BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 15857129)

  • 1. On the binding of indeno[1,2-c]isoquinolines in the DNA-topoisomerase I cleavage complex.
    Xiao X; Antony S; Pommier Y; Cushman M
    J Med Chem; 2005 May; 48(9):3231-8. PubMed ID: 15857129
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex.
    Staker BL; Feese MD; Cushman M; Pommier Y; Zembower D; Stewart L; Burgin AB
    J Med Chem; 2005 Apr; 48(7):2336-45. PubMed ID: 15801827
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.
    Nagarajan M; Morrell A; Fort BC; Meckley MR; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2004 Nov; 47(23):5651-61. PubMed ID: 15509164
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.
    Fox BM; Xiao X; Antony S; Kohlhagen G; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2003 Jul; 46(15):3275-82. PubMed ID: 12852757
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.
    Nagarajan M; Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2003 Dec; 46(26):5712-24. PubMed ID: 14667224
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.
    Strumberg D; Pommier Y; Paull K; Jayaraman M; Nagafuji P; Cushman M
    J Med Chem; 1999 Feb; 42(3):446-57. PubMed ID: 9986716
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.
    Antony S; Jayaraman M; Laco G; Kohlhagen G; Kohn KW; Cushman M; Pommier Y
    Cancer Res; 2003 Nov; 63(21):7428-35. PubMed ID: 14612542
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Molecular modeling studies of the DNA-topoisomerase I ternary cleavable complex with camptothecin.
    Fan Y; Weinstein JN; Kohn KW; Shi LM; Pommier Y
    J Med Chem; 1998 Jun; 41(13):2216-26. PubMed ID: 9632354
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The binding orientation of a norindenoisoquinoline in the topoisomerase I-DNA cleavage complex is primarily governed by pi-pi stacking interactions.
    Song Y; Cushman M
    J Phys Chem B; 2008 Aug; 112(31):9484-9. PubMed ID: 18636761
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Persistence of camptothecin analog-topoisomerase I-DNA ternary complexes: a molecular dynamics study.
    Siu FM; Che CM
    J Am Chem Soc; 2008 Dec; 130(52):17928-37. PubMed ID: 19035632
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis.
    Ioanoviciu A; Antony S; Pommier Y; Staker BL; Stewart L; Cushman M
    J Med Chem; 2005 Jul; 48(15):4803-14. PubMed ID: 16033260
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay.
    Morrell A; Jayaraman M; Nagarajan M; Fox BM; Meckley MR; Ioanoviciu A; Pommier Y; Antony S; Hollingshead M; Cushman M
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4395-9. PubMed ID: 16750365
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors.
    Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    Bioorg Med Chem; 2004 Oct; 12(19):5147-60. PubMed ID: 15351398
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Electrostatic factors in DNA intercalation.
    Medhi C; Mitchell JB; Price SL; Tabor AB
    Biopolymers; 1999; 52(2):84-93. PubMed ID: 10898854
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Bisindenoisoquinoline bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA intercalator and topoisomerase inhibitor with antitumor activity.
    Antony S; Agama KK; Miao ZH; Hollingshead M; Holbeck SL; Wright MH; Varticovski L; Nagarajan M; Morrell A; Cushman M; Pommier Y
    Mol Pharmacol; 2006 Sep; 70(3):1109-20. PubMed ID: 16798938
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A systematic study of nitrated indenoisoquinolines reveals a potent topoisomerase I inhibitor.
    Morrell A; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Med Chem; 2006 Dec; 49(26):7740-53. PubMed ID: 17181156
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.
    Cushman M; Jayaraman M; Vroman JA; Fukunaga AK; Fox BM; Kohlhagen G; Strumberg D; Pommier Y
    J Med Chem; 2000 Oct; 43(20):3688-98. PubMed ID: 11020283
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel autoxidative cleavage reaction of 9-fluoredenes discovered during synthesis of a potential DNA-threading indenoisoquinoline.
    Xiao X; Antony S; Kohlhagen G; Pommier Y; Cushman M
    J Org Chem; 2004 Oct; 69(22):7495-501. PubMed ID: 15497974
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Nitrated indenoisoquinolines as topoisomerase I inhibitors: a systematic study and optimization.
    Morrell A; Placzek M; Parmley S; Antony S; Dexheimer TS; Pommier Y; Cushman M
    J Med Chem; 2007 Sep; 50(18):4419-30. PubMed ID: 17696418
    [TBL] [Abstract][Full Text] [Related]  

  • 20. An ab initio quantum mechanics calculation that correlates with ligand orientation and DNA cleavage site selectivity in camptothecin-DNA-topoisomerase I ternary cleavage complexes.
    Xiao X; Cushman M
    J Am Chem Soc; 2005 Jul; 127(28):9960-1. PubMed ID: 16011334
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.