These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

173 related articles for article (PubMed ID: 15946942)

  • 1. The isoprenoid substrate specificity of isoprenylcysteine carboxylmethyltransferase: development of novel inhibitors.
    Anderson JL; Henriksen BS; Gibbs RA; Hrycyna CA
    J Biol Chem; 2005 Aug; 280(33):29454-61. PubMed ID: 15946942
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Evaluation of substrate and inhibitor binding to yeast and human isoprenylcysteine carboxyl methyltransferases (Icmts) using biotinylated benzophenone-containing photoaffinity probes.
    Hahne K; Vervacke JS; Shrestha L; Donelson JL; Gibbs RA; Distefano MD; Hrycyna CA
    Biochem Biophys Res Commun; 2012 Jun; 423(1):98-103. PubMed ID: 22634004
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Analysis of the kinetic mechanism of recombinant human isoprenylcysteine carboxylmethyltransferase (Icmt).
    Baron RA; Casey PJ
    BMC Biochem; 2004 Dec; 5():19. PubMed ID: 15625008
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mutational analysis of the integral membrane methyltransferase isoprenylcysteine carboxyl methyltransferase (ICMT) reveals potential substrate binding sites.
    Diver MM; Long SB
    J Biol Chem; 2014 Sep; 289(38):26007-26020. PubMed ID: 25059662
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Lipid and sulfur substituted prenylcysteine analogs as human Icmt inhibitors.
    Bergman JA; Hahne K; Hrycyna CA; Gibbs RA
    Bioorg Med Chem Lett; 2011 Sep; 21(18):5616-9. PubMed ID: 21782433
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 9 Structure and function of isoprenylcysteine carboxylmethyltransferase (Icmt): A key enzyme in CaaX processing.
    Anderson JL; Hrycyna CA
    Enzymes; 2006; 24():245-72. PubMed ID: 26718043
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Atomic structure of the eukaryotic intramembrane RAS methyltransferase ICMT.
    Diver MM; Pedi L; Koide A; Koide S; Long SB
    Nature; 2018 Jan; 553(7689):526-529. PubMed ID: 29342140
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing the isoprenylcysteine carboxyl methyltransferase (Icmt) binding pocket: sulfonamide modified farnesyl cysteine (SMFC) analogs as Icmt inhibitors.
    Majmudar JD; Hahne K; Hrycyna CA; Gibbs RA
    Bioorg Med Chem Lett; 2011 May; 21(9):2616-20. PubMed ID: 21334890
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of membrane-associated methyltransferases by a cholesterol-based metal chelator.
    Hodges HB; Zhou M; Haldar S; Anderson JL; Thompson DH; Hrycyna CA
    Bioconjug Chem; 2005; 16(3):490-3. PubMed ID: 15898712
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Solid-phase synthesis of Biotin-S-Farnesyl-L-Cysteine, a surrogate substrate for isoprenylcysteine Carboxylmethyltransferase (ICMT).
    Stevenson GI; Yong S; Fechner GA; Neve J; Lock A; Avery VM
    Bioorg Med Chem Lett; 2013 Oct; 23(20):5671-3. PubMed ID: 23988355
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function.
    Svensson AW; Casey PJ; Young SG; Bergo MO
    Methods Enzymol; 2006; 407():144-59. PubMed ID: 16757321
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Role of isoprenylcysteine carboxylmethyltransferase-catalyzed methylation in Rho function and migration.
    Cushman I; Casey PJ
    J Biol Chem; 2009 Oct; 284(41):27964-27973. PubMed ID: 19651782
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of isoprenylcysteine carboxylmethyltransferase sensitizes common chemotherapies in cervical cancer via Ras-dependent pathway.
    Pan Q; Liu R; Banu H; Ma L; Li H
    Biomed Pharmacother; 2018 Mar; 99():169-175. PubMed ID: 29331763
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells.
    Bergo MO; Leung GK; Ambroziak P; Otto JC; Casey PJ; Young SG
    J Biol Chem; 2000 Jun; 275(23):17605-10. PubMed ID: 10747846
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tumor necrosis factor alpha stimulation of Rac1 activity. Role of isoprenylcysteine carboxylmethyltransferase.
    Papaharalambus C; Sajjad W; Syed A; Zhang C; Bergo MO; Alexander RW; Ahmad M
    J Biol Chem; 2005 May; 280(19):18790-6. PubMed ID: 15647276
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amide-substituted farnesylcysteine analogs as inhibitors of human isoprenylcysteine carboxyl methyltransferase.
    Donelson JL; Hodges HB; Macdougall DD; Henriksen BS; Hrycyna CA; Gibbs RA
    Bioorg Med Chem Lett; 2006 Aug; 16(16):4420-3. PubMed ID: 16777414
    [TBL] [Abstract][Full Text] [Related]  

  • 17. A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells.
    Winter-Vann AM; Baron RA; Wong W; dela Cruz J; York JD; Gooden DM; Bergo MO; Young SG; Toone EJ; Casey PJ
    Proc Natl Acad Sci U S A; 2005 Mar; 102(12):4336-41. PubMed ID: 15784746
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of ICMT induces endothelial cell apoptosis through GRP94.
    Lu Q; Harrington EO; Newton J; Jankowich M; Rounds S
    Am J Respir Cell Mol Biol; 2007 Jul; 37(1):20-30. PubMed ID: 17347446
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mechanism of isoprenylcysteine carboxyl methylation from the crystal structure of the integral membrane methyltransferase ICMT.
    Yang J; Kulkarni K; Manolaridis I; Zhang Z; Dodd RB; Mas-Droux C; Barford D
    Mol Cell; 2011 Dec; 44(6):997-1004. PubMed ID: 22195972
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Amide-modified prenylcysteine based Icmt inhibitors: Structure-activity relationships, kinetic analysis and cellular characterization.
    Majmudar JD; Hodges-Loaiza HB; Hahne K; Donelson JL; Song J; Shrestha L; Harrison ML; Hrycyna CA; Gibbs RA
    Bioorg Med Chem; 2012 Jan; 20(1):283-95. PubMed ID: 22142613
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.