These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

171 related articles for article (PubMed ID: 15863342)

  • 1. Aryl sulfones: a new class of gamma-secretase inhibitors.
    Teall M; Oakley P; Harrison T; Shaw D; Kay E; Elliott J; Gerhard U; Castro JL; Shearman M; Ball RG; Tsou NN
    Bioorg Med Chem Lett; 2005 May; 15(10):2685-8. PubMed ID: 15863342
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 3-Substituted gem-cyclohexane sulfone based gamma-secretase inhibitors for Alzheimer's disease: conformational analysis and biological activity.
    Jelley RA; Elliott J; Gibson KR; Harrison T; Beher D; Clarke EE; Lewis HD; Shearman M; Wrigley JD
    Bioorg Med Chem Lett; 2006 Jul; 16(14):3839-42. PubMed ID: 16682202
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 4-substituted cyclohexyl sulfones as potent, orally active gamma-secretase inhibitors.
    Churcher I; Beher D; Best JD; Castro JL; Clarke EE; Gentry A; Harrison T; Hitzel L; Kay E; Kerrad S; Lewis HD; Morentin-Gutierrez P; Mortishire-Smith R; Oakley PJ; Reilly M; Shaw DE; Shearman MS; Teall MR; Williams S; Wrigley JD
    Bioorg Med Chem Lett; 2006 Jan; 16(2):280-4. PubMed ID: 16275079
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 3,4-Fused cyclohexyl sulfones as gamma-secretase inhibitors.
    Shaw D; Best J; Dinnell K; Nadin A; Shearman M; Pattison C; Peachey J; Reilly M; Williams B; Wrigley J; Harrison T
    Bioorg Med Chem Lett; 2006 Jun; 16(11):3073-7. PubMed ID: 16617016
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alzheimer's disease. A firm base for drug development.
    De Strooper B; König G
    Nature; 1999 Dec; 402(6761):471-2. PubMed ID: 10591201
    [No Abstract]   [Full Text] [Related]  

  • 6. The potential for BACE1 inhibitors in the treatment of Alzheimer's disease.
    Hussain I
    IDrugs; 2004 Jul; 7(7):653-8. PubMed ID: 15243867
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge.
    Citron M
    Trends Pharmacol Sci; 2004 Feb; 25(2):92-7. PubMed ID: 15102495
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors.
    Thompson LA; Liauw AY; Ramanjulu MM; Kasireddy-Polam P; Mercer SE; Maduskuie TP; Glicksman M; Roach AH; Meredith JE; Liu RQ; Combs AP; Higaki JN; Cordell B; Seiffert D; Zaczek RC; Robertson DW; Olson RE
    Bioorg Med Chem Lett; 2006 May; 16(9):2357-63. PubMed ID: 16473009
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
    Hussain I; Hawkins J; Harrison D; Hille C; Wayne G; Cutler L; Buck T; Walter D; Demont E; Howes C; Naylor A; Jeffrey P; Gonzalez MI; Dingwall C; Michel A; Redshaw S; Davis JB
    J Neurochem; 2007 Feb; 100(3):802-9. PubMed ID: 17156133
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tracking Alzheimer's.
    Roberts L
    US News World Rep; 1999 Nov; 127(17):73. PubMed ID: 10623301
    [No Abstract]   [Full Text] [Related]  

  • 11. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
    Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
    J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.
    Holsinger RM; McLean CA; Collins SJ; Masters CL; Evin G
    Ann Neurol; 2004 Jun; 55(6):898-9. PubMed ID: 15174031
    [No Abstract]   [Full Text] [Related]  

  • 13. Novel heparan sulphate analogues: inhibition of beta-secretase cleavage of amyloid precursor protein.
    Patey SJ; Yates EA; Turnbull JE
    Biochem Soc Trans; 2005 Nov; 33(Pt 5):1116-8. PubMed ID: 16246059
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Progress toward the discovery and development of efficacious BACE inhibitors.
    Durham TB; Shepherd TA
    Curr Opin Drug Discov Devel; 2006 Nov; 9(6):776-91. PubMed ID: 17117686
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The potential of BACE inhibitors for Alzheimer's therapy.
    Potter H; Dressler D
    Nat Biotechnol; 2000 Feb; 18(2):125-6. PubMed ID: 10657070
    [No Abstract]   [Full Text] [Related]  

  • 16. Progress toward a practical BACE-1 inhibitor.
    Hills ID; Vacca JP
    Curr Opin Drug Discov Devel; 2007 Jul; 10(4):383-91. PubMed ID: 17659479
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A beta-secretase (BACE1) inhibitor hispidin from the mycelial cultures of Phellinus linteus.
    Park IH; Jeon SY; Lee HJ; Kim SI; Song KS
    Planta Med; 2004 Feb; 70(2):143-6. PubMed ID: 14994192
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.
    Vingtdeux V; Hamdane M; Gompel M; Bégard S; Drobecq H; Ghestem A; Grosjean ME; Kostanjevecki V; Grognet P; Vanmechelen E; Buée L; Delacourte A; Sergeant N
    Neurobiol Dis; 2005 Nov; 20(2):625-37. PubMed ID: 15936948
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Carbazole-containing arylcarboxamides as BACE1 inhibitors.
    Bertini S; Asso V; Ghilardi E; Granchi C; Manera C; Minutolo F; Saccomanni G; Bortolato A; Mason J; Moro S; Macchia M
    Bioorg Med Chem Lett; 2011 Nov; 21(22):6657-61. PubMed ID: 21986588
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Effects of a gamma-secretase inhibitor in a randomized study of patients with Alzheimer disease.
    Siemers ER; Quinn JF; Kaye J; Farlow MR; Porsteinsson A; Tariot P; Zoulnouni P; Galvin JE; Holtzman DM; Knopman DS; Satterwhite J; Gonzales C; Dean RA; May PC
    Neurology; 2006 Feb; 66(4):602-4. PubMed ID: 16505324
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.