245 related articles for article (PubMed ID: 15917906)
1. Radical properties governing the hypoxia-selective cytotoxicity of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
Org Biomol Chem; 2005 Jun; 3(11):2167-74. PubMed ID: 15917906
[TBL] [Abstract][Full Text] [Related]
2. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
Shinde SS; Anderson RF; Hay MP; Gamage SA; Denny WA
J Am Chem Soc; 2004 Jun; 126(25):7865-74. PubMed ID: 15212534
[TBL] [Abstract][Full Text] [Related]
3. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
Anderson RF; Shinde SS; Hay MP; Denny WA
J Am Chem Soc; 2006 Jan; 128(1):245-9. PubMed ID: 16390153
[TBL] [Abstract][Full Text] [Related]
4. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
Anderson RF; Shinde SS; Hay MP; Gamage SA; Denny WA
J Am Chem Soc; 2003 Jan; 125(3):748-56. PubMed ID: 12526674
[TBL] [Abstract][Full Text] [Related]
5. Structure-activity relationships of 1,2,4-benzotriazine 1,4-dioxides as hypoxia-selective analogues of tirapazamine.
Hay MP; Gamage SA; Kovacs MS; Pruijn FB; Anderson RF; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2003 Jan; 46(1):169-82. PubMed ID: 12502371
[TBL] [Abstract][Full Text] [Related]
6. DNA-targeted 1,2,4-benzotriazine 1,4-dioxides: potent analogues of the hypoxia-selective cytotoxin tirapazamine.
Hay MP; Pruijn FB; Gamage SA; Liyanage HD; Kovacs MS; Patterson AV; Wilson WR; Brown JM; Denny WA
J Med Chem; 2004 Jan; 47(2):475-88. PubMed ID: 14711317
[TBL] [Abstract][Full Text] [Related]
7. Characterization of radicals formed following enzymatic reduction of 3-substituted analogues of the hypoxia-selective cytotoxin 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Shinde SS; Maroz A; Hay MP; Patterson AV; Denny WA; Anderson RF
J Am Chem Soc; 2010 Mar; 132(8):2591-9. PubMed ID: 20141134
[TBL] [Abstract][Full Text] [Related]
8. Microsomal reduction of 3-amino-1,2,4-benzotriazine 1,4-dioxide to a free radical.
Lloyd RV; Duling DR; Rumyantseva GV; Mason RP; Bridson PK
Mol Pharmacol; 1991 Sep; 40(3):440-5. PubMed ID: 1654517
[TBL] [Abstract][Full Text] [Related]
9. Spin trapping of radicals other than the *OH radical upon reduction of the anticancer agent tirapazamine by cytochrome P450 reductase.
Shinde SS; Hay MP; Patterson AV; Denny WA; Anderson RF
J Am Chem Soc; 2009 Oct; 131(40):14220-1. PubMed ID: 19772319
[TBL] [Abstract][Full Text] [Related]
10. Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Xia Q; Zhang L; Zhang J; Sheng R; Yang B; He Q; Hu Y
Eur J Med Chem; 2011 Mar; 46(3):919-26. PubMed ID: 21281992
[TBL] [Abstract][Full Text] [Related]
11. Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.
Wardman P; Priyadarsini KI; Dennis MF; Everett SA; Naylor MA; Patel KB; Stratford IJ; Stratford MR; Tracy M
Br J Cancer Suppl; 1996 Jul; 27():S70-4. PubMed ID: 8763850
[TBL] [Abstract][Full Text] [Related]
12. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
Junnotula V; Sarkar U; Sinha S; Gates KS
J Am Chem Soc; 2009 Jan; 131(3):1015-24. PubMed ID: 19117394
[TBL] [Abstract][Full Text] [Related]
13. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
Walton MI; Workman P
J Pharmacol Exp Ther; 1993 May; 265(2):938-47. PubMed ID: 8496834
[TBL] [Abstract][Full Text] [Related]
14. Hypoxia-selective 3-alkyl 1,2,4-benzotriazine 1,4-dioxides: the influence of hydrogen bond donors on extravascular transport and antitumor activity.
Hay MP; Pchalek K; Pruijn FB; Hicks KO; Siim BG; Anderson RF; Shinde SS; Phillips V; Denny WA; Wilson WR
J Med Chem; 2007 Dec; 50(26):6654-64. PubMed ID: 18052317
[TBL] [Abstract][Full Text] [Related]
15. Spin Trapping Hydroxyl and Aryl Radicals of One-Electron Reduced Anticancer Benzotriazine 1,4-Dioxides.
Qi W; Yadav P; Hong CR; Stevenson RJ; Hay MP; Anderson RF
Molecules; 2022 Jan; 27(3):. PubMed ID: 35164077
[TBL] [Abstract][Full Text] [Related]
16. Tirapazamine: laboratory data relevant to clinical activity.
Brown JM; Wang LH
Anticancer Drug Des; 1998 Sep; 13(6):529-39. PubMed ID: 9755717
[TBL] [Abstract][Full Text] [Related]
17. Homologous recombination repair-dependent cytotoxicity of the benzotriazine di-N-oxide CEN-209: comparison with other hypoxia-activated prodrugs.
Hunter FW; Wang J; Patel R; Hsu HL; Hickey AJ; Hay MP; Wilson WR
Biochem Pharmacol; 2012 Mar; 83(5):574-85. PubMed ID: 22182429
[TBL] [Abstract][Full Text] [Related]
18. Putative electron-affinic radiosensitizers and markers of hypoxic tissue: Synthesis and preliminary in vitro biological characterization of C3-amino-substituted benzotriazine dioxides (BTDOs).
Elsaidi HR; Yang XH; Ahmadi F; Weinfeld M; Wiebe LI; Kumar P
Eur J Med Chem; 2019 Mar; 165():216-224. PubMed ID: 30684798
[TBL] [Abstract][Full Text] [Related]
19. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Birincioglu M; Jaruga P; Chowdhury G; Rodriguez H; Dizdaroglu M; Gates KS
J Am Chem Soc; 2003 Sep; 125(38):11607-15. PubMed ID: 13129365
[TBL] [Abstract][Full Text] [Related]
20. Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives.
Jiang F; Weng Q; Sheng R; Xia Q; He Q; Yang B; Hu Y
Arch Pharm (Weinheim); 2007 May; 340(5):258-63. PubMed ID: 17464965
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
