BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 1596289)

  • 1. Kinetic characteristics of ICI D1694: a quinazoline antifolate which inhibits thymidylate synthase.
    Ward WH; Kimbell R; Jackman AL
    Biochem Pharmacol; 1992 May; 43(9):2029-31. PubMed ID: 1596289
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL; Taylor GA; Gibson W; Kimbell R; Brown M; Calvert AH; Judson IR; Hughes LR
    Cancer Res; 1991 Oct; 51(20):5579-86. PubMed ID: 1913676
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The measurement of polyglutamate metabolites of the thymidylate synthase inhibitor, ICI D1694, in mouse and human cultured cells.
    Gibson W; Bisset GM; Marsham PR; Kelland LR; Judson IR; Jackman AL
    Biochem Pharmacol; 1993 Feb; 45(4):863-9. PubMed ID: 7680860
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
    Yin MB; Guimaraes MA; Zhang ZG; Arredondo MA; Rustum YM
    Cancer Res; 1992 Nov; 52(21):5900-5. PubMed ID: 1394217
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The thymidylate synthase inhibitor, ICI D1694, overcomes translational detainment of the enzyme.
    Keyomarsi K; Samet J; Molnar G; Pardee AB
    J Biol Chem; 1993 Jul; 268(20):15142-9. PubMed ID: 8325888
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of the reduced-folate carrier and metabolism to intracellular polyglutamates for the activity of ICI D1694.
    Jackman AL; Gibson W; Brown M; Kimbell R; Boyle FT
    Adv Exp Med Biol; 1993; 339():265-76. PubMed ID: 7513935
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
    Rosowsky A; Galivan J; Beardsley GP; Bader H; O'Connor BM; Russello O; Moroson BA; DeYarman MT; Kerwar SS; Freisheim JH
    Cancer Res; 1992 Apr; 52(8):2148-55. PubMed ID: 1313737
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The biochemical pharmacology of the thymidylate synthase inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Jackman AL; Newell DR; Gibson W; Jodrell DI; Taylor GA; Bishop JA; Hughes LR; Calvert AH
    Biochem Pharmacol; 1991 Oct; 42(10):1885-95. PubMed ID: 1741766
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Susceptibility of Plasmodium falciparum to a combination of thymidine and ICI D1694, a quinazoline antifolate directed at thymidylate synthase.
    Rathod PK; Reshmi S
    Antimicrob Agents Chemother; 1994 Mar; 38(3):476-80. PubMed ID: 8203840
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
    Lu K; Yin MB; McGuire JJ; Bonmassar E; Rustum YM
    Biochem Pharmacol; 1995 Jul; 50(3):391-8. PubMed ID: 7646540
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
    Chong LK; Tattersall MH
    Biochem Pharmacol; 1995 Mar; 49(6):819-27. PubMed ID: 7702640
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression.
    Pressacco J; Mitrovski B; Erlichman C; Hedley DW
    Cancer Res; 1995 Apr; 55(7):1505-8. PubMed ID: 7882359
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW; Hardcastle A; Raynaud F; Jackman AL
    Biochem Pharmacol; 1996 May; 51(10):1293-301. PubMed ID: 8787544
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.
    Bisset GM; Pawelczak K; Jackman AL; Calvert AH; Hughes LR
    J Med Chem; 1992 Mar; 35(5):859-66. PubMed ID: 1372358
    [TBL] [Abstract][Full Text] [Related]  

  • 15. ICI D1694, an inhibitor of thymidylate synthase for clinical study.
    Jackman AL; Jodrell DI; Gibson W; Stephens TC
    Adv Exp Med Biol; 1991; 309A():19-23. PubMed ID: 1789205
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates.
    Jackman AL; Marsham PR; Moran RG; Kimbell R; O'Connor BM; Hughes LR; Calvert AH
    Adv Enzyme Regul; 1991; 31():13-27. PubMed ID: 1877386
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Combination studies with 3'-azido-3'-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects.
    Pressacco J; Erlichman C
    Biochem Pharmacol; 1993 Dec; 46(11):1989-97. PubMed ID: 8267649
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats.
    Jodrell DI; Newell DR; Gibson W; Hughes LR; Calvert AH
    Cancer Chemother Pharmacol; 1991; 28(5):331-8. PubMed ID: 1914075
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
    Li WW; Tong WP; Bertino JR
    Clin Cancer Res; 1995 Jun; 1(6):631-6. PubMed ID: 9816025
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cellular heterogeneity in DNA damage and growth inhibition induced by ICI D1694, thymidylate synthase inhibitor, using single cell assays.
    Schöber C; Gibbs JF; Yin MB; Slocum HK; Rustum YM
    Biochem Pharmacol; 1994 Aug; 48(5):997-1002. PubMed ID: 8093112
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.