BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

441 related articles for article (PubMed ID: 15970689)

  • 1. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.
    Lu X; Nguyen TA; Donehower LA
    Cell Cycle; 2005 Aug; 4(8):1060-4. PubMed ID: 15970689
    [TBL] [Abstract][Full Text] [Related]  

  • 2. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints.
    Lu X; Nannenga B; Donehower LA
    Genes Dev; 2005 May; 19(10):1162-74. PubMed ID: 15870257
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wip1 phosphatase.
    Yoda A; Toyoshima K; Watanabe Y; Onishi N; Hazaka Y; Tsukuda Y; Tsukada J; Kondo T; Tanaka Y; Minami Y
    J Biol Chem; 2008 Jul; 283(27):18969-79. PubMed ID: 18482988
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases.
    Yamaguchi H; Durell SR; Chatterjee DK; Anderson CW; Appella E
    Biochemistry; 2007 Nov; 46(44):12594-603. PubMed ID: 17939684
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Wip1 phosphatase modulates ATM-dependent signaling pathways.
    Shreeram S; Demidov ON; Hee WK; Yamaguchi H; Onishi N; Kek C; Timofeev ON; Dudgeon C; Fornace AJ; Anderson CW; Minami Y; Appella E; Bulavin DV
    Mol Cell; 2006 Sep; 23(5):757-64. PubMed ID: 16949371
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.
    Nannenga B; Lu X; Dumble M; Van Maanen M; Nguyen TA; Sutton R; Kumar TR; Donehower LA
    Mol Carcinog; 2006 Aug; 45(8):594-604. PubMed ID: 16652371
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
    Shreeram S; Hee WK; Demidov ON; Kek C; Yamaguchi H; Fornace AJ; Anderson CW; Appella E; Bulavin DV
    J Exp Med; 2006 Dec; 203(13):2793-9. PubMed ID: 17158963
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
    Yagi H; Chuman Y; Kozakai Y; Imagawa T; Takahashi Y; Yoshimura F; Tanino K; Sakaguchi K
    Bioorg Med Chem Lett; 2012 Jan; 22(1):729-32. PubMed ID: 22115592
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop.
    Lu X; Ma O; Nguyen TA; Jones SN; Oren M; Donehower LA
    Cancer Cell; 2007 Oct; 12(4):342-54. PubMed ID: 17936559
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.
    Moon SH; Nguyen TA; Darlington Y; Lu X; Donehower LA
    Cell Cycle; 2010 Jun; 9(11):2092-6. PubMed ID: 20495376
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.
    Lu X; Nguyen TA; Moon SH; Darlington Y; Sommer M; Donehower LA
    Cancer Metastasis Rev; 2008 Jun; 27(2):123-35. PubMed ID: 18265945
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.
    Moon SH; Lin L; Zhang X; Nguyen TA; Darlington Y; Waldman AS; Lu X; Donehower LA
    J Biol Chem; 2010 Apr; 285(17):12935-47. PubMed ID: 20118229
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins.
    Lu X; Nguyen TA; Appella E; Donehower LA
    Cell Cycle; 2004 Nov; 3(11):1363-6. PubMed ID: 15539943
    [TBL] [Abstract][Full Text] [Related]  

  • 14. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage.
    Reinhardt HC; Aslanian AS; Lees JA; Yaffe MB
    Cancer Cell; 2007 Feb; 11(2):175-89. PubMed ID: 17292828
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.
    Carlessi L; Buscemi G; Fontanella E; Delia D
    Biochim Biophys Acta; 2010 Oct; 1803(10):1213-23. PubMed ID: 20599567
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
    Khoronenkova SV; Dianova II; Ternette N; Kessler BM; Parsons JL; Dianov GL
    Mol Cell; 2012 Mar; 45(6):801-13. PubMed ID: 22361354
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
    Bulavin DV; Demidov ON; Saito S; Kauraniemi P; Phillips C; Amundson SA; Ambrosino C; Sauter G; Nebreda AR; Anderson CW; Kallioniemi A; Fornace AJ; Appella E
    Nat Genet; 2002 Jun; 31(2):210-5. PubMed ID: 12021785
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A positive role for c-Abl in Atm and Atr activation in DNA damage response.
    Wang X; Zeng L; Wang J; Chau JF; Lai KP; Jia D; Poonepalli A; Hande MP; Liu H; He G; He L; Li B
    Cell Death Differ; 2011 Jan; 18(1):5-15. PubMed ID: 20798688
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.
    Lee HJ; Hwang HI; Jang YJ
    Cell Cycle; 2010 Jun; 9(12):2389-98. PubMed ID: 20581453
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
    Nguyen TA; Slattery SD; Moon SH; Darlington YF; Lu X; Donehower LA
    DNA Repair (Amst); 2010 Jul; 9(7):813-23. PubMed ID: 20451471
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.