP; Zhang L; Mo H; Yan LZ
Endocrinology; 2005 Dec; 146(12):5257-66. PubMed ID: 16166226
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
