174 related articles for article (PubMed ID: 15863327)
1. 5-Lipoxygenase inhibitors: convenient synthesis of 4-[3-(4-heterocyclylphenylthio)phenyl]-3,4,5,6-tetrahydro-2H-pyran-4-carboxamide analogues.
Mano T; Stevens RW; Okumura Y; Kawai M; Okumura T; Sakakibara M
Bioorg Med Chem Lett; 2005 May; 15(10):2611-5. PubMed ID: 15863327
[TBL] [Abstract][Full Text] [Related]
2. 4-[5-Fluoro-3-[4-(2-methyl-1H-imidazol-1-yl)benzyloxy]phenyl]-3,4,5,6- tetrahydro-2H-pyran-4-carboxamide, an orally active inhibitor of 5-lipoxygenase with improved pharmacokinetic and toxicology characteristics.
Mano T; Okumura Y; Sakakibara M; Okumura T; Tamura T; Miyamoto K; Stevens RW
J Med Chem; 2004 Jan; 47(3):720-5. PubMed ID: 14736252
[TBL] [Abstract][Full Text] [Related]
3. 5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.
Bhatia PA; Brooks CD; Basha A; Ratajczyk JD; Gunn BP; Bouska JB; Lanni C; Young PR; Bell RL; Carter GW
J Med Chem; 1996 Sep; 39(20):3938-50. PubMed ID: 8831760
[TBL] [Abstract][Full Text] [Related]
4. Structure and activity relationships leading to the discovery of ICI D2138, a selective, potent and orally active inhibitor of 5-lipoxygenase.
Crawley GC; Bird TG; Bruneau P; Dowell RI; Edwards PN; Foster SJ; Girodeau JM; McMillan RM; Walker ER; Waterson D
J Lipid Mediat; 1993; 6(1-3):249-57. PubMed ID: 8395247
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
Doiron J; Boudreau LH; Picot N; Villebonet B; Surette ME; Touaibia M
Bioorg Med Chem Lett; 2009 Feb; 19(4):1118-21. PubMed ID: 19152786
[TBL] [Abstract][Full Text] [Related]
6. Synthesis and biological evaluation of a novel class of rofecoxib analogues as dual inhibitors of cyclooxygenases (COXs) and lipoxygenases (LOXs).
Chen QH; Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7898-909. PubMed ID: 16904331
[TBL] [Abstract][Full Text] [Related]
7. 6-substituted purines as inhibitors of 15-lipoxygenase; a structure-activity study.
Bråthe A; Gundersen LL; Malterud KE; Rise F
Arch Pharm (Weinheim); 2005 Apr; 338(4):159-66. PubMed ID: 15864785
[TBL] [Abstract][Full Text] [Related]
8. Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
Delorme D; Ducharme Y; Brideau C; Chan CC; Chauret N; Desmarais S; Dubé D; Falgueyret JP; Fortin R; Guay J; Hamel P; Jones TR; Lépine C; Li C; McAuliffe M; McFarlane CS; Nicoll-Griffith DA; Riendeau D; Yergey JA; Girard Y
J Med Chem; 1996 Sep; 39(20):3951-70. PubMed ID: 8831761
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.
Barzen S; Rödl CB; Lill A; Steinhilber D; Stark H; Hofmann B
Bioorg Med Chem; 2012 Jun; 20(11):3575-83. PubMed ID: 22551629
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and biological evaluation of (E)-3-(4-methanesulfonylphenyl)-2-(aryl)acrylic acids as dual inhibitors of cyclooxygenases and lipoxygenases.
Moreau A; Chen QH; Praveen Rao PN; Knaus EE
Bioorg Med Chem; 2006 Dec; 14(23):7716-27. PubMed ID: 16931030
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of celecoxib analogues possessing a N-difluoromethyl-1,2-dihydropyrid-2-one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Chowdhury MA; Abdellatif KR; Dong Y; Das D; Suresh MR; Knaus EE
J Med Chem; 2009 Mar; 52(6):1525-9. PubMed ID: 19296694
[TBL] [Abstract][Full Text] [Related]
12. Optimization of imidazole 5-lipoxygenase inhibitors and selection and synthesis of a development candidate.
Mano T; Stevens RW; Ando K; Kawai M; Kawamura K; Nakao K; Okumura Y; Okumura T; Sakakibara M; Miyamoto K; Tamura T
Chem Pharm Bull (Tokyo); 2005 Aug; 53(8):965-73. PubMed ID: 16079529
[TBL] [Abstract][Full Text] [Related]
13. A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors.
Hofmann B; Barzen S; Rödl CB; Kiehl A; Borig J; Zivković A; Stark H; Schneider G; Steinhilber D
J Med Chem; 2011 Mar; 54(6):1943-7. PubMed ID: 21341744
[TBL] [Abstract][Full Text] [Related]
14. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters.
Zhang S; Fernandez F; Hazeldine S; Deschamps J; Zhen J; Reith ME; Dutta AK
J Med Chem; 2006 Jul; 49(14):4239-47. PubMed ID: 16821783
[TBL] [Abstract][Full Text] [Related]
15. Caulerpenyne and related bis-enol esters are novel-type inhibitors of human 5-lipoxygenase.
Richter P; Schubert G; Schaible AM; Cavas L; Werz O; Pohnert G
ChemMedChem; 2014 Aug; 9(8):1655-9. PubMed ID: 24729578
[TBL] [Abstract][Full Text] [Related]
16. SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.
Hieke M; Rödl CB; Wisniewska JM; la Buscató E; Stark H; Schubert-Zsilavecz M; Steinhilber D; Hofmann B; Proschak E
Bioorg Med Chem Lett; 2012 Mar; 22(5):1969-75. PubMed ID: 22326163
[TBL] [Abstract][Full Text] [Related]
17. Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase.
Mano T; Stevens RW; Ando K; Nakao K; Okumura Y; Sakakibara M; Okumura T; Tamura T; Miyamoto K
Bioorg Med Chem; 2003 Sep; 11(18):3879-87. PubMed ID: 12927848
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of new sulfonamides as lipoxygenase inhibitors.
Mustafa G; Khan IU; Ashraf M; Afzal I; Shahzad SA; Shafiq M
Bioorg Med Chem; 2012 Apr; 20(8):2535-9. PubMed ID: 22436389
[TBL] [Abstract][Full Text] [Related]
19. Lipoxygenase inhibitors from natural plant sources. Part 1: Medicinal plants with inhibitory activity on arachidonate 5-lipoxygenase and 5-lipoxygenase[sol ]cyclooxygenase.
Schneider I; Bucar F
Phytother Res; 2005 Feb; 19(2):81-102. PubMed ID: 15852496
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors.
Bakavoli M; Nikpour M; Rahimizadeh M; Saberi MR; Sadeghian H
Bioorg Med Chem; 2007 Mar; 15(5):2120-6. PubMed ID: 17210254
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]