These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

92 related articles for article (PubMed ID: 15968387)

  • 21. Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo.
    Tsiang M; Paborsky LR; Li WX; Jain AK; Mao CT; Dunn KE; Lee DW; Matsumura SY; Matteucci MD; Coutré SE; Leung LL; Gibbs CS
    Biochemistry; 1996 Dec; 35(51):16449-57. PubMed ID: 8987977
    [TBL] [Abstract][Full Text] [Related]  

  • 22. A natural prothrombin mutant reveals an unexpected influence of A-chain structure on the activity of human alpha-thrombin.
    De Cristofaro R; Akhavan S; Altomare C; Carotti A; Peyvandi F; Mannucci PM
    J Biol Chem; 2004 Mar; 279(13):13035-43. PubMed ID: 14722067
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin.
    Koike H; Okuda D; Morita T
    J Biol Chem; 2003 Apr; 278(17):15015-22. PubMed ID: 12588872
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Heparin-activated antithrombin interacts with the autolysis loop of target coagulation proteases.
    Yang L; Manithody C; Rezaie AR
    Blood; 2004 Sep; 104(6):1753-9. PubMed ID: 15178583
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Selective loss of fibrinogen clotting in a loop-less thrombin.
    Dang QD; Sabetta M; Di Cera E
    J Biol Chem; 1997 Aug; 272(32):19649-51. PubMed ID: 9242618
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The functional significance of the autolysis loop in protein C and activated protein C.
    Yang L; Manithody C; Rezaie AR
    Thromb Haemost; 2005 Jul; 94(1):60-8. PubMed ID: 16113785
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding site for the serpin and allosterically modulating the activity of thrombin.
    Yang L; Manithody C; Walston TD; Cooper ST; Rezaie AR
    J Biol Chem; 2003 Sep; 278(39):37465-70. PubMed ID: 12878585
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Mutagenesis studies toward understanding the mechanism of differential reactivity of factor Xa with the native and heparin-activated antithrombin.
    Rezaie AR; Yang L; Manithody C
    Biochemistry; 2004 Mar; 43(10):2898-905. PubMed ID: 15005625
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Energetics of thrombin-thrombomodulin interaction.
    Vindigni A; White CE; Komives EA; Di Cera E
    Biochemistry; 1997 Jun; 36(22):6674-81. PubMed ID: 9184147
    [TBL] [Abstract][Full Text] [Related]  

  • 30. The effects of exosite occupancy on the substrate specificity of thrombin.
    Ng NM; Quinsey NS; Matthews AY; Kaiserman D; Wijeyewickrema LC; Bird PI; Thompson PE; Pike RN
    Arch Biochem Biophys; 2009 Sep; 489(1-2):48-54. PubMed ID: 19638274
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop.
    Dekker RJ; Eichinger A; Stoop AA; Bode W; Pannekoek H; Horrevoets AJ
    J Mol Biol; 1999 Oct; 293(3):613-27. PubMed ID: 10543954
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Inhibitory mechanism of serpins. Identification of steps involving the active-site serine residue of the protease.
    Stone SR; Le Bonniec BF
    J Mol Biol; 1997 Jan; 265(3):344-62. PubMed ID: 9018048
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Rational engineering of activity and specificity in a serine protease.
    Dang QD; Guinto ER; di Cera E
    Nat Biotechnol; 1997 Feb; 15(2):146-9. PubMed ID: 9035139
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Contribution of basic residues of the 70-80-loop to heparin binding and anticoagulant function of activated protein C.
    Yang L; Manithody C; Rezaie AR
    Biochemistry; 2002 May; 41(19):6149-57. PubMed ID: 11994010
    [TBL] [Abstract][Full Text] [Related]  

  • 35. The Importance of Exosite Interactions for Substrate Cleavage by Human Thrombin.
    Chahal G; Thorpe M; Hellman L
    PLoS One; 2015; 10(6):e0129511. PubMed ID: 26110612
    [TBL] [Abstract][Full Text] [Related]  

  • 36. The thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I.
    Pineda AO; Cantwell AM; Bush LA; Rose T; Di Cera E
    J Biol Chem; 2002 Aug; 277(35):32015-9. PubMed ID: 12068020
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Thrombin mutants with altered enzymatic activity have an impaired mitogenic effect on mouse fibroblasts and are inefficient modulators of stellation of rat cortical astrocytes.
    Arcone R; Pagliuca MG; Chinali A; Grimaldi M; Schettini G; Gast A; Pietropaolo C
    Biochim Biophys Acta; 1999 Aug; 1451(1):173-86. PubMed ID: 10446399
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Involvement of thrombin anion-binding exosites 1 and 2 in the activation of factor V and factor VIII.
    Esmon CT; Lollar P
    J Biol Chem; 1996 Jun; 271(23):13882-7. PubMed ID: 8662922
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin.
    Peacock RB; Davis JR; Markwick PRL; Komives EA
    Biochemistry; 2018 May; 57(18):2694-2703. PubMed ID: 29634247
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket.
    Pineda AO; Chen ZW; Caccia S; Cantwell AM; Savvides SN; Waksman G; Mathews FS; Di Cera E
    J Biol Chem; 2004 Sep; 279(38):39824-8. PubMed ID: 15252033
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 5.