These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 15869287)

  • 1. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.
    Petrassi HM; Johnson SM; Purkey HE; Chiang KP; Walkup T; Jiang X; Powers ET; Kelly JW
    J Am Chem Soc; 2005 May; 127(18):6662-71. PubMed ID: 15869287
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.
    Green NS; Palaninathan SK; Sacchettini JC; Kelly JW
    J Am Chem Soc; 2003 Nov; 125(44):13404-14. PubMed ID: 14583036
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetic stabilization of an oligomeric protein by a single ligand binding event.
    Wiseman RL; Johnson SM; Kelker MS; Foss T; Wilson IA; Kelly JW
    J Am Chem Soc; 2005 Apr; 127(15):5540-51. PubMed ID: 15826192
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
    Adamski-Werner SL; Palaninathan SK; Sacchettini JC; Kelly JW
    J Med Chem; 2004 Jan; 47(2):355-74. PubMed ID: 14711308
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.
    Wiseman RL; Green NS; Kelly JW
    Biochemistry; 2005 Jun; 44(25):9265-74. PubMed ID: 15966751
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.
    Foss TR; Kelker MS; Wiseman RL; Wilson IA; Kelly JW
    J Mol Biol; 2005 Apr; 347(4):841-54. PubMed ID: 15769474
    [TBL] [Abstract][Full Text] [Related]  

  • 7. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression.
    Sekijima Y; Dendle MT; Wiseman RL; White JT; D'Haeze W; Kelly JW
    Amyloid; 2006 Jun; 13(2):57-66. PubMed ID: 16911959
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.
    Johnson SM; Wiseman RL; Sekijima Y; Green NS; Adamski-Werner SL; Kelly JW
    Acc Chem Res; 2005 Dec; 38(12):911-21. PubMed ID: 16359163
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
    Johnson SM; Petrassi HM; Palaninathan SK; Mohamedmohaideen NN; Purkey HE; Nichols C; Chiang KP; Walkup T; Sacchettini JC; Sharpless KB; Kelly JW
    J Med Chem; 2005 Mar; 48(5):1576-87. PubMed ID: 15743199
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.
    Purkey HE; Palaninathan SK; Kent KC; Smith C; Safe SH; Sacchettini JC; Kelly JW
    Chem Biol; 2004 Dec; 11(12):1719-28. PubMed ID: 15610856
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis.
    Sekijima Y; Dendle MA; Kelly JW
    Amyloid; 2006 Dec; 13(4):236-49. PubMed ID: 17107884
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The pathway by which the tetrameric protein transthyretin dissociates.
    Foss TR; Wiseman RL; Kelly JW
    Biochemistry; 2005 Nov; 44(47):15525-33. PubMed ID: 16300401
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Specific disruption of transthyretin(105-115) fibrilization using "stabilizing" inhibitors of transthyretin amyloidogenesis.
    Liang Y; Ore MO; Morin S; Wilson DJ
    Biochemistry; 2012 Apr; 51(16):3523-30. PubMed ID: 22482799
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.
    Choi S; Reixach N; Connelly S; Johnson SM; Wilson IA; Kelly JW
    J Am Chem Soc; 2010 Feb; 132(4):1359-70. PubMed ID: 20043671
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis.
    Green NS; Foss TR; Kelly JW
    Proc Natl Acad Sci U S A; 2005 Oct; 102(41):14545-50. PubMed ID: 16195386
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Prevention of transthyretin amyloid disease by changing protein misfolding energetics.
    Hammarström P; Wiseman RL; Powers ET; Kelly JW
    Science; 2003 Jan; 299(5607):713-6. PubMed ID: 12560553
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amyloid disease prevention by transthyretin native state complexation with carborane derivatives lacking cyclooxygenase inhibition.
    Julius RL; Hawthorne MF
    Drug News Perspect; 2008 Jun; 21(5):258-66. PubMed ID: 18596990
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors.
    Razavi H; Powers ET; Purkey HE; Adamski-Werner SL; Chiang KP; Dendle MT; Kelly JW
    Bioorg Med Chem Lett; 2005 Feb; 15(4):1075-8. PubMed ID: 15686915
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization.
    Hurshman AR; White JT; Powers ET; Kelly JW
    Biochemistry; 2004 Jun; 43(23):7365-81. PubMed ID: 15182180
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.
    Connelly S; Mortenson DE; Choi S; Wilson IA; Powers ET; Kelly JW; Johnson SM
    Bioorg Med Chem Lett; 2017 Aug; 27(15):3441-3449. PubMed ID: 28625364
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.