BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

188 related articles for article (PubMed ID: 15892579)

  • 1. Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.
    Baer BR; Rettie AE; Henne KR
    Chem Res Toxicol; 2005 May; 18(5):855-64. PubMed ID: 15892579
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Activity Relationships for CYP4B1 Bioactivation of 4-Ipomeanol Congeners: Direct Correlation between Cytotoxicity and Trapped Reactive Intermediates.
    Kowalski JP; McDonald MG; Whittington D; Guttman M; Scian M; Girhard M; Hanenberg H; Wiek C; Rettie AE
    Chem Res Toxicol; 2019 Dec; 32(12):2488-2498. PubMed ID: 31799839
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Generation and characterization of a Cyp4b1 null mouse and the role of CYP4B1 in the activation and toxicity of Ipomeanol.
    Parkinson OT; Liggitt HD; Rettie AE; Kelly EJ
    Toxicol Sci; 2013 Aug; 134(2):243-50. PubMed ID: 23748241
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P; Dalvie D; Smith E; Zhou S; Deese A; Nieman JA
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol.
    Wiek C; Schmidt EM; Roellecke K; Freund M; Nakano M; Kelly EJ; Kaisers W; Yarov-Yarovoy V; Kramm CM; Rettie AE; Hanenberg H
    Biochem J; 2015 Jan; 465(1):103-14. PubMed ID: 25247810
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Metabolism of furans in vitro: ipomeanine and 4-ipomeanol.
    Chen LJ; DeRose EF; Burka LT
    Chem Res Toxicol; 2006 Oct; 19(10):1320-9. PubMed ID: 17040101
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioactivation of phencyclidine in rat and human liver microsomes and recombinant P450 2B enzymes: evidence for the formation of a novel quinone methide intermediate.
    Driscoll JP; Kornecki K; Wolkowski JP; Chupak L; Kalgutkar AS; O'Donnell JP
    Chem Res Toxicol; 2007 Oct; 20(10):1488-97. PubMed ID: 17892269
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Detection of glutathione conjugates derived from 4-ipomeanol metabolism in bile of rats by liquid chromatography-tandem mass spectrometry.
    Alvarez-Diez TM; Zheng J
    Drug Metab Dispos; 2004 Dec; 32(12):1345-50. PubMed ID: 15328249
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Bioactivation of isothiazoles: minimizing the risk of potential toxicity in drug discovery.
    Teffera Y; Choquette D; Liu J; Colletti AE; Hollis LS; Lin MH; Zhao Z
    Chem Res Toxicol; 2010 Nov; 23(11):1743-52. PubMed ID: 20825217
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.
    Chen LJ; Hecht SS; Peterson LA
    Chem Res Toxicol; 1997 Aug; 10(8):866-74. PubMed ID: 9282835
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Selective pathways for the metabolism of phencyclidine by cytochrome p450 2b enzymes: identification of electrophilic metabolites, glutathione, and N-acetyl cysteine adducts.
    Shebley M; Jushchyshyn MI; Hollenberg PF
    Drug Metab Dispos; 2006 Mar; 34(3):375-83. PubMed ID: 16326815
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Elevated susceptibility to 4-ipomeanol cytotoxicity in immature Clara cells of neonatal rabbits.
    Plopper CG; Weir AJ; Nishio SJ; Chang A; Voit M; Philpot RM; Buckpitt AR
    J Pharmacol Exp Ther; 1994 May; 269(2):867-80. PubMed ID: 8182556
    [TBL] [Abstract][Full Text] [Related]  

  • 13. In vitro metabolic activation of the pulmonary toxin, 4-ipomeanol, in nonciliated bronchiolar epithelial (Clara) and alveolar type II cells isolated from rabbit lung.
    Devereux TR; Jones KG; Bend JR; Fouts JR; Statham CN; Boyd MR
    J Pharmacol Exp Ther; 1982 Jan; 220(1):223-7. PubMed ID: 7053419
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Rabbit cytochrome P450 4B1: A novel prodrug activating gene for pharmacogene therapy of hepatocellular carcinoma.
    Mohr L; Rainov NG; Mohr UG; Wands JR
    Cancer Gene Ther; 2000 Jul; 7(7):1008-14. PubMed ID: 10917203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Combined radiation and cytochrome CYP4B1/4-ipomeanol gene therapy using the EGR1 promoter.
    Hsu H; Rainov NG; Quinones A; Eling DJ; Sakamoto KM; Spear MA
    Anticancer Res; 2003; 23(3B):2723-8. PubMed ID: 12894565
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles.
    Anderson WB; Board PG; Anders MW
    Chem Res Toxicol; 2004 May; 17(5):650-62. PubMed ID: 15144222
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Species Differences in Microsomal Oxidation and Glucuronidation of 4-Ipomeanol: Relationship to Target Organ Toxicity.
    Parkinson OT; Teitelbaum AM; Whittington D; Kelly EJ; Rettie AE
    Drug Metab Dispos; 2016 Oct; 44(10):1598-602. PubMed ID: 27468999
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Influence of Stereochemistry on the Bioactivation and Glucuronidation of 4-Ipomeanol.
    Teitelbaum AM; McDonald MG; Kowalski JP; Parkinson OT; Scian M; Whittington D; Roellecke K; Hanenberg H; Wiek C; Rettie AE
    J Pharmacol Exp Ther; 2019 Feb; 368(2):308-316. PubMed ID: 30409834
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s.
    Wen B; Ma L; Zhu M
    Chem Biol Interact; 2008 May; 173(1):59-67. PubMed ID: 18359012
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of a meander region proline residue critical for heme binding to cytochrome P450: implications for the catalytic function of human CYP4B1.
    Zheng YM; Fisher MB; Yokotani N; Fujii-Kuriyama Y; Rettie AE
    Biochemistry; 1998 Sep; 37(37):12847-51. PubMed ID: 9737862
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.