207 related articles for article (PubMed ID: 15963514)
1. 2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.
Tait A; Luppi A; Avallone R; Baraldi M
Farmaco; 2005 Aug; 60(8):653-63. PubMed ID: 15963514
[TBL] [Abstract][Full Text] [Related]
2. Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors.
Tait A; Luppi A; Hatzelmann A; Fossa P; Mosti L
Bioorg Med Chem; 2005 Feb; 13(4):1393-402. PubMed ID: 15670947
[TBL] [Abstract][Full Text] [Related]
3. Benzyl derivatives of 2,1,3-benzo- and benzothieno[3,2-a]thiadiazine 2,2-dioxides: first phosphodiesterase 7 inhibitors.
Martínez A; Castro A; Gil C; Miralpeix M; Segarra V; Doménech T; Beleta J; Palacios JM; Ryder H; Miró X; Bonet C; Casacuberta JM; Azorín F; Piña B; Puigdoménech P
J Med Chem; 2000 Feb; 43(4):683-9. PubMed ID: 10691694
[TBL] [Abstract][Full Text] [Related]
4. Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure-activity relationships.
Ko WC; Shih CM; Lai YH; Chen JH; Huang HL
Biochem Pharmacol; 2004 Nov; 68(10):2087-94. PubMed ID: 15476679
[TBL] [Abstract][Full Text] [Related]
5. Synthesis and structure-activity relationships of cis-tetrahydrophthalazinone/pyridazinone hybrids: a novel series of potent dual PDE3/PDE4 inhibitory agents.
Van der Mey M; Bommelé KM; Boss H; Hatzelmann A; Van Slingerland M; Sterk GJ; Timmerman H
J Med Chem; 2003 May; 46(10):2008-16. PubMed ID: 12723963
[TBL] [Abstract][Full Text] [Related]
6. First dual M3 antagonists-PDE4 inhibitors: synthesis and SAR of 4,6-diaminopyrimidine derivatives.
Provins L; Christophe B; Danhaive P; Dulieu J; Durieu V; Gillard M; Lebon F; Lengelé S; Quéré L; van Keulen B
Bioorg Med Chem Lett; 2006 Apr; 16(7):1834-9. PubMed ID: 16439121
[TBL] [Abstract][Full Text] [Related]
7. New orally active PDE4 inhibitors with therapeutic potential.
Ochiai H; Ishida A; Ohtani T; Kusumi K; Kishikawa K; Yamamoto S; Takeda H; Obata T; Nakai H; Toda M
Bioorg Med Chem; 2004 Aug; 12(15):4089-100. PubMed ID: 15246087
[TBL] [Abstract][Full Text] [Related]
8. Discovery of thiadiazoles as a novel structural class of potent and selective PDE7 inhibitors. Part 1: design, synthesis and structure-activity relationship studies.
Vergne F; Bernardelli P; Lorthiois E; Pham N; Proust E; Oliveira C; Mafroud AK; Royer F; Wrigglesworth R; Schellhaas J; Barvian M; Moreau F; Idrissi M; Tertre A; Bertin B; Coupe M; Berna P; Soulard P
Bioorg Med Chem Lett; 2004 Sep; 14(18):4607-13. PubMed ID: 15324874
[TBL] [Abstract][Full Text] [Related]
9. Enaminones 9. Further studies on the anticonvulsant activity and potential type IV phosphodiesterase inhibitory activity of substituted vinylic benzamides.
Anderson AJ; Nicholson JM; Bakare O; Butcher RJ; Wilson TL; Scott KR
Bioorg Med Chem; 2006 Feb; 14(4):997-1006. PubMed ID: 16219468
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of novel imidazo[1,2-a]quinoxalines as PDE4 inhibitors.
Deleuze-Masquéfa C; Gerebtzoff G; Subra G; Fabreguettes JR; Ovens A; Carraz M; Strub MP; Bompart J; George P; Bonnet PA
Bioorg Med Chem; 2004 Mar; 12(5):1129-39. PubMed ID: 14980625
[TBL] [Abstract][Full Text] [Related]
11. Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1.
