259 related articles for article (PubMed ID: 15985365)
1. The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11beta-hydroxylase) inhibitors.
Müller-Vieira U; Angotti M; Hartmann RW
J Steroid Biochem Mol Biol; 2005 Aug; 96(3-4):259-70. PubMed ID: 15985365
[TBL] [Abstract][Full Text] [Related]
2. A steady state system for in vitro evaluation of steroidogenic pathway dynamics: Application for CYP11B1, CYP11B2 and CYP17 inhibitors.
Mangelis A; Jühlen R; Dieterich P; Peitzsch M; Lenders JWM; Hahner S; Schirbel A; Eisenhofer G
J Steroid Biochem Mol Biol; 2019 Apr; 188():38-47. PubMed ID: 30529282
[TBL] [Abstract][Full Text] [Related]
3. Identification of the fungicide epoxiconazole by virtual screening and biological assessment as inhibitor of human 11β-hydroxylase and aldosterone synthase.
Akram M; Patt M; Kaserer T; Temml V; Waratchareeyakul W; Kratschmar DV; Haupenthal J; Hartmann RW; Odermatt A; Schuster D
J Steroid Biochem Mol Biol; 2019 Sep; 192():105358. PubMed ID: 30965118
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.
Ulmschneider S; Müller-Vieira U; Mitrenga M; Hartmann RW; Oberwinkler-Marchais S; Klein CD; Bureik M; Bernhardt R; Antes I; Lengauer T
J Med Chem; 2005 Mar; 48(6):1796-805. PubMed ID: 15771425
[TBL] [Abstract][Full Text] [Related]
5. Heteroatom insertion into 3,4-dihydro-1H-quinolin-2-ones leads to potent and selective inhibitors of human and rat aldosterone synthase.
Grombein CM; Hu Q; Rau S; Zimmer C; Hartmann RW
Eur J Med Chem; 2015 Jan; 90():788-96. PubMed ID: 25528333
[TBL] [Abstract][Full Text] [Related]
6. Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.
Cerny MA; Csengery A; Schmenk J; Frederick K
J Steroid Biochem Mol Biol; 2015 Nov; 154():197-205. PubMed ID: 26303746
[TBL] [Abstract][Full Text] [Related]
7. Development of test systems for the discovery of selective human aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) inhibitors. Discovery of a new lead compound for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Bureik M; Hübel K; Dragan CA; Scher J; Becker H; Lenz N; Bernhardt R
Mol Cell Endocrinol; 2004 Mar; 217(1-2):249-54. PubMed ID: 15134825
[TBL] [Abstract][Full Text] [Related]
8. Impact of Aldosterone Synthase Inhibitor FAD286 on Steroid Hormone Profile in Human Adrenocortical Cells.
Brunssen C; Hofmann A; Peitzsch M; Frenzel A; Ziegler CG; Brown NF; Weldon SM; Eisenhofer G; Willenberg HS; Bornstein SR; Morawietz H
Horm Metab Res; 2017 Sep; 49(9):701-706. PubMed ID: 28759940
[TBL] [Abstract][Full Text] [Related]
9. N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2).
Zimmer C; Hafner M; Zender M; Ammann D; Hartmann RW; Vock CA
Bioorg Med Chem Lett; 2011 Jan; 21(1):186-90. PubMed ID: 21129965
[TBL] [Abstract][Full Text] [Related]
10. The development of a whole-cell based medium throughput screening system for the discovery of human aldosterone synthase (CYP11B2) inhibitors: old drugs disclose new applications for the therapy of congestive heart failure, myocardial fibrosis and hypertension.
Hakki T; Hübel K; Waldmann H; Bernhardt R
J Steroid Biochem Mol Biol; 2011 May; 125(1-2):120-8. PubMed ID: 21193036
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Ulmschneider S; Müller-Vieira U; Klein CD; Antes I; Lengauer T; Hartmann RW
J Med Chem; 2005 Mar; 48(5):1563-75. PubMed ID: 15743198
[TBL] [Abstract][Full Text] [Related]
12. Novel pyridyl- or isoquinolinyl-substituted indolines and indoles as potent and selective aldosterone synthase inhibitors.
Yin L; Hu Q; Emmerich J; Lo MM; Metzger E; Ali A; Hartmann RW
J Med Chem; 2014 Jun; 57(12):5179-89. PubMed ID: 24899257
[TBL] [Abstract][Full Text] [Related]
13. Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.
LaSala D; Shibanaka Y; Jeng AY
Anal Biochem; 2009 Nov; 394(1):56-61. PubMed ID: 19622340
[TBL] [Abstract][Full Text] [Related]
14. Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.
Ehmer PB; Bureik M; Bernhardt R; Müller U; Hartmann RW
J Steroid Biochem Mol Biol; 2002 Jun; 81(2):173-9. PubMed ID: 12137808
[TBL] [Abstract][Full Text] [Related]
15. Rhesus monkey model for concurrent analyses of in vivo selectivity, pharmacokinetics and pharmacodynamics of aldosterone synthase inhibitors.
Cai TQ; Stribling S; Tong X; Xu L; Wisniewski T; Fontenot JA; Struthers M; Akinsanya KO
J Pharmacol Toxicol Methods; 2015; 71():137-46. PubMed ID: 25304940
[TBL] [Abstract][Full Text] [Related]
16. Modulation of cytochromes P450 with xanthone-based molecules: from aromatase to aldosterone synthase and steroid 11β-hydroxylase inhibition.
Gobbi S; Hu Q; Negri M; Zimmer C; Belluti F; Rampa A; Hartmann RW; Bisi A
J Med Chem; 2013 Feb; 56(4):1723-9. PubMed ID: 23363058
[TBL] [Abstract][Full Text] [Related]
17. The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.
Adams CM; Hu CW; Jeng AY; Karki R; Ksander G; Lasala D; Leung-Chu J; Liang G; Liu Q; Meredith E; Rao C; Rigel DF; Shi J; Smith S; Springer C; Zhang C
Bioorg Med Chem Lett; 2010 Aug; 20(15):4324-7. PubMed ID: 20615692
[TBL] [Abstract][Full Text] [Related]
18. Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
Voets M; Antes I; Scherer C; Müller-Vieira U; Biemel K; Barassin C; Marchais-Oberwinkler S; Hartmann RW
J Med Chem; 2005 Oct; 48(21):6632-42. PubMed ID: 16220979
[TBL] [Abstract][Full Text] [Related]
19. Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression.
Liakos P; Lenz D; Bernhardt R; Feige JJ; Defaye G
J Endocrinol; 2003 Jan; 176(1):69-82. PubMed ID: 12525251
[TBL] [Abstract][Full Text] [Related]
20. Adrenocortical zonation in humans under normal and pathological conditions.
Nishimoto K; Nakagawa K; Li D; Kosaka T; Oya M; Mikami S; Shibata H; Itoh H; Mitani F; Yamazaki T; Ogishima T; Suematsu M; Mukai K
J Clin Endocrinol Metab; 2010 May; 95(5):2296-305. PubMed ID: 20200334
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
