151 related articles for article (PubMed ID: 15951446)
1. Direct determination of unbound intrinsic drug clearance in the microsomal stability assay.
Giuliano C; Jairaj M; Zafiu CM; Laufer R
Drug Metab Dispos; 2005 Sep; 33(9):1319-24. PubMed ID: 15951446
[TBL] [Abstract][Full Text] [Related]
2. Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes.
Obach RS
Drug Metab Dispos; 1999 Nov; 27(11):1350-9. PubMed ID: 10534321
[TBL] [Abstract][Full Text] [Related]
3. A unified model for predicting human hepatic, metabolic clearance from in vitro intrinsic clearance data in hepatocytes and microsomes.
Riley RJ; McGinnity DF; Austin RP
Drug Metab Dispos; 2005 Sep; 33(9):1304-11. PubMed ID: 15932954
[TBL] [Abstract][Full Text] [Related]
4. Prediction of human pharmacokinetics--improving microsome-based predictions of hepatic metabolic clearance.
Fagerholm U
J Pharm Pharmacol; 2007 Oct; 59(10):1427-31. PubMed ID: 17910819
[TBL] [Abstract][Full Text] [Related]
5. Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
Obach RS
Drug Metab Dispos; 1997 Dec; 25(12):1359-69. PubMed ID: 9394025
[TBL] [Abstract][Full Text] [Related]
6. Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fu p/fu mic) for refined prediction of phase I mediated metabolic hepatic clearance.
Deshmukh SV; Harsch A
J Pharmacol Toxicol Methods; 2011; 63(1):35-9. PubMed ID: 20433934
[TBL] [Abstract][Full Text] [Related]
7. Prediction of human pharmacokinetics--evaluation of methods for prediction of hepatic metabolic clearance.
Fagerholm U
J Pharm Pharmacol; 2007 Jun; 59(6):803-28. PubMed ID: 17637173
[TBL] [Abstract][Full Text] [Related]
8. Use of intrinsic clearance for prediction of human hepatic clearance.
Chao P; Uss AS; Cheng KC
Expert Opin Drug Metab Toxicol; 2010 Feb; 6(2):189-98. PubMed ID: 20073997
[TBL] [Abstract][Full Text] [Related]
9. Influence of microsomal concentration on apparent intrinsic clearance: implications for scaling in vitro data.
Kalvass JC; Tess DA; Giragossian C; Linhares MC; Maurer TS
Drug Metab Dispos; 2001 Oct; 29(10):1332-6. PubMed ID: 11560877
[TBL] [Abstract][Full Text] [Related]
10. New method for the simultaneous estimation of intrinsic hepatic clearance and protein binding by matrix inhibition.
Uchimura T; Kato M; Tachibana T; Arai S; Nabuchi Y; Saito K; Kinoshita H
Biopharm Drug Dispos; 2008 Jan; 29(1):7-16. PubMed ID: 17941035
[TBL] [Abstract][Full Text] [Related]
11. Evaluation of cryopreserved human hepatocytes as an alternative in vitro system to microsomes for the prediction of metabolic clearance.
Brown HS; Griffin M; Houston JB
Drug Metab Dispos; 2007 Feb; 35(2):293-301. PubMed ID: 17132764
[TBL] [Abstract][Full Text] [Related]
12. Prediction of hepatic microsomal intrinsic clearance and human clearance values for drugs.
Nikolic K; Agababa D
J Mol Graph Model; 2009 Oct; 28(3):245-52. PubMed ID: 19713138
[TBL] [Abstract][Full Text] [Related]
13. The prediction of human clearance from hepatic microsomal metabolism data.
Obach RS
Curr Opin Drug Discov Devel; 2001 Jan; 4(1):36-44. PubMed ID: 11727321
[TBL] [Abstract][Full Text] [Related]
14. A convenient in vitro screening method for predicting in vivo drug metabolic clearance using isolated hepatocytes suspended in serum.
Shibata Y; Takahashi H; Ishii Y
Drug Metab Dispos; 2000 Dec; 28(12):1518-23. PubMed ID: 11095592
[TBL] [Abstract][Full Text] [Related]
15. Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
Stringer RA; Strain-Damerell C; Nicklin P; Houston JB
Drug Metab Dispos; 2009 May; 37(5):1025-34. PubMed ID: 19196847
[TBL] [Abstract][Full Text] [Related]
16. Three-dimensional quantitative structure activity relationship computational approaches for prediction of human in vitro intrinsic clearance.
Ekins S; Obach RS
J Pharmacol Exp Ther; 2000 Nov; 295(2):463-73. PubMed ID: 11046077
[TBL] [Abstract][Full Text] [Related]
17. Intrinsic Clearance Assay Incubational Binding: A Method Comparison.
Chen S; Prieto Garcia L; Bergström F; Nordell P; Grime K
Drug Metab Dispos; 2017 Apr; 45(4):342-345. PubMed ID: 28122786
[TBL] [Abstract][Full Text] [Related]
18. In silico modeling of nonspecific binding to human liver microsomes.
Gao H; Yao L; Mathieu HW; Zhang Y; Maurer TS; Troutman MD; Scott DO; Ruggeri RB; Lin J
Drug Metab Dispos; 2008 Oct; 36(10):2130-5. PubMed ID: 18606744
[TBL] [Abstract][Full Text] [Related]
19. Prediction of human pharmacokinetics from preclinical information: comparative accuracy of quantitative prediction approaches.
Hosea NA; Collard WT; Cole S; Maurer TS; Fang RX; Jones H; Kakar SM; Nakai Y; Smith BJ; Webster R; Beaumont K
J Clin Pharmacol; 2009 May; 49(5):513-33. PubMed ID: 19299532
[TBL] [Abstract][Full Text] [Related]
20. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Di L; Keefer C; Scott DO; Strelevitz TJ; Chang G; Bi YA; Lai Y; Duckworth J; Fenner K; Troutman MD; Obach RS
Eur J Med Chem; 2012 Nov; 57():441-8. PubMed ID: 22840492
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