Lorthiois E; Bernardelli P; Vergne F; Oliveira C; Mafroud AK; Proust E; Heuze L; Moreau F; Idrissi M; Tertre A; Bertin B; Coupe M; Wrigglesworth R; Descours A; Soulard P; Berna P
Bioorg Med Chem Lett; 2004 Sep; 14(18):4623-6. PubMed ID: 15324876
[TBL] [Abstract][Full Text] [Related]
12. Identification of purine inhibitors of phosphodiesterase 7 (PDE7).
Pitts WJ; Vaccaro W; Huynh T; Leftheris K; Roberge JY; Barbosa J; Guo J; Brown B; Watson A; Donaldson K; Starling GC; Kiener PA; Poss MA; Dodd JH; Barrish JC
Bioorg Med Chem Lett; 2004 Jun; 14(11):2955-8. PubMed ID: 15125967
[TBL] [Abstract][Full Text] [Related]
13. 8-Substituted analogues of 3-(3-cyclopentyloxy-4-methoxy-benzyl)-8-isopropyl-adenine: highly potent and selective PDE4 inhibitors.
Whitehead JW; Lee GP; Gharagozloo P; Hofer P; Gehrig A; Wintergerst P; Smyth D; McCoull W; Hachicha M; Patel A; Kyle DJ
J Med Chem; 2005 Feb; 48(4):1237-43. PubMed ID: 15715490
[TBL] [Abstract][Full Text] [Related]
14. Phthalazine PDE4 inhibitors. Part 2: the synthesis and biological evaluation of 6-methoxy-1,4-disubstituted derivatives.
Napoletano M; Norcini G; Pellacini F; Marchini F; Morazzoni G; Ferlenga P; Pradella L
Bioorg Med Chem Lett; 2001 Jan; 11(1):33-7. PubMed ID: 11140727
[TBL] [Abstract][Full Text] [Related]
15. Novel, potent, and selective phosphodiesterase-4 inhibitors as antiasthmatic agents: synthesis and biological activities of a series of 1-pyridylnaphthalene derivatives.
Ukita T; Sugahara M; Terakawa Y; Kuroda T; Wada K; Nakata A; Ohmachi Y; Kikkawa H; Ikezawa K; Naito K
J Med Chem; 1999 Mar; 42(6):1088-99. PubMed ID: 10090791
[TBL] [Abstract][Full Text] [Related]
16. Orally active PDE4 inhibitors with therapeutic potential.
Ochiai H; Ohtani T; Ishida A; Kishikawa K; Obata T; Nakai H; Toda M
Bioorg Med Chem Lett; 2004 Mar; 14(5):1323-7. PubMed ID: 14980691
[TBL] [Abstract][Full Text] [Related]
17. Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.
Barnes MJ; Cooper N; Davenport RJ; Dyke HJ; Galleway FP; Galvin FC; Gowers L; Haughan AF; Lowe C; Meissner JW; Montana JG; Morgan T; Picken CL; Watson RJ
Bioorg Med Chem Lett; 2001 Apr; 11(8):1081-3. PubMed ID: 11327595
[TBL] [Abstract][Full Text] [Related]
18. Dual M3 antagonists-PDE4 inhibitors. Part 2: Synthesis and SAR of 3-substituted azetidinyl derivatives.
Provins L; Christophe B; Danhaive P; Dulieu J; Gillard M; Quéré L; Stebbins K
Bioorg Med Chem Lett; 2007 Jun; 17(11):3077-80. PubMed ID: 17398090
[TBL] [Abstract][Full Text] [Related]
19. 9-Benzyladenines: potent and selective cAMP phosphodiesterase inhibitors.
Bourguignon JJ; Désaubry L; Raboisson P; Wermuth CG; Lugnier C
J Med Chem; 1997 Jun; 40(12):1768-70. PubMed ID: 9191951
[No Abstract] [Full Text] [Related]
20. Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
Kempson J; Pitts WJ; Barbosa J; Guo J; Omotoso O; Watson A; Stebbins K; Starling GC; Dodd JH; Barrish JC; Felix R; Fischer K
Bioorg Med Chem Lett; 2005 Apr; 15(7):1829-33. PubMed ID: 15780616
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
